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Cyclodextrins as Multi-Functional Ingredients in Dentistry
Cyclodextrins are present in a variety of oral hygiene compositions. The present work describes the role of cyclodextrins in several toothpastes and mouthwashes that are already available in the market, as well as their prospective use in other applications as investigated in studies in the literatu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534413/ https://www.ncbi.nlm.nih.gov/pubmed/37765220 http://dx.doi.org/10.3390/pharmaceutics15092251 |
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author | Braga, Susana Santos |
author_facet | Braga, Susana Santos |
author_sort | Braga, Susana Santos |
collection | PubMed |
description | Cyclodextrins are present in a variety of oral hygiene compositions. The present work describes the role of cyclodextrins in several toothpastes and mouthwashes that are already available in the market, as well as their prospective use in other applications as investigated in studies in the literature. Moreover, cyclodextrins are under study for the development of materials used in various techniques of dental repair, such as fillings, cements and binders therein. Their role in each of the innovative materials is presented. Finally, the prospect of the use of cyclodextrin-based delivery systems for the oral cavity is introduced, with a focus on new cyclodextrin molecules with dual action as bone-targeting agents and osteogenic drugs, and on new cross-linked cyclodextrin particles with a high drug loading and sustained drug delivery profile for the treatment of diseases that require prolonged action, such as periodontitis. In conclusion, cyclodextrins are herein demonstrated to act as versatile and multi-action ingredients with a broad range of applications in dentistry. |
format | Online Article Text |
id | pubmed-10534413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105344132023-09-29 Cyclodextrins as Multi-Functional Ingredients in Dentistry Braga, Susana Santos Pharmaceutics Review Cyclodextrins are present in a variety of oral hygiene compositions. The present work describes the role of cyclodextrins in several toothpastes and mouthwashes that are already available in the market, as well as their prospective use in other applications as investigated in studies in the literature. Moreover, cyclodextrins are under study for the development of materials used in various techniques of dental repair, such as fillings, cements and binders therein. Their role in each of the innovative materials is presented. Finally, the prospect of the use of cyclodextrin-based delivery systems for the oral cavity is introduced, with a focus on new cyclodextrin molecules with dual action as bone-targeting agents and osteogenic drugs, and on new cross-linked cyclodextrin particles with a high drug loading and sustained drug delivery profile for the treatment of diseases that require prolonged action, such as periodontitis. In conclusion, cyclodextrins are herein demonstrated to act as versatile and multi-action ingredients with a broad range of applications in dentistry. MDPI 2023-08-31 /pmc/articles/PMC10534413/ /pubmed/37765220 http://dx.doi.org/10.3390/pharmaceutics15092251 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Braga, Susana Santos Cyclodextrins as Multi-Functional Ingredients in Dentistry |
title | Cyclodextrins as Multi-Functional Ingredients in Dentistry |
title_full | Cyclodextrins as Multi-Functional Ingredients in Dentistry |
title_fullStr | Cyclodextrins as Multi-Functional Ingredients in Dentistry |
title_full_unstemmed | Cyclodextrins as Multi-Functional Ingredients in Dentistry |
title_short | Cyclodextrins as Multi-Functional Ingredients in Dentistry |
title_sort | cyclodextrins as multi-functional ingredients in dentistry |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534413/ https://www.ncbi.nlm.nih.gov/pubmed/37765220 http://dx.doi.org/10.3390/pharmaceutics15092251 |
work_keys_str_mv | AT bragasusanasantos cyclodextrinsasmultifunctionalingredientsindentistry |