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The persistent effects of foetal growth on child and adolescent mental health: longitudinal evidence from a large population-based cohort
Low birth weight for one’s gestational age is associated with higher rates of child psychopathology, however, most studies assess psychopathology cross-sectionally. The effect of such foetal growth restriction appears to be strongest for attention problems in childhood, although adult studies have f...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533650/ https://www.ncbi.nlm.nih.gov/pubmed/35861893 http://dx.doi.org/10.1007/s00787-022-02045-z |
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author | Dooley, Niamh Healy, Colm Cotter, David Clarke, Mary Cannon, Mary |
author_facet | Dooley, Niamh Healy, Colm Cotter, David Clarke, Mary Cannon, Mary |
author_sort | Dooley, Niamh |
collection | PubMed |
description | Low birth weight for one’s gestational age is associated with higher rates of child psychopathology, however, most studies assess psychopathology cross-sectionally. The effect of such foetal growth restriction appears to be strongest for attention problems in childhood, although adult studies have found associations with a range of outcomes, from depression to psychosis. We explore how associations between foetal growth and psychopathology change across age, and whether they vary by sex. We used a large nationally representative cohort of children from Ireland (N ~ 8000). Parents completed the Strengths and Difficulties Questionnaire (SDQ) at 3 time points (age 9, 13 and 17). Outcomes included a total problems scale and subscales measuring attention/hyperactivity, peer, conduct and emotional problems. Foetal growth had significant associations with all problem scales, even after controlling for sex, socioeconomic factors and parental mental health. The magnitude of these effects was small but relatively stable across ages 9–17. In males, foetal growth had the strongest associations with attention/hyperactivity and peer problems, whereas females showed more widespread associations with all four subscales. There was a trend for the association between foetal growth and emotional problems to increase with advancing age, approaching the borderline-abnormal threshold by age 17. Reduced foetal growth predicted persistently higher scores on all measured aspects of child and adolescent psychopathology. Associations with child attention/hyperactivity may generalize to a wider array of adult psychopathologies via adolescent-onset emotional problems. Future studies should explore potential age-dependent effects of foetal growth into the early 20s. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00787-022-02045-z. |
format | Online Article Text |
id | pubmed-10533650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-105336502023-09-29 The persistent effects of foetal growth on child and adolescent mental health: longitudinal evidence from a large population-based cohort Dooley, Niamh Healy, Colm Cotter, David Clarke, Mary Cannon, Mary Eur Child Adolesc Psychiatry Original Contribution Low birth weight for one’s gestational age is associated with higher rates of child psychopathology, however, most studies assess psychopathology cross-sectionally. The effect of such foetal growth restriction appears to be strongest for attention problems in childhood, although adult studies have found associations with a range of outcomes, from depression to psychosis. We explore how associations between foetal growth and psychopathology change across age, and whether they vary by sex. We used a large nationally representative cohort of children from Ireland (N ~ 8000). Parents completed the Strengths and Difficulties Questionnaire (SDQ) at 3 time points (age 9, 13 and 17). Outcomes included a total problems scale and subscales measuring attention/hyperactivity, peer, conduct and emotional problems. Foetal growth had significant associations with all problem scales, even after controlling for sex, socioeconomic factors and parental mental health. The magnitude of these effects was small but relatively stable across ages 9–17. In males, foetal growth had the strongest associations with attention/hyperactivity and peer problems, whereas females showed more widespread associations with all four subscales. There was a trend for the association between foetal growth and emotional problems to increase with advancing age, approaching the borderline-abnormal threshold by age 17. Reduced foetal growth predicted persistently higher scores on all measured aspects of child and adolescent psychopathology. Associations with child attention/hyperactivity may generalize to a wider array of adult psychopathologies via adolescent-onset emotional problems. Future studies should explore potential age-dependent effects of foetal growth into the early 20s. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00787-022-02045-z. Springer Berlin Heidelberg 2022-07-21 2023 /pmc/articles/PMC10533650/ /pubmed/35861893 http://dx.doi.org/10.1007/s00787-022-02045-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Contribution Dooley, Niamh Healy, Colm Cotter, David Clarke, Mary Cannon, Mary The persistent effects of foetal growth on child and adolescent mental health: longitudinal evidence from a large population-based cohort |
title | The persistent effects of foetal growth on child and adolescent mental health: longitudinal evidence from a large population-based cohort |
title_full | The persistent effects of foetal growth on child and adolescent mental health: longitudinal evidence from a large population-based cohort |
title_fullStr | The persistent effects of foetal growth on child and adolescent mental health: longitudinal evidence from a large population-based cohort |
title_full_unstemmed | The persistent effects of foetal growth on child and adolescent mental health: longitudinal evidence from a large population-based cohort |
title_short | The persistent effects of foetal growth on child and adolescent mental health: longitudinal evidence from a large population-based cohort |
title_sort | persistent effects of foetal growth on child and adolescent mental health: longitudinal evidence from a large population-based cohort |
topic | Original Contribution |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533650/ https://www.ncbi.nlm.nih.gov/pubmed/35861893 http://dx.doi.org/10.1007/s00787-022-02045-z |
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