A meta-analytic review of the impact of ADHD medications on anxiety and depression in children and adolescents

Anxiety and depression are listed as common side effects for medications licensed for treating ADHD in children and adolescents. This meta-analytic review of randomised controlled trials aimed to explore the effect of medications on symptoms of anxiety and depression in children and adolescents with...

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Autores principales: Bryant, Annie, Schlesinger, Hope, Sideri, Athina, Holmes, Joni, Buitelaar, Jan, Meiser-Stedman, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Contribution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533622/
https://www.ncbi.nlm.nih.gov/pubmed/35616714
http://dx.doi.org/10.1007/s00787-022-02004-8
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author Bryant, Annie
Schlesinger, Hope
Sideri, Athina
Holmes, Joni
Buitelaar, Jan
Meiser-Stedman, Richard
author_facet Bryant, Annie
Schlesinger, Hope
Sideri, Athina
Holmes, Joni
Buitelaar, Jan
Meiser-Stedman, Richard
author_sort Bryant, Annie
collection PubMed
description Anxiety and depression are listed as common side effects for medications licensed for treating ADHD in children and adolescents. This meta-analytic review of randomised controlled trials aimed to explore the effect of medications on symptoms of anxiety and depression in children and adolescents with ADHD. A meta-analytic review of ADHD drug trials in children and adolescents was conducted. Random effects meta-analyses were conducted on anxiety and depression outcomes measured by validated psychological scales or side effect rating scales. Only 11% of eligible trials in this review reported anxiety and/or depression as an outcome or side effect, limiting the conclusions of the meta-analyses. Relative to placebo control, no significant effect of medication was found for symptoms of anxiety or depression in randomised controlled trials of ADHD medication in children and adolescents. This review highlights the systemic lack of mental health outcome reporting in child and adolescent ADHD drug trials. The importance of widespread implementation of standardised measurement of mental health outcomes in future trials is discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00787-022-02004-8.
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spelling pubmed-105336222023-09-29 A meta-analytic review of the impact of ADHD medications on anxiety and depression in children and adolescents Bryant, Annie Schlesinger, Hope Sideri, Athina Holmes, Joni Buitelaar, Jan Meiser-Stedman, Richard Eur Child Adolesc Psychiatry Original Contribution Anxiety and depression are listed as common side effects for medications licensed for treating ADHD in children and adolescents. This meta-analytic review of randomised controlled trials aimed to explore the effect of medications on symptoms of anxiety and depression in children and adolescents with ADHD. A meta-analytic review of ADHD drug trials in children and adolescents was conducted. Random effects meta-analyses were conducted on anxiety and depression outcomes measured by validated psychological scales or side effect rating scales. Only 11% of eligible trials in this review reported anxiety and/or depression as an outcome or side effect, limiting the conclusions of the meta-analyses. Relative to placebo control, no significant effect of medication was found for symptoms of anxiety or depression in randomised controlled trials of ADHD medication in children and adolescents. This review highlights the systemic lack of mental health outcome reporting in child and adolescent ADHD drug trials. The importance of widespread implementation of standardised measurement of mental health outcomes in future trials is discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00787-022-02004-8. Springer Berlin Heidelberg 2022-05-26 2023 /pmc/articles/PMC10533622/ /pubmed/35616714 http://dx.doi.org/10.1007/s00787-022-02004-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Contribution
Bryant, Annie
Schlesinger, Hope
Sideri, Athina
Holmes, Joni
Buitelaar, Jan
Meiser-Stedman, Richard
A meta-analytic review of the impact of ADHD medications on anxiety and depression in children and adolescents
title A meta-analytic review of the impact of ADHD medications on anxiety and depression in children and adolescents
title_full A meta-analytic review of the impact of ADHD medications on anxiety and depression in children and adolescents
title_fullStr A meta-analytic review of the impact of ADHD medications on anxiety and depression in children and adolescents
title_full_unstemmed A meta-analytic review of the impact of ADHD medications on anxiety and depression in children and adolescents
title_short A meta-analytic review of the impact of ADHD medications on anxiety and depression in children and adolescents
title_sort meta-analytic review of the impact of adhd medications on anxiety and depression in children and adolescents
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533622/
https://www.ncbi.nlm.nih.gov/pubmed/35616714
http://dx.doi.org/10.1007/s00787-022-02004-8
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