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A Chicken Tapasin ortholog can chaperone empty HLA-B∗37:01 molecules independent of other peptide-loading components

Human Tapasin (hTapasin) is the main chaperone of MHC-I molecules, enabling peptide loading and antigen repertoire optimization across HLA allotypes. However, it is restricted to the endoplasmic reticulum (ER) lumen as part of the protein loading complex (PLC), and therefore is highly unstable when...

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Detalles Bibliográficos
Autores principales:	Papadaki, Georgia F., Woodward, Claire H., Young, Michael C., Winters, Trenton J., Burslem, George M., Sgourakis, Nikolaos G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	JBC Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534222/ https://www.ncbi.nlm.nih.gov/pubmed/37543367 http://dx.doi.org/10.1016/j.jbc.2023.105136

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