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Exposure to pesticides and risk of Hodgkin lymphoma in an international consortium of agricultural cohorts (AGRICOH)

PURPOSE: Some pesticides may increase the risk of certain lymphoid malignancies, but few studies have examined Hodgkin lymphoma (HL). In this exploratory study, we examined associations between agricultural use of 22 individual active ingredients and 13 chemical groups and HL incidence. METHODS: We...

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Autores principales: Kim, Joanne, Leon, Maria E., Schinasi, Leah H., Baldi, Isabelle, Lebailly, Pierre, Freeman, Laura E. Beane, Nordby, Karl-Christian, Ferro, Gilles, Monnereau, Alain, Brouwer, Maartje, Kjaerheim, Kristina, Hofmann, Jonathan N., Straif, Kurt, Kromhout, Hans, Schüz, Joachim, Togawa, Kayo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533587/
https://www.ncbi.nlm.nih.gov/pubmed/37418114
http://dx.doi.org/10.1007/s10552-023-01748-1
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author Kim, Joanne
Leon, Maria E.
Schinasi, Leah H.
Baldi, Isabelle
Lebailly, Pierre
Freeman, Laura E. Beane
Nordby, Karl-Christian
Ferro, Gilles
Monnereau, Alain
Brouwer, Maartje
Kjaerheim, Kristina
Hofmann, Jonathan N.
Straif, Kurt
Kromhout, Hans
Schüz, Joachim
Togawa, Kayo
author_facet Kim, Joanne
Leon, Maria E.
Schinasi, Leah H.
Baldi, Isabelle
Lebailly, Pierre
Freeman, Laura E. Beane
Nordby, Karl-Christian
Ferro, Gilles
Monnereau, Alain
Brouwer, Maartje
Kjaerheim, Kristina
Hofmann, Jonathan N.
Straif, Kurt
Kromhout, Hans
Schüz, Joachim
Togawa, Kayo
author_sort Kim, Joanne
collection PubMed
description PURPOSE: Some pesticides may increase the risk of certain lymphoid malignancies, but few studies have examined Hodgkin lymphoma (HL). In this exploratory study, we examined associations between agricultural use of 22 individual active ingredients and 13 chemical groups and HL incidence. METHODS: We used data from three agricultural cohorts participating in the AGRICOH consortium: the French Agriculture and Cancer Cohort (2005–2009), Cancer in the Norwegian Agricultural Population (1993–2011), and the US Agricultural Health Study (1993–2011). Lifetime pesticide use was estimated from crop-exposure matrices or self-report. Cohort-specific covariate-adjusted overall and age-specific (< 40 or ≥ 40 years) hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression and combined using random effects meta-analysis. RESULTS: Among 316 270 farmers (75% male) accumulating 3 574 815 person-years at risk, 91 incident cases of HL occurred. We did not observe statistically significant associations for any of the active ingredients or chemical groups studied. The highest risks of HL overall were observed for the pyrethroids deltamethrin (meta-HR = 1.86, 95% CI 0.76–4.52) and esfenvalerate (1.86, 0.78–4.43), and inverse associations of similar magnitude were observed for parathion and glyphosate. Risk of HL at ≥ 40 years of age was highest for ever-use of dicamba (2.04, 0.93–4.50) and lowest for glyphosate (0.46, 0.20–1.07). CONCLUSION: We report the largest prospective investigation of these associations. Nonetheless, low statistical power, a mixture of histological subtypes and a lack of information on tumour EBV status complicate the interpretability of the results. Most HL cases occurred at older ages, thus we could not explore associations with adolescent or young adult HL. Furthermore, estimates may be attenuated due to non-differential exposure misclassification. Future work should aim to extend follow-up and refine both exposure and outcome classification. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10552-023-01748-1.
