Cargando…

Patient-specific primary and pluripotent stem cell-derived stromal cells recapitulate key aspects of arrhythmogenic cardiomyopathy

Primary cardiac mesenchymal stromal cells (C-MSCs) can promote the aberrant remodeling of cardiac tissue that characterizes arrhythmogenic cardiomyopathy (ACM) by differentiating into adipocytes and myofibroblasts. These cells’ limitations, including restricted access to primary material and its man...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maione, Angela Serena, Meraviglia, Viviana, Iengo, Lara, Rabino, Martina, Chiesa, Mattia, Catto, Valentina, Tondo, Claudio, Pompilio, Giulio, Bellin, Milena, Sommariva, Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533531/ https://www.ncbi.nlm.nih.gov/pubmed/37758786 http://dx.doi.org/10.1038/s41598-023-43308-2

Ejemplares similares

Arrhythmogenic Cardiomyopathy: the Guilty Party in Adipogenesis
por: Stadiotti, Ilaria, et al.
Publicado: (2017)

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
por: Pilato, Chiara Assunta, et al.
Publicado: (2018)

Ca(2+) dysregulation in cardiac stromal cells sustains fibro-adipose remodeling in Arrhythmogenic Cardiomyopathy and can be modulated by flecainide
por: Maione, Angela S., et al.
Publicado: (2022)

Calcium as a Key Player in Arrhythmogenic Cardiomyopathy: Adhesion Disorder or Intracellular Alteration?
por: Moccia, Francesco, et al.
Publicado: (2019)

Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy
por: Sommariva, E., et al.
Publicado: (2016)

Cell models of arrhythmogenic cardiomyopathy: advances and opportunities
por: Sommariva, Elena, et al.
Publicado: (2017)

The arrhythmogenic cardiomyopathy-specific coding and non-coding transcriptome in human cardiac stromal cells
por: Rainer, Johannes, et al.
Publicado: (2018)

Metabolic Signature of Arrhythmogenic Cardiomyopathy
por: Volani, Chiara, et al.
Publicado: (2021)

Inflammation in the Pathogenesis of Arrhythmogenic Cardiomyopathy: Secondary Event or Active Driver?
por: Meraviglia, Viviana, et al.
Publicado: (2021)

Excess TGF-β1 Drives Cardiac Mesenchymal Stromal Cells to a Pro-Fibrotic Commitment in Arrhythmogenic Cardiomyopathy
por: Maione, Angela Serena, et al.
Publicado: (2021)

Fibrosis in Arrhythmogenic Cardiomyopathy: The Phantom Thread in the Fibro-Adipose Tissue
por: Maione, Angela Serena, et al.
Publicado: (2020)

Exploring digenic inheritance in arrhythmogenic cardiomyopathy
por: König, Eva, et al.
Publicado: (2017)

Cardiac Biomarkers and Autoantibodies in Endurance Athletes: Potential Similarities with Arrhythmogenic Cardiomyopathy Pathogenic Mechanisms
por: Stadiotti, Ilaria, et al.
Publicado: (2021)

From bedside to the bench: patient-specific hiPSC-EC models uncover endothelial dysfunction in genetic cardiomyopathies
por: Rabino, Martina, et al.
Publicado: (2023)

Mechanotransduction and Adrenergic Stimulation in Arrhythmogenic Cardiomyopathy: An Overview of in vitro and in vivo Models
por: Beffagna, Giorgia, et al.
Publicado: (2020)

Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy
por: Sommariva, Elena, et al.
Publicado: (2021)

Clinical and Molecular Data Define a Diagnosis of Arrhythmogenic Cardiomyopathy in a Carrier of a Brugada-Syndrome-Associated PKP2 Mutation
por: Persampieri, Simone, et al.
Publicado: (2020)

Omics Analyses of Stromal Cells from ACM Patients Reveal Alterations in Chromatin Organization and Mitochondrial Homeostasis
por: Lippi, Melania, et al.
Publicado: (2023)

