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Gliotoxin-mediated bacterial growth inhibition is caused by specific metal ion depletion

Overcoming antimicrobial resistance represents a formidable challenge and investigating bacterial growth inhibition by fungal metabolites may yield new strategies. Although the fungal non-ribosomal peptide gliotoxin (GT) is known to exhibit antibacterial activity, the mechanism(s) of action are unkn...

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Detalles Bibliográficos
Autores principales: Downes, Shane G., Owens, Rebecca A., Walshe, Kieran, Fitzpatrick, David A., Dorey, Amber, Jones, Gary W., Doyle, Sean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533825/
https://www.ncbi.nlm.nih.gov/pubmed/37758814
http://dx.doi.org/10.1038/s41598-023-43300-w