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Cyclodextrins as Multi-Functional Ingredients in Dentistry

Cyclodextrins are present in a variety of oral hygiene compositions. The present work describes the role of cyclodextrins in several toothpastes and mouthwashes that are already available in the market, as well as their prospective use in other applications as investigated in studies in the literatu...

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Autor principal: Braga, Susana Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534413/
https://www.ncbi.nlm.nih.gov/pubmed/37765220
http://dx.doi.org/10.3390/pharmaceutics15092251
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author Braga, Susana Santos
author_facet Braga, Susana Santos
author_sort Braga, Susana Santos
collection PubMed
description Cyclodextrins are present in a variety of oral hygiene compositions. The present work describes the role of cyclodextrins in several toothpastes and mouthwashes that are already available in the market, as well as their prospective use in other applications as investigated in studies in the literature. Moreover, cyclodextrins are under study for the development of materials used in various techniques of dental repair, such as fillings, cements and binders therein. Their role in each of the innovative materials is presented. Finally, the prospect of the use of cyclodextrin-based delivery systems for the oral cavity is introduced, with a focus on new cyclodextrin molecules with dual action as bone-targeting agents and osteogenic drugs, and on new cross-linked cyclodextrin particles with a high drug loading and sustained drug delivery profile for the treatment of diseases that require prolonged action, such as periodontitis. In conclusion, cyclodextrins are herein demonstrated to act as versatile and multi-action ingredients with a broad range of applications in dentistry.
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spelling pubmed-105344132023-09-29 Cyclodextrins as Multi-Functional Ingredients in Dentistry Braga, Susana Santos Pharmaceutics Review Cyclodextrins are present in a variety of oral hygiene compositions. The present work describes the role of cyclodextrins in several toothpastes and mouthwashes that are already available in the market, as well as their prospective use in other applications as investigated in studies in the literature. Moreover, cyclodextrins are under study for the development of materials used in various techniques of dental repair, such as fillings, cements and binders therein. Their role in each of the innovative materials is presented. Finally, the prospect of the use of cyclodextrin-based delivery systems for the oral cavity is introduced, with a focus on new cyclodextrin molecules with dual action as bone-targeting agents and osteogenic drugs, and on new cross-linked cyclodextrin particles with a high drug loading and sustained drug delivery profile for the treatment of diseases that require prolonged action, such as periodontitis. In conclusion, cyclodextrins are herein demonstrated to act as versatile and multi-action ingredients with a broad range of applications in dentistry. MDPI 2023-08-31 /pmc/articles/PMC10534413/ /pubmed/37765220 http://dx.doi.org/10.3390/pharmaceutics15092251 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Braga, Susana Santos
Cyclodextrins as Multi-Functional Ingredients in Dentistry
title Cyclodextrins as Multi-Functional Ingredients in Dentistry
title_full Cyclodextrins as Multi-Functional Ingredients in Dentistry
title_fullStr Cyclodextrins as Multi-Functional Ingredients in Dentistry
title_full_unstemmed Cyclodextrins as Multi-Functional Ingredients in Dentistry
title_short Cyclodextrins as Multi-Functional Ingredients in Dentistry
title_sort cyclodextrins as multi-functional ingredients in dentistry
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534413/
https://www.ncbi.nlm.nih.gov/pubmed/37765220
http://dx.doi.org/10.3390/pharmaceutics15092251
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