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Induction of broad multifunctional CD8+ and CD4+ T cells by hepatitis B virus antigen-based synthetic long peptides ex vivo

INTRODUCTION: Therapeutic vaccination based on synthetic long peptides (SLP(®)) containing both CD4+ and CD8+ T cell epitopes is a promising treatment strategy for chronic hepatitis B infection (cHBV). METHODS: We designed SLPs for three HBV proteins, HBcAg and the non-secreted proteins polymerase a...

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Detalles Bibliográficos
Autores principales:	Jansen, Diahann T. S. L., de Beijer, Monique T. A., Luijten, Robbie J., Kwappenberg, Kitty, Wiekmeijer, Anna-Sophia, Kessler, Amy L., Pieterman, Roel F. A., Bouzid, Rachid, Krebber, Willem-Jan, de Man, Robert A., Melief, Cornelis J. M., Buschow, Sonja I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534072/ https://www.ncbi.nlm.nih.gov/pubmed/37781393 http://dx.doi.org/10.3389/fimmu.2023.1163118

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