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Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO)

INTRODUCTION: Very preterm infants are at risk of abnormal microbiome colonisation in the first weeks to months of life. Several important associated factors have been identified including gestational age, mode of delivery, antibiotic exposure and feeding. Preterm infants are at risk of a number of...

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Autores principales: Healy, David, Wang, Shuo, Grimaud, Ghjuvan, Warda, Alicja Katarzyna, Ross, Paul, Stanton, Catherine, Dempsey, Eugene M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533688/
https://www.ncbi.nlm.nih.gov/pubmed/37748849
http://dx.doi.org/10.1136/bmjopen-2023-075060
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author Healy, David
Wang, Shuo
Grimaud, Ghjuvan
Warda, Alicja Katarzyna
Ross, Paul
Stanton, Catherine
Dempsey, Eugene M
author_facet Healy, David
Wang, Shuo
Grimaud, Ghjuvan
Warda, Alicja Katarzyna
Ross, Paul
Stanton, Catherine
Dempsey, Eugene M
author_sort Healy, David
collection PubMed
description INTRODUCTION: Very preterm infants are at risk of abnormal microbiome colonisation in the first weeks to months of life. Several important associated factors have been identified including gestational age, mode of delivery, antibiotic exposure and feeding. Preterm infants are at risk of a number of pathologies for which the microbiome may play a central role, including necrotising enterocolitis and sepsis. The objective of this study is to determine detailed microbiome changes that occur around implementation of different management practices including empiric antibiotic use, advancement of feeds and administration of probiotics during admission to the neonatal intensive care unit. METHODS AND ANALYSIS: A single-site, longitudinal observational study of infants born less than 32 weeks gestation, including collection of maternal samples around delivery and breastmilk and infant samples from admission through discharge from the neonatal unit. ETHICS AND DISSEMINATION: The protocol was approved by the Clinical Research Ethics Committee of the Cork Teaching Hospitals. The findings from this study will be disseminated in peer-reviewed journals, during scientific conferences, and directly to the study participants. Sequencing data will be deposited in public databases. TRIAL REGISTRATION NUMBER: NCT05803577.
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spelling pubmed-105336882023-09-29 Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO) Healy, David Wang, Shuo Grimaud, Ghjuvan Warda, Alicja Katarzyna Ross, Paul Stanton, Catherine Dempsey, Eugene M BMJ Open Paediatrics INTRODUCTION: Very preterm infants are at risk of abnormal microbiome colonisation in the first weeks to months of life. Several important associated factors have been identified including gestational age, mode of delivery, antibiotic exposure and feeding. Preterm infants are at risk of a number of pathologies for which the microbiome may play a central role, including necrotising enterocolitis and sepsis. The objective of this study is to determine detailed microbiome changes that occur around implementation of different management practices including empiric antibiotic use, advancement of feeds and administration of probiotics during admission to the neonatal intensive care unit. METHODS AND ANALYSIS: A single-site, longitudinal observational study of infants born less than 32 weeks gestation, including collection of maternal samples around delivery and breastmilk and infant samples from admission through discharge from the neonatal unit. ETHICS AND DISSEMINATION: The protocol was approved by the Clinical Research Ethics Committee of the Cork Teaching Hospitals. The findings from this study will be disseminated in peer-reviewed journals, during scientific conferences, and directly to the study participants. Sequencing data will be deposited in public databases. TRIAL REGISTRATION NUMBER: NCT05803577. BMJ Publishing Group 2023-09-25 /pmc/articles/PMC10533688/ /pubmed/37748849 http://dx.doi.org/10.1136/bmjopen-2023-075060 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Paediatrics
Healy, David
Wang, Shuo
Grimaud, Ghjuvan
Warda, Alicja Katarzyna
Ross, Paul
Stanton, Catherine
Dempsey, Eugene M
Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO)
title Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO)
title_full Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO)
title_fullStr Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO)
title_full_unstemmed Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO)
title_short Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO)
title_sort longitudinal observational study protocol – preterm infants: microbiome establishment, neuro-crosstalk and origins (pimento)
topic Paediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533688/
https://www.ncbi.nlm.nih.gov/pubmed/37748849
http://dx.doi.org/10.1136/bmjopen-2023-075060
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