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Metabolic Syndrome and Atrial Fibrillation: Different Entities or Combined Disorders

Obesity, hypertension, insulin resistance, and dyslipidemia are all clusters of an entity called “Metabolic Syndrome”. The global trends of this syndrome’s incidence/prevalence continue to increase reciprocally, converting it into a massive epidemic problem in the medical community. Observing the ri...

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Autores principales: Zakynthinos, George E., Tsolaki, Vasiliki, Oikonomou, Evangelos, Vavouranakis, Manolis, Siasos, Gerasimos, Zakynthinos, Epaminondas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533132/
https://www.ncbi.nlm.nih.gov/pubmed/37763092
http://dx.doi.org/10.3390/jpm13091323
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author Zakynthinos, George E.
Tsolaki, Vasiliki
Oikonomou, Evangelos
Vavouranakis, Manolis
Siasos, Gerasimos
Zakynthinos, Epaminondas
author_facet Zakynthinos, George E.
Tsolaki, Vasiliki
Oikonomou, Evangelos
Vavouranakis, Manolis
Siasos, Gerasimos
Zakynthinos, Epaminondas
author_sort Zakynthinos, George E.
collection PubMed
description Obesity, hypertension, insulin resistance, and dyslipidemia are all clusters of an entity called “Metabolic Syndrome”. The global trends of this syndrome’s incidence/prevalence continue to increase reciprocally, converting it into a massive epidemic problem in the medical community. Observing the risk factors of atrial fibrillation, a medical condition that is also converted to a scourge, almost all parts of the metabolic syndrome are encountered. In addition, several studies demonstrated a robust correlation between metabolic syndrome and the occurrence of atrial fibrillation. For atrial fibrillation to develop, a combination of the appropriate substrate and a trigger point is necessary. The metabolic syndrome affects the left atrium in a multifactorial way, leading to atrial remodeling, thus providing both the substrate and provoking the trigger needed, which possibly plays a substantial role in the progression of atrial fibrillation. Due to the remodeling, treatment of atrial fibrillation may culminate in pernicious sequelae, such as repeated catheter ablation procedures. A holistic approach of the patient, with simultaneous treatment of both entities, is suggested in order to ensure better outcomes for the patients.
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spelling pubmed-105331322023-09-28 Metabolic Syndrome and Atrial Fibrillation: Different Entities or Combined Disorders Zakynthinos, George E. Tsolaki, Vasiliki Oikonomou, Evangelos Vavouranakis, Manolis Siasos, Gerasimos Zakynthinos, Epaminondas J Pers Med Review Obesity, hypertension, insulin resistance, and dyslipidemia are all clusters of an entity called “Metabolic Syndrome”. The global trends of this syndrome’s incidence/prevalence continue to increase reciprocally, converting it into a massive epidemic problem in the medical community. Observing the risk factors of atrial fibrillation, a medical condition that is also converted to a scourge, almost all parts of the metabolic syndrome are encountered. In addition, several studies demonstrated a robust correlation between metabolic syndrome and the occurrence of atrial fibrillation. For atrial fibrillation to develop, a combination of the appropriate substrate and a trigger point is necessary. The metabolic syndrome affects the left atrium in a multifactorial way, leading to atrial remodeling, thus providing both the substrate and provoking the trigger needed, which possibly plays a substantial role in the progression of atrial fibrillation. Due to the remodeling, treatment of atrial fibrillation may culminate in pernicious sequelae, such as repeated catheter ablation procedures. A holistic approach of the patient, with simultaneous treatment of both entities, is suggested in order to ensure better outcomes for the patients. MDPI 2023-08-28 /pmc/articles/PMC10533132/ /pubmed/37763092 http://dx.doi.org/10.3390/jpm13091323 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zakynthinos, George E.
Tsolaki, Vasiliki
Oikonomou, Evangelos
Vavouranakis, Manolis
Siasos, Gerasimos
Zakynthinos, Epaminondas
Metabolic Syndrome and Atrial Fibrillation: Different Entities or Combined Disorders
title Metabolic Syndrome and Atrial Fibrillation: Different Entities or Combined Disorders
title_full Metabolic Syndrome and Atrial Fibrillation: Different Entities or Combined Disorders
title_fullStr Metabolic Syndrome and Atrial Fibrillation: Different Entities or Combined Disorders
title_full_unstemmed Metabolic Syndrome and Atrial Fibrillation: Different Entities or Combined Disorders
title_short Metabolic Syndrome and Atrial Fibrillation: Different Entities or Combined Disorders
title_sort metabolic syndrome and atrial fibrillation: different entities or combined disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533132/
https://www.ncbi.nlm.nih.gov/pubmed/37763092
http://dx.doi.org/10.3390/jpm13091323
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