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Efficacy of Supportive Care for Radiodermatitis in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial

Self-care demonstrated efficacy in preventing severe acute radiation dermatitis among patients with head and neck squamous cell carcinoma undergoing chemoradiotherapy (CRT). This prospective trial aimed to confirm the feasibility and safety of transcutaneous electrical sensory stimulation while exam...

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Autores principales: Katsuta, Tsuyoshi, Nishibuchi, Ikuno, Nomura, Megumi, Kondo, Miho, Hamamoto, Takao, Ueda, Tsutomu, Batsuuri, Bilegsaikhan, Sadatoki, Takashi, Imano, Nobuki, Hirokawa, Junichi, Murakami, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533091/
https://www.ncbi.nlm.nih.gov/pubmed/37763155
http://dx.doi.org/10.3390/jpm13091387
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author Katsuta, Tsuyoshi
Nishibuchi, Ikuno
Nomura, Megumi
Kondo, Miho
Hamamoto, Takao
Ueda, Tsutomu
Batsuuri, Bilegsaikhan
Sadatoki, Takashi
Imano, Nobuki
Hirokawa, Junichi
Murakami, Yuji
author_facet Katsuta, Tsuyoshi
Nishibuchi, Ikuno
Nomura, Megumi
Kondo, Miho
Hamamoto, Takao
Ueda, Tsutomu
Batsuuri, Bilegsaikhan
Sadatoki, Takashi
Imano, Nobuki
Hirokawa, Junichi
Murakami, Yuji
author_sort Katsuta, Tsuyoshi
collection PubMed
description Self-care demonstrated efficacy in preventing severe acute radiation dermatitis among patients with head and neck squamous cell carcinoma undergoing chemoradiotherapy (CRT). This prospective trial aimed to confirm the feasibility and safety of transcutaneous electrical sensory stimulation while examining the relationship between changes in self-care behavior through supportive care interventions and the severity of acute radiation dermatitis during CRT. Patients underwent assessments for dermatitis grading (Grades 1 to ≥3) and were interviewed regarding self-care practices. The self-care questionnaires comprised six items, and a point was deducted for each task that the patient could not perform independently. Statistical analysis was performed to determine the association between G3 radiation dermatitis and the lowest self-care behavior scores. Of the 10 patients enrolled, three experienced G3 dermatitis. During CRT, six patients maintained their initial scores and did not develop ≥G3 dermatitis. Meanwhile, three of four patients with decreased scores exhibited ≥G3 dermatitis. The group with ≥G3 dermatitis had significantly lower scores than those with ≤G2 dermatitis, suggesting that the inability of patients to perform self-care routinely may lead to severe acute radiation dermatitis. Further prospective studies are needed to confirm the potential of self-care interventions in preventing severe dermatitis.
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spelling pubmed-105330912023-09-28 Efficacy of Supportive Care for Radiodermatitis in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial Katsuta, Tsuyoshi Nishibuchi, Ikuno Nomura, Megumi Kondo, Miho Hamamoto, Takao Ueda, Tsutomu Batsuuri, Bilegsaikhan Sadatoki, Takashi Imano, Nobuki Hirokawa, Junichi Murakami, Yuji J Pers Med Article Self-care demonstrated efficacy in preventing severe acute radiation dermatitis among patients with head and neck squamous cell carcinoma undergoing chemoradiotherapy (CRT). This prospective trial aimed to confirm the feasibility and safety of transcutaneous electrical sensory stimulation while examining the relationship between changes in self-care behavior through supportive care interventions and the severity of acute radiation dermatitis during CRT. Patients underwent assessments for dermatitis grading (Grades 1 to ≥3) and were interviewed regarding self-care practices. The self-care questionnaires comprised six items, and a point was deducted for each task that the patient could not perform independently. Statistical analysis was performed to determine the association between G3 radiation dermatitis and the lowest self-care behavior scores. Of the 10 patients enrolled, three experienced G3 dermatitis. During CRT, six patients maintained their initial scores and did not develop ≥G3 dermatitis. Meanwhile, three of four patients with decreased scores exhibited ≥G3 dermatitis. The group with ≥G3 dermatitis had significantly lower scores than those with ≤G2 dermatitis, suggesting that the inability of patients to perform self-care routinely may lead to severe acute radiation dermatitis. Further prospective studies are needed to confirm the potential of self-care interventions in preventing severe dermatitis. MDPI 2023-09-16 /pmc/articles/PMC10533091/ /pubmed/37763155 http://dx.doi.org/10.3390/jpm13091387 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Katsuta, Tsuyoshi
Nishibuchi, Ikuno
Nomura, Megumi
Kondo, Miho
Hamamoto, Takao
Ueda, Tsutomu
Batsuuri, Bilegsaikhan
Sadatoki, Takashi
Imano, Nobuki
Hirokawa, Junichi
Murakami, Yuji
Efficacy of Supportive Care for Radiodermatitis in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial
title Efficacy of Supportive Care for Radiodermatitis in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial
title_full Efficacy of Supportive Care for Radiodermatitis in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial
title_fullStr Efficacy of Supportive Care for Radiodermatitis in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial
title_full_unstemmed Efficacy of Supportive Care for Radiodermatitis in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial
title_short Efficacy of Supportive Care for Radiodermatitis in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial
title_sort efficacy of supportive care for radiodermatitis in patients with head and neck cancer: supplementary analysis of an exploratory phase ii trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533091/
https://www.ncbi.nlm.nih.gov/pubmed/37763155
http://dx.doi.org/10.3390/jpm13091387
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