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Melatonin Use in Pediatric Intensive Care Units: A Single-Center Experience
Growing evidence indicates that altered melatonin secretion during critical illness may influence the quality and quantity of sleep, delirium, and overall recovery. However, limited data exist regarding the use of melatonin in pediatric critical illness. Data were reviewed over a 5-year period at a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534299/ https://www.ncbi.nlm.nih.gov/pubmed/37755159 http://dx.doi.org/10.3390/medsci11030055 |
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author | Jacobson, Jessica L. Tylka, Joanna Glazer, Savannah Zhang, Yanyu Cosme, Rosario Silvestri, Jean M. Patwari, Pallavi P. |
author_facet | Jacobson, Jessica L. Tylka, Joanna Glazer, Savannah Zhang, Yanyu Cosme, Rosario Silvestri, Jean M. Patwari, Pallavi P. |
author_sort | Jacobson, Jessica L. |
collection | PubMed |
description | Growing evidence indicates that altered melatonin secretion during critical illness may influence the quality and quantity of sleep, delirium, and overall recovery. However, limited data exist regarding the use of melatonin in pediatric critical illness. Data were reviewed over a 5-year period at a tertiary pediatric intensive care unit for pediatric patients (ages 0–18 years) who were prescribed melatonin with the aim of identifying the frequency of and indications for use. Data collection included the hospital day of initiation, the dose, the frequency, the duration of use, and the length of stay. The results demonstrate that melatonin was infrequently prescribed (6.0% of patients admitted; n = 182) and that the majority of patients received melatonin as continuation of home medication (46%; n = 83 of 182). This group had significantly earlier melatonin use (0.9 ± 2.3 day of hospitalization; p < 0.0001) and significantly reduced lengths of stay compared to the other groups (mean LOS 7.2 ± 9.3 days; p < 0.0001). Frequently, clear documentation of indication for melatonin use was absent (20%; n = 37). In conclusion, given that melatonin is infrequently used within a tertiary PICU with the most common indication as the continuation of home medication, and often without clear documentation for indication, this presents an opportunity to emphasize a more attentive and strategic approach regarding melatonin use in the PICU population. |
format | Online Article Text |
id | pubmed-10534299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105342992023-09-29 Melatonin Use in Pediatric Intensive Care Units: A Single-Center Experience Jacobson, Jessica L. Tylka, Joanna Glazer, Savannah Zhang, Yanyu Cosme, Rosario Silvestri, Jean M. Patwari, Pallavi P. Med Sci (Basel) Article Growing evidence indicates that altered melatonin secretion during critical illness may influence the quality and quantity of sleep, delirium, and overall recovery. However, limited data exist regarding the use of melatonin in pediatric critical illness. Data were reviewed over a 5-year period at a tertiary pediatric intensive care unit for pediatric patients (ages 0–18 years) who were prescribed melatonin with the aim of identifying the frequency of and indications for use. Data collection included the hospital day of initiation, the dose, the frequency, the duration of use, and the length of stay. The results demonstrate that melatonin was infrequently prescribed (6.0% of patients admitted; n = 182) and that the majority of patients received melatonin as continuation of home medication (46%; n = 83 of 182). This group had significantly earlier melatonin use (0.9 ± 2.3 day of hospitalization; p < 0.0001) and significantly reduced lengths of stay compared to the other groups (mean LOS 7.2 ± 9.3 days; p < 0.0001). Frequently, clear documentation of indication for melatonin use was absent (20%; n = 37). In conclusion, given that melatonin is infrequently used within a tertiary PICU with the most common indication as the continuation of home medication, and often without clear documentation for indication, this presents an opportunity to emphasize a more attentive and strategic approach regarding melatonin use in the PICU population. MDPI 2023-08-28 /pmc/articles/PMC10534299/ /pubmed/37755159 http://dx.doi.org/10.3390/medsci11030055 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jacobson, Jessica L. Tylka, Joanna Glazer, Savannah Zhang, Yanyu Cosme, Rosario Silvestri, Jean M. Patwari, Pallavi P. Melatonin Use in Pediatric Intensive Care Units: A Single-Center Experience |
title | Melatonin Use in Pediatric Intensive Care Units: A Single-Center Experience |
title_full | Melatonin Use in Pediatric Intensive Care Units: A Single-Center Experience |
title_fullStr | Melatonin Use in Pediatric Intensive Care Units: A Single-Center Experience |
title_full_unstemmed | Melatonin Use in Pediatric Intensive Care Units: A Single-Center Experience |
title_short | Melatonin Use in Pediatric Intensive Care Units: A Single-Center Experience |
title_sort | melatonin use in pediatric intensive care units: a single-center experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534299/ https://www.ncbi.nlm.nih.gov/pubmed/37755159 http://dx.doi.org/10.3390/medsci11030055 |
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