Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells

In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells through an ‘inside out’ signalling process whereby structurally diverse phosphoantigen (pAg) molecules are sensed by the intracellular domain of butyrophilin BTN3A1(1–4). Here we show how—in both humans and alpaca—mu...

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Detalles Bibliográficos
Autores principales: Yuan, Linjie, Ma, Xianqiang, Yang, Yunyun, Qu, Yingying, Li, Xin, Zhu, Xiaoyu, Ma, Weiwei, Duan, Jianxin, Xue, Jing, Yang, Haoyu, Huang, Jian-Wen, Yi, Simin, Zhang, Mengting, Cai, Ningning, Zhang, Lin, Ding, Qingyang, Lai, Kecheng, Liu, Chang, Zhang, Lilan, Liu, Xinyi, Yao, Yirong, Zhou, Shuqi, Li, Xian, Shen, Panpan, Chang, Qing, Malwal, Satish R., He, Yuan, Li, Wenqi, Chen, Chunlai, Chen, Chun-Chi, Oldfield, Eric, Guo, Rey-Ting, Zhang, Yonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533412/
https://www.ncbi.nlm.nih.gov/pubmed/37674084
http://dx.doi.org/10.1038/s41586-023-06525-3

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