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AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study

Background: Hyperglycemia is a common symptom of numerous conditions, most notably diabetes mellitus and Cushing’s syndrome, and the liver plays a pivotal role in the regulation of glucose metabolism. The AST–platelet ratio index (AST APRI score) and ALT–platelet ratio index (ALT APRI score) are nov...

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Autores principales: Alshuweishi, Yazeed, Alfaifi, Mohammed, Almoghrabi, Yousef, Alfhili, Mohammad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533151/
https://www.ncbi.nlm.nih.gov/pubmed/37763285
http://dx.doi.org/10.3390/life13091881
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author Alshuweishi, Yazeed
Alfaifi, Mohammed
Almoghrabi, Yousef
Alfhili, Mohammad A.
author_facet Alshuweishi, Yazeed
Alfaifi, Mohammed
Almoghrabi, Yousef
Alfhili, Mohammad A.
author_sort Alshuweishi, Yazeed
collection PubMed
description Background: Hyperglycemia is a common symptom of numerous conditions, most notably diabetes mellitus and Cushing’s syndrome, and the liver plays a pivotal role in the regulation of glucose metabolism. The AST–platelet ratio index (AST APRI score) and ALT–platelet ratio index (ALT APRI score) are novel parameters whose association with circulating glucose levels remains poorly studied. Methods: Laboratory data of 14,177 subjects were retrospectively analyzed for the association between AST and ALT APRI scores and fasting blood glucose (FBG) using the Mann–Whitney U and Kruskal–Wallis tests, Spearman’s rank correlation coefficient, prevalence and odds ratio (OR) and ROC curve analysis. Results: AST and ALT APRI scores showed progressive increases with FBG, and the mean FBG was significantly higher in subjects with high AST (104.9 ± 0.33 to 120.8 ± 3.27, p < 0.0001) and ALT (104.7 ± 0.34 to 111.6 ± 1.30, p < 0.0001) APRI scores. However, the AST APRI score but not the ALT APRI score was affected by age and gender. Notably, both elevated AST and ALT APRI scores were more prevalent in hyperglycemic subjects irrespective of gender and were associated with FBG, albeit through mediator variables. Increased AST (OR = 2.55, 95% CI: 1.46–2.06, p < 0.0001) and ALT (OR = 1.73, 95% CI: 1.46–2.06, p < 0.0001) APRI scores carried a significantly higher risk for hyperglycemia. Importantly, the ALT APRI score was superior to that of the AST APRI score in distinguishing hyperglycemic subjects. Conclusions: The AST and ALT APRI scores are inexpensive, novel markers of FBG and may serve as supportive evidence in the diagnosis and management of hyperglycemic conditions.
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spelling pubmed-105331512023-09-28 AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study Alshuweishi, Yazeed Alfaifi, Mohammed Almoghrabi, Yousef Alfhili, Mohammad A. Life (Basel) Article Background: Hyperglycemia is a common symptom of numerous conditions, most notably diabetes mellitus and Cushing’s syndrome, and the liver plays a pivotal role in the regulation of glucose metabolism. The AST–platelet ratio index (AST APRI score) and ALT–platelet ratio index (ALT APRI score) are novel parameters whose association with circulating glucose levels remains poorly studied. Methods: Laboratory data of 14,177 subjects were retrospectively analyzed for the association between AST and ALT APRI scores and fasting blood glucose (FBG) using the Mann–Whitney U and Kruskal–Wallis tests, Spearman’s rank correlation coefficient, prevalence and odds ratio (OR) and ROC curve analysis. Results: AST and ALT APRI scores showed progressive increases with FBG, and the mean FBG was significantly higher in subjects with high AST (104.9 ± 0.33 to 120.8 ± 3.27, p < 0.0001) and ALT (104.7 ± 0.34 to 111.6 ± 1.30, p < 0.0001) APRI scores. However, the AST APRI score but not the ALT APRI score was affected by age and gender. Notably, both elevated AST and ALT APRI scores were more prevalent in hyperglycemic subjects irrespective of gender and were associated with FBG, albeit through mediator variables. Increased AST (OR = 2.55, 95% CI: 1.46–2.06, p < 0.0001) and ALT (OR = 1.73, 95% CI: 1.46–2.06, p < 0.0001) APRI scores carried a significantly higher risk for hyperglycemia. Importantly, the ALT APRI score was superior to that of the AST APRI score in distinguishing hyperglycemic subjects. Conclusions: The AST and ALT APRI scores are inexpensive, novel markers of FBG and may serve as supportive evidence in the diagnosis and management of hyperglycemic conditions. MDPI 2023-09-07 /pmc/articles/PMC10533151/ /pubmed/37763285 http://dx.doi.org/10.3390/life13091881 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alshuweishi, Yazeed
Alfaifi, Mohammed
Almoghrabi, Yousef
Alfhili, Mohammad A.
AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study
title AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study
title_full AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study
title_fullStr AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study
title_full_unstemmed AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study
title_short AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study
title_sort ast and alt apri scores and dysglycemia in saudi arabia: a retrospective population study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533151/
https://www.ncbi.nlm.nih.gov/pubmed/37763285
http://dx.doi.org/10.3390/life13091881
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