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The Association between Gut Microbiota and Depression in the Japanese Population

Depression is a leading cause of disease worldwide. The association between gut microbiota and depression has barely been investigated in the Japanese population. We analyzed Iwaki health check-up data collected from 2017 to 2019 and constructed generalized linear mixed models. The independent varia...

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Autores principales: Yang, Yichi, Mori, Mone, Wai, Kyi Mar, Jiang, Tao, Sugimura, Yoshikuni, Munakata, Wataru, Mikami, Tatsuya, Murashita, Koichi, Nakaji, Shigeyuki, Ihara, Kazushige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534301/
https://www.ncbi.nlm.nih.gov/pubmed/37764129
http://dx.doi.org/10.3390/microorganisms11092286
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author Yang, Yichi
Mori, Mone
Wai, Kyi Mar
Jiang, Tao
Sugimura, Yoshikuni
Munakata, Wataru
Mikami, Tatsuya
Murashita, Koichi
Nakaji, Shigeyuki
Ihara, Kazushige
author_facet Yang, Yichi
Mori, Mone
Wai, Kyi Mar
Jiang, Tao
Sugimura, Yoshikuni
Munakata, Wataru
Mikami, Tatsuya
Murashita, Koichi
Nakaji, Shigeyuki
Ihara, Kazushige
author_sort Yang, Yichi
collection PubMed
description Depression is a leading cause of disease worldwide. The association between gut microbiota and depression has barely been investigated in the Japanese population. We analyzed Iwaki health check-up data collected from 2017 to 2019 and constructed generalized linear mixed models. The independent variable was the relative abundance of each of the 37 gut microbiota genera that were reported to be associated with depression. The dependent variable was the presence of depression assessed by the Center for Epidemiologic Studies Depression Scale. Potential confounders, including grip strength, gender, height, weight, smoking, and drinking habits, were adjusted in the regression models. Nine genera’s regression coefficients (Alistipes, Blautia, Coprococcus, Dorea, Faecalibacterium, Holdemania, Lactobacillus, Mitsuokella, and Oscillibacter) showed statistical significance after multiple comparisons adjustment. Among these nine gut bacteria genera, Alistipes, Blautia, Coprococcus, Dorea, Faecalibacterium, and Oscillibacter were reported to be associated with butyrate production in the intestine. Our results indicate that gut microbiotas may influence the depression condition of the host via the butyrate-producing process.
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spelling pubmed-105343012023-09-29 The Association between Gut Microbiota and Depression in the Japanese Population Yang, Yichi Mori, Mone Wai, Kyi Mar Jiang, Tao Sugimura, Yoshikuni Munakata, Wataru Mikami, Tatsuya Murashita, Koichi Nakaji, Shigeyuki Ihara, Kazushige Microorganisms Article Depression is a leading cause of disease worldwide. The association between gut microbiota and depression has barely been investigated in the Japanese population. We analyzed Iwaki health check-up data collected from 2017 to 2019 and constructed generalized linear mixed models. The independent variable was the relative abundance of each of the 37 gut microbiota genera that were reported to be associated with depression. The dependent variable was the presence of depression assessed by the Center for Epidemiologic Studies Depression Scale. Potential confounders, including grip strength, gender, height, weight, smoking, and drinking habits, were adjusted in the regression models. Nine genera’s regression coefficients (Alistipes, Blautia, Coprococcus, Dorea, Faecalibacterium, Holdemania, Lactobacillus, Mitsuokella, and Oscillibacter) showed statistical significance after multiple comparisons adjustment. Among these nine gut bacteria genera, Alistipes, Blautia, Coprococcus, Dorea, Faecalibacterium, and Oscillibacter were reported to be associated with butyrate production in the intestine. Our results indicate that gut microbiotas may influence the depression condition of the host via the butyrate-producing process. MDPI 2023-09-11 /pmc/articles/PMC10534301/ /pubmed/37764129 http://dx.doi.org/10.3390/microorganisms11092286 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Yichi
Mori, Mone
Wai, Kyi Mar
Jiang, Tao
Sugimura, Yoshikuni
Munakata, Wataru
Mikami, Tatsuya
Murashita, Koichi
Nakaji, Shigeyuki
Ihara, Kazushige
The Association between Gut Microbiota and Depression in the Japanese Population
title The Association between Gut Microbiota and Depression in the Japanese Population
title_full The Association between Gut Microbiota and Depression in the Japanese Population
title_fullStr The Association between Gut Microbiota and Depression in the Japanese Population
title_full_unstemmed The Association between Gut Microbiota and Depression in the Japanese Population
title_short The Association between Gut Microbiota and Depression in the Japanese Population
title_sort association between gut microbiota and depression in the japanese population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534301/
https://www.ncbi.nlm.nih.gov/pubmed/37764129
http://dx.doi.org/10.3390/microorganisms11092286
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