Endomyocardial Biopsy: The Forgotten Piece in the Arrhythmogenic Cardiomyopathy Puzzle
por: Casella, Michela, et al.
Publicado: (2021)

Spectrum of Rare and Common Genetic Variants in Arrhythmogenic Cardiomyopathy Patients
por: Lippi, Melania, et al.
Publicado: (2022)

Derivation of human induced pluripotent stem cell line EURACi004-A from skin fibroblasts of a patient with Arrhythmogenic Cardiomyopathy carrying the heterozygous PKP2 mutation c.2569_3018del50
por: Ermon, Benedetta, et al.
Publicado: (2018)

GCN5 contributes to intracellular lipid accumulation in human primary cardiac stromal cells from patients affected by Arrhythmogenic cardiomyopathy
por: Volani, Chiara, et al.
Publicado: (2022)

MiR-320a as a Potential Novel Circulating Biomarker of Arrhythmogenic CardioMyopathy
por: Sommariva, Elena, et al.
Publicado: (2017)

Cyclophilin A in Arrhythmogenic Cardiomyopathy Cardiac Remodeling
por: Rurali, Erica, et al.
Publicado: (2019)

Modeling incomplete penetrance in arrhythmogenic cardiomyopathy by human induced pluripotent stem cell derived cardiomyocytes
por: De Bortoli, Marzia, et al.
Publicado: (2023)

Myocardial Inflammation as a Manifestation of Genetic Cardiomyopathies: From Bedside to the Bench
por: Peretto, Giovanni, et al.
Publicado: (2023)

Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis
por: Rabino, Martina, et al.
Publicado: (2023)

Syngeneic Cardiac and Bone Marrow Stromal Cells Display Tissue-Specific microRNA Signatures and microRNA Subsets Restricted to Diverse Differentiation Processes
por: Meraviglia, Viviana, et al.
Publicado: (2014)

Arrhythmogenic cardiomyopathy
por: Pilichou, Kalliopi, et al.
Publicado: (2016)

Human Cardiac Mesenchymal Stromal Cells From Right and Left Ventricles Display Differences in Number, Function, and Transcriptomic Profile
por: Stadiotti, Ilaria, et al.
Publicado: (2020)

Arrhythmogenic Cardiomyopathy Is a Multicellular Disease Affecting Cardiac and Bone Marrow Mesenchymal Stromal Cells
por: Scalco, Arianna, et al.
Publicado: (2021)

Arrhythmic risk prediction in arrhythmogenic right ventricular cardiomyopathy: external validation of the arrhythmogenic right ventricular cardiomyopathy risk calculator( )
por: Jordà, Paloma, et al.
Publicado: (2022)

Pregnancy in arrhythmogenic cardiomyopathy
por: Wichter, Thomas, et al.
Publicado: (2021)

Scarring/arrhythmogenic cardiomyopathy
por: Corrado, Domenico, et al.
Publicado: (2023)

Understanding Arrhythmogenic Cardiomyopathy: Advances through the Use of Human Pluripotent Stem Cell Models
por: Chua, Christianne J., et al.
Publicado: (2023)

Pressure Overload Activates DNA-Damage Response in Cardiac Stromal Cells: A Novel Mechanism Behind Heart Failure With Preserved Ejection Fraction?
por: Stadiotti, Ilaria, et al.
Publicado: (2022)

Arrhythmogenic right ventricular cardiomyopathy
por: Cho, Yongkeun
Publicado: (2018)

Arrhythmogenic left ventricular cardiomyopathy
por: Mirmomen, Seyedeh Mojdeh, et al.
Publicado: (2020)

Natural History of Arrhythmogenic Cardiomyopathy
por: Mattesi, Giulia, et al.
Publicado: (2020)

Arrhythmogenic left ventricular cardiomyopathy
por: Corrado, Domenico, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_br7m8tehud8nea5h2ag1hslgea