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spelling pubmed-105335872023-09-29 Exposure to pesticides and risk of Hodgkin lymphoma in an international consortium of agricultural cohorts (AGRICOH) Kim, Joanne Leon, Maria E. Schinasi, Leah H. Baldi, Isabelle Lebailly, Pierre Freeman, Laura E. Beane Nordby, Karl-Christian Ferro, Gilles Monnereau, Alain Brouwer, Maartje Kjaerheim, Kristina Hofmann, Jonathan N. Straif, Kurt Kromhout, Hans Schüz, Joachim Togawa, Kayo Cancer Causes Control Original Paper PURPOSE: Some pesticides may increase the risk of certain lymphoid malignancies, but few studies have examined Hodgkin lymphoma (HL). In this exploratory study, we examined associations between agricultural use of 22 individual active ingredients and 13 chemical groups and HL incidence. METHODS: We used data from three agricultural cohorts participating in the AGRICOH consortium: the French Agriculture and Cancer Cohort (2005–2009), Cancer in the Norwegian Agricultural Population (1993–2011), and the US Agricultural Health Study (1993–2011). Lifetime pesticide use was estimated from crop-exposure matrices or self-report. Cohort-specific covariate-adjusted overall and age-specific (< 40 or ≥ 40 years) hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression and combined using random effects meta-analysis. RESULTS: Among 316 270 farmers (75% male) accumulating 3 574 815 person-years at risk, 91 incident cases of HL occurred. We did not observe statistically significant associations for any of the active ingredients or chemical groups studied. The highest risks of HL overall were observed for the pyrethroids deltamethrin (meta-HR = 1.86, 95% CI 0.76–4.52) and esfenvalerate (1.86, 0.78–4.43), and inverse associations of similar magnitude were observed for parathion and glyphosate. Risk of HL at ≥ 40 years of age was highest for ever-use of dicamba (2.04, 0.93–4.50) and lowest for glyphosate (0.46, 0.20–1.07). CONCLUSION: We report the largest prospective investigation of these associations. Nonetheless, low statistical power, a mixture of histological subtypes and a lack of information on tumour EBV status complicate the interpretability of the results. Most HL cases occurred at older ages, thus we could not explore associations with adolescent or young adult HL. Furthermore, estimates may be attenuated due to non-differential exposure misclassification. Future work should aim to extend follow-up and refine both exposure and outcome classification. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10552-023-01748-1. Springer International Publishing 2023-07-07 2023 /pmc/articles/PMC10533587/ /pubmed/37418114 http://dx.doi.org/10.1007/s10552-023-01748-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Kim, Joanne
Leon, Maria E.
Schinasi, Leah H.
Baldi, Isabelle
Lebailly, Pierre
Freeman, Laura E. Beane
Nordby, Karl-Christian
Ferro, Gilles
Monnereau, Alain
Brouwer, Maartje
Kjaerheim, Kristina
Hofmann, Jonathan N.
Straif, Kurt
Kromhout, Hans
Schüz, Joachim
Togawa, Kayo
Exposure to pesticides and risk of Hodgkin lymphoma in an international consortium of agricultural cohorts (AGRICOH)
title Exposure to pesticides and risk of Hodgkin lymphoma in an international consortium of agricultural cohorts (AGRICOH)
title_full Exposure to pesticides and risk of Hodgkin lymphoma in an international consortium of agricultural cohorts (AGRICOH)
title_fullStr Exposure to pesticides and risk of Hodgkin lymphoma in an international consortium of agricultural cohorts (AGRICOH)
title_full_unstemmed Exposure to pesticides and risk of Hodgkin lymphoma in an international consortium of agricultural cohorts (AGRICOH)
title_short Exposure to pesticides and risk of Hodgkin lymphoma in an international consortium of agricultural cohorts (AGRICOH)
title_sort exposure to pesticides and risk of hodgkin lymphoma in an international consortium of agricultural cohorts (agricoh)
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533587/
https://www.ncbi.nlm.nih.gov/pubmed/37418114
http://dx.doi.org/10.1007/s10552-023-01748-1
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