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Variations in Theta/Beta Ratio and Cognitive Performance in Subpopulations of Subjects with ADHD Symptoms: Towards Neuropsychological Profiling for Patient Subgrouping

ADHD is a neurodevelopmental disorder appearing in childhood but remaining in many cases in adults. There are both pharmacological and non-pharmacological approaches to treating ADHD, but they do not have the same efficacy in all subjects. Better knowledge of the neurophysiological basis of this dis...

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Autores principales: Herrera-Morales, Wendy Verónica, Reyes-López, Julián Valeriano, Tuz-Castellanos, Karen Nicte-Ha, Ortegón-Abud, Desiree, Ramírez-Lugo, Leticia, Santiago-Rodríguez, Efraín, Núñez-Jaramillo, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533160/
https://www.ncbi.nlm.nih.gov/pubmed/37763129
http://dx.doi.org/10.3390/jpm13091361
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author Herrera-Morales, Wendy Verónica
Reyes-López, Julián Valeriano
Tuz-Castellanos, Karen Nicte-Ha
Ortegón-Abud, Desiree
Ramírez-Lugo, Leticia
Santiago-Rodríguez, Efraín
Núñez-Jaramillo, Luis
author_facet Herrera-Morales, Wendy Verónica
Reyes-López, Julián Valeriano
Tuz-Castellanos, Karen Nicte-Ha
Ortegón-Abud, Desiree
Ramírez-Lugo, Leticia
Santiago-Rodríguez, Efraín
Núñez-Jaramillo, Luis
author_sort Herrera-Morales, Wendy Verónica
collection PubMed
description ADHD is a neurodevelopmental disorder appearing in childhood but remaining in many cases in adults. There are both pharmacological and non-pharmacological approaches to treating ADHD, but they do not have the same efficacy in all subjects. Better knowledge of the neurophysiological basis of this disorder will allow for the design of more effective treatments. Studies performing qEEG analysis in children suggest the existence of subgroups of ADHD patients with different neurophysiological traits. There are fewer studies in adults, who might have undergone plastic changes allowing them to cope with ADHD symptoms along with brain maturation. Herein, we study cognitive performance and the theta/beta ratio in young adults with ADHD symptoms. We found that subjects with ADHD symptoms and low working memory performance (n = 30) present higher theta/beta ratios than controls (n = 40) at O2 and T6 in the eyes-closed condition, as well as a tendency toward a higher theta/beta ratio at O1 and Cz. Subjects with ADHD and high working memory performance (n = 50) do not differ from the controls in their theta/beta ratios at any derivation. Our results suggest that neuropsychological profiling could be useful for patient subgrouping. Further research will allow for the distinction of neuropsychological profiles and their neurophysiological correlates, leading to a better classification of ADHD subtypes, thus improving treatment selection.
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spelling pubmed-105331602023-09-28 Variations in Theta/Beta Ratio and Cognitive Performance in Subpopulations of Subjects with ADHD Symptoms: Towards Neuropsychological Profiling for Patient Subgrouping Herrera-Morales, Wendy Verónica Reyes-López, Julián Valeriano Tuz-Castellanos, Karen Nicte-Ha Ortegón-Abud, Desiree Ramírez-Lugo, Leticia Santiago-Rodríguez, Efraín Núñez-Jaramillo, Luis J Pers Med Article ADHD is a neurodevelopmental disorder appearing in childhood but remaining in many cases in adults. There are both pharmacological and non-pharmacological approaches to treating ADHD, but they do not have the same efficacy in all subjects. Better knowledge of the neurophysiological basis of this disorder will allow for the design of more effective treatments. Studies performing qEEG analysis in children suggest the existence of subgroups of ADHD patients with different neurophysiological traits. There are fewer studies in adults, who might have undergone plastic changes allowing them to cope with ADHD symptoms along with brain maturation. Herein, we study cognitive performance and the theta/beta ratio in young adults with ADHD symptoms. We found that subjects with ADHD symptoms and low working memory performance (n = 30) present higher theta/beta ratios than controls (n = 40) at O2 and T6 in the eyes-closed condition, as well as a tendency toward a higher theta/beta ratio at O1 and Cz. Subjects with ADHD and high working memory performance (n = 50) do not differ from the controls in their theta/beta ratios at any derivation. Our results suggest that neuropsychological profiling could be useful for patient subgrouping. Further research will allow for the distinction of neuropsychological profiles and their neurophysiological correlates, leading to a better classification of ADHD subtypes, thus improving treatment selection. MDPI 2023-09-07 /pmc/articles/PMC10533160/ /pubmed/37763129 http://dx.doi.org/10.3390/jpm13091361 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Herrera-Morales, Wendy Verónica
Reyes-López, Julián Valeriano
Tuz-Castellanos, Karen Nicte-Ha
Ortegón-Abud, Desiree
Ramírez-Lugo, Leticia
Santiago-Rodríguez, Efraín
Núñez-Jaramillo, Luis
Variations in Theta/Beta Ratio and Cognitive Performance in Subpopulations of Subjects with ADHD Symptoms: Towards Neuropsychological Profiling for Patient Subgrouping
title Variations in Theta/Beta Ratio and Cognitive Performance in Subpopulations of Subjects with ADHD Symptoms: Towards Neuropsychological Profiling for Patient Subgrouping
title_full Variations in Theta/Beta Ratio and Cognitive Performance in Subpopulations of Subjects with ADHD Symptoms: Towards Neuropsychological Profiling for Patient Subgrouping
title_fullStr Variations in Theta/Beta Ratio and Cognitive Performance in Subpopulations of Subjects with ADHD Symptoms: Towards Neuropsychological Profiling for Patient Subgrouping
title_full_unstemmed Variations in Theta/Beta Ratio and Cognitive Performance in Subpopulations of Subjects with ADHD Symptoms: Towards Neuropsychological Profiling for Patient Subgrouping
title_short Variations in Theta/Beta Ratio and Cognitive Performance in Subpopulations of Subjects with ADHD Symptoms: Towards Neuropsychological Profiling for Patient Subgrouping
title_sort variations in theta/beta ratio and cognitive performance in subpopulations of subjects with adhd symptoms: towards neuropsychological profiling for patient subgrouping
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533160/
https://www.ncbi.nlm.nih.gov/pubmed/37763129
http://dx.doi.org/10.3390/jpm13091361
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