Cargando…
Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Early Pregnancy and Small for Gestational Age in Southern Sweden
Small for gestational age (SGA) is considered an adverse birth outcome. Per- and polyfluoralkyl substances (PFAS) have become increasingly investigated as contributing environmental factors, thus far with inconclusive results. The current study aimed to investigate the hypothesized association betwe...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534445/ https://www.ncbi.nlm.nih.gov/pubmed/37755760 http://dx.doi.org/10.3390/toxics11090750 |
_version_ | 1785112395956355072 |
---|---|
author | Malm, Ellen Vilhelmsson, Andreas Högfeldt, Hannah Deshayes, Isabelle Källén, Karin Hansson, Stefan R. Lindh, Christian H. Rylander, Lars |
author_facet | Malm, Ellen Vilhelmsson, Andreas Högfeldt, Hannah Deshayes, Isabelle Källén, Karin Hansson, Stefan R. Lindh, Christian H. Rylander, Lars |
author_sort | Malm, Ellen |
collection | PubMed |
description | Small for gestational age (SGA) is considered an adverse birth outcome. Per- and polyfluoralkyl substances (PFAS) have become increasingly investigated as contributing environmental factors, thus far with inconclusive results. The current study aimed to investigate the hypothesized association between increased maternal PFAS levels in early pregnancy and an increased risk for SGA birth. This population-based study used data from a sample of children born in Scania, Southern Sweden, between 1995 and 2009. Two groups were compared: cases born with SGA (n = 298) and non-SGA controls (n = 580). The cases consisted of two subgroups: one included women whose children’s growth in late pregnancy was in the lowest quartile, and another included women from the remaining growth quartiles. Corresponding maternal serum samples were collected from a biobank and analyzed for concentrations of four types of PFAS: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) using liquid chromatography–tandem mass spectrometry (LC/MS/MS). The results were combined with information from birth registers and analyzed using Mann–Whitney U-tests and logistic regression—unadjusted as well as adjusted for potential confounders. In conclusion, elevated maternal concentrations of PFAS were not associated with an increased risk of SGA birth. However, significant ORs were observed in a subgroup analysis restricted to women of Nordic origin (unadjusted OR 3.2 and adjusted OR 2.4) for PFHxS. |
format | Online Article Text |
id | pubmed-10534445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105344452023-09-29 Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Early Pregnancy and Small for Gestational Age in Southern Sweden Malm, Ellen Vilhelmsson, Andreas Högfeldt, Hannah Deshayes, Isabelle Källén, Karin Hansson, Stefan R. Lindh, Christian H. Rylander, Lars Toxics Article Small for gestational age (SGA) is considered an adverse birth outcome. Per- and polyfluoralkyl substances (PFAS) have become increasingly investigated as contributing environmental factors, thus far with inconclusive results. The current study aimed to investigate the hypothesized association between increased maternal PFAS levels in early pregnancy and an increased risk for SGA birth. This population-based study used data from a sample of children born in Scania, Southern Sweden, between 1995 and 2009. Two groups were compared: cases born with SGA (n = 298) and non-SGA controls (n = 580). The cases consisted of two subgroups: one included women whose children’s growth in late pregnancy was in the lowest quartile, and another included women from the remaining growth quartiles. Corresponding maternal serum samples were collected from a biobank and analyzed for concentrations of four types of PFAS: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) using liquid chromatography–tandem mass spectrometry (LC/MS/MS). The results were combined with information from birth registers and analyzed using Mann–Whitney U-tests and logistic regression—unadjusted as well as adjusted for potential confounders. In conclusion, elevated maternal concentrations of PFAS were not associated with an increased risk of SGA birth. However, significant ORs were observed in a subgroup analysis restricted to women of Nordic origin (unadjusted OR 3.2 and adjusted OR 2.4) for PFHxS. MDPI 2023-09-04 /pmc/articles/PMC10534445/ /pubmed/37755760 http://dx.doi.org/10.3390/toxics11090750 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Malm, Ellen Vilhelmsson, Andreas Högfeldt, Hannah Deshayes, Isabelle Källén, Karin Hansson, Stefan R. Lindh, Christian H. Rylander, Lars Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Early Pregnancy and Small for Gestational Age in Southern Sweden |
title | Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Early Pregnancy and Small for Gestational Age in Southern Sweden |
title_full | Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Early Pregnancy and Small for Gestational Age in Southern Sweden |
title_fullStr | Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Early Pregnancy and Small for Gestational Age in Southern Sweden |
title_full_unstemmed | Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Early Pregnancy and Small for Gestational Age in Southern Sweden |
title_short | Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances in Early Pregnancy and Small for Gestational Age in Southern Sweden |
title_sort | maternal serum concentrations of per- and polyfluoroalkyl substances in early pregnancy and small for gestational age in southern sweden |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534445/ https://www.ncbi.nlm.nih.gov/pubmed/37755760 http://dx.doi.org/10.3390/toxics11090750 |
work_keys_str_mv | AT malmellen maternalserumconcentrationsofperandpolyfluoroalkylsubstancesinearlypregnancyandsmallforgestationalageinsouthernsweden AT vilhelmssonandreas maternalserumconcentrationsofperandpolyfluoroalkylsubstancesinearlypregnancyandsmallforgestationalageinsouthernsweden AT hogfeldthannah maternalserumconcentrationsofperandpolyfluoroalkylsubstancesinearlypregnancyandsmallforgestationalageinsouthernsweden AT deshayesisabelle maternalserumconcentrationsofperandpolyfluoroalkylsubstancesinearlypregnancyandsmallforgestationalageinsouthernsweden AT kallenkarin maternalserumconcentrationsofperandpolyfluoroalkylsubstancesinearlypregnancyandsmallforgestationalageinsouthernsweden AT hanssonstefanr maternalserumconcentrationsofperandpolyfluoroalkylsubstancesinearlypregnancyandsmallforgestationalageinsouthernsweden AT lindhchristianh maternalserumconcentrationsofperandpolyfluoroalkylsubstancesinearlypregnancyandsmallforgestationalageinsouthernsweden AT rylanderlars maternalserumconcentrationsofperandpolyfluoroalkylsubstancesinearlypregnancyandsmallforgestationalageinsouthernsweden |