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Ochratoxin A—The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention
Ochratoxin A (OTA) is considered as the most toxic of the other ochratoxins synthesized by various fungal species belonging to the Aspergillus and Penicillium families. OTA commonly contaminates food and beverages, resulting in animal and human health issues. The toxicity of OTA is known to cause li...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534339/ https://www.ncbi.nlm.nih.gov/pubmed/37764392 http://dx.doi.org/10.3390/molecules28186617 |
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author | Więckowska, Magdalena Szelenberger, Rafał Niemcewicz, Marcin Harmata, Piotr Poplawski, Tomasz Bijak, Michał |
author_facet | Więckowska, Magdalena Szelenberger, Rafał Niemcewicz, Marcin Harmata, Piotr Poplawski, Tomasz Bijak, Michał |
author_sort | Więckowska, Magdalena |
collection | PubMed |
description | Ochratoxin A (OTA) is considered as the most toxic of the other ochratoxins synthesized by various fungal species belonging to the Aspergillus and Penicillium families. OTA commonly contaminates food and beverages, resulting in animal and human health issues. The toxicity of OTA is known to cause liver damage and is still being researched. However, current findings do not provide clear insights into the toxin mechanism of action. The current studies focusing on the use of potentially protective compounds against the effects of the toxin are insufficient as they are mainly conducted on animals. Further research is required to fill the existing gaps in both fields (namely the exact OTA molecular mechanism and the prevention of its toxicity in the human liver). This review article is a summary of the so far obtained results of studies focusing on the OTA hepatotoxicity, its mode of action, and the known approaches of liver cells protection, which may be the base for expanding other research in near future. |
format | Online Article Text |
id | pubmed-10534339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105343392023-09-29 Ochratoxin A—The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention Więckowska, Magdalena Szelenberger, Rafał Niemcewicz, Marcin Harmata, Piotr Poplawski, Tomasz Bijak, Michał Molecules Review Ochratoxin A (OTA) is considered as the most toxic of the other ochratoxins synthesized by various fungal species belonging to the Aspergillus and Penicillium families. OTA commonly contaminates food and beverages, resulting in animal and human health issues. The toxicity of OTA is known to cause liver damage and is still being researched. However, current findings do not provide clear insights into the toxin mechanism of action. The current studies focusing on the use of potentially protective compounds against the effects of the toxin are insufficient as they are mainly conducted on animals. Further research is required to fill the existing gaps in both fields (namely the exact OTA molecular mechanism and the prevention of its toxicity in the human liver). This review article is a summary of the so far obtained results of studies focusing on the OTA hepatotoxicity, its mode of action, and the known approaches of liver cells protection, which may be the base for expanding other research in near future. MDPI 2023-09-14 /pmc/articles/PMC10534339/ /pubmed/37764392 http://dx.doi.org/10.3390/molecules28186617 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Więckowska, Magdalena Szelenberger, Rafał Niemcewicz, Marcin Harmata, Piotr Poplawski, Tomasz Bijak, Michał Ochratoxin A—The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention |
title | Ochratoxin A—The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention |
title_full | Ochratoxin A—The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention |
title_fullStr | Ochratoxin A—The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention |
title_full_unstemmed | Ochratoxin A—The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention |
title_short | Ochratoxin A—The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention |
title_sort | ochratoxin a—the current knowledge concerning hepatotoxicity, mode of action and possible prevention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534339/ https://www.ncbi.nlm.nih.gov/pubmed/37764392 http://dx.doi.org/10.3390/molecules28186617 |
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