Branch retinal vein occlusion in a case of recalcitrant diffuse anterior scleritis treated with tofacitinib

A 47-year-old woman with hypertension and rheumatoid arthritis presented with non-necrotizing scleritis in both eyes. Despite a course of oral corticosteroids, she continued to experience persistent symptoms. A rheumatologist was consulted and initiated treatment with tofacitinib, a JAK/STAT inhibit...

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Autores principales: Manoharan, Anitha, Atmakur, Harshita, Dutta Majumder, Parthopratim, Biswas, Jyotirmay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533758/
https://www.ncbi.nlm.nih.gov/pubmed/37755540
http://dx.doi.org/10.1186/s12348-023-00359-w
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author Manoharan, Anitha
Atmakur, Harshita
Dutta Majumder, Parthopratim
Biswas, Jyotirmay
author_facet Manoharan, Anitha
Atmakur, Harshita
Dutta Majumder, Parthopratim
Biswas, Jyotirmay
author_sort Manoharan, Anitha
collection PubMed
description A 47-year-old woman with hypertension and rheumatoid arthritis presented with non-necrotizing scleritis in both eyes. Despite a course of oral corticosteroids, she continued to experience persistent symptoms. A rheumatologist was consulted and initiated treatment with tofacitinib, a JAK/STAT inhibitor. Treatment with tofacitinib and oral corticosteroids resulted in an improvement in the scleritis in both eyes. However, a fundus examination of her left eye revealed a superior-temporal branch retinal vein occlusion. Given the growing concern regarding the increased risk of thromboembolic events with tofacitinib therapy, it is essential to consider the risk of retinal vascular occlusions when starting tofacitinib therapy, particularly in patients with underlying systemic comorbidities.
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spelling pubmed-105337582023-09-29 Branch retinal vein occlusion in a case of recalcitrant diffuse anterior scleritis treated with tofacitinib Manoharan, Anitha Atmakur, Harshita Dutta Majumder, Parthopratim Biswas, Jyotirmay J Ophthalmic Inflamm Infect Brief Report A 47-year-old woman with hypertension and rheumatoid arthritis presented with non-necrotizing scleritis in both eyes. Despite a course of oral corticosteroids, she continued to experience persistent symptoms. A rheumatologist was consulted and initiated treatment with tofacitinib, a JAK/STAT inhibitor. Treatment with tofacitinib and oral corticosteroids resulted in an improvement in the scleritis in both eyes. However, a fundus examination of her left eye revealed a superior-temporal branch retinal vein occlusion. Given the growing concern regarding the increased risk of thromboembolic events with tofacitinib therapy, it is essential to consider the risk of retinal vascular occlusions when starting tofacitinib therapy, particularly in patients with underlying systemic comorbidities. Springer Berlin Heidelberg 2023-09-27 /pmc/articles/PMC10533758/ /pubmed/37755540 http://dx.doi.org/10.1186/s12348-023-00359-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Manoharan, Anitha
Atmakur, Harshita
Dutta Majumder, Parthopratim
Biswas, Jyotirmay
Branch retinal vein occlusion in a case of recalcitrant diffuse anterior scleritis treated with tofacitinib
title Branch retinal vein occlusion in a case of recalcitrant diffuse anterior scleritis treated with tofacitinib
title_full Branch retinal vein occlusion in a case of recalcitrant diffuse anterior scleritis treated with tofacitinib
title_fullStr Branch retinal vein occlusion in a case of recalcitrant diffuse anterior scleritis treated with tofacitinib
title_full_unstemmed Branch retinal vein occlusion in a case of recalcitrant diffuse anterior scleritis treated with tofacitinib
title_short Branch retinal vein occlusion in a case of recalcitrant diffuse anterior scleritis treated with tofacitinib
title_sort branch retinal vein occlusion in a case of recalcitrant diffuse anterior scleritis treated with tofacitinib
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533758/
https://www.ncbi.nlm.nih.gov/pubmed/37755540
http://dx.doi.org/10.1186/s12348-023-00359-w
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AT duttamajumderparthopratim branchretinalveinocclusioninacaseofrecalcitrantdiffuseanteriorscleritistreatedwithtofacitinib
AT biswasjyotirmay branchretinalveinocclusioninacaseofrecalcitrantdiffuseanteriorscleritistreatedwithtofacitinib

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