Long Non-Coding RNAs as “MYC Facilitators”

In this article, we discuss a class of MYC-interacting lncRNAs (long non-coding RNAs) that share the following criteria: They are direct transcriptional targets of MYC. Their expression is coordinated with the expression of MYC. They are required for sustained MYC-driven cell proliferation, and they...

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Detalles Bibliográficos
Autores principales: García-Caballero, Daniel, Hart, Jonathan R., Vogt, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534484/
https://www.ncbi.nlm.nih.gov/pubmed/37755396
http://dx.doi.org/10.3390/pathophysiology30030030
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author García-Caballero, Daniel
Hart, Jonathan R.
Vogt, Peter K.
author_facet García-Caballero, Daniel
Hart, Jonathan R.
Vogt, Peter K.
author_sort García-Caballero, Daniel
collection PubMed
description In this article, we discuss a class of MYC-interacting lncRNAs (long non-coding RNAs) that share the following criteria: They are direct transcriptional targets of MYC. Their expression is coordinated with the expression of MYC. They are required for sustained MYC-driven cell proliferation, and they are not essential for cell survival. We refer to these lncRNAs as “MYC facilitators” and discuss two representative members of this class of lncRNAs, SNHG17 (small nuclear RNA host gene) and LNROP (long non-coding regulator of POU2F2). We also present a general hypothesis on the role of lncRNAs in MYC-mediated transcriptional regulation.
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spelling pubmed-105344842023-09-29 Long Non-Coding RNAs as “MYC Facilitators” García-Caballero, Daniel Hart, Jonathan R. Vogt, Peter K. Pathophysiology Review In this article, we discuss a class of MYC-interacting lncRNAs (long non-coding RNAs) that share the following criteria: They are direct transcriptional targets of MYC. Their expression is coordinated with the expression of MYC. They are required for sustained MYC-driven cell proliferation, and they are not essential for cell survival. We refer to these lncRNAs as “MYC facilitators” and discuss two representative members of this class of lncRNAs, SNHG17 (small nuclear RNA host gene) and LNROP (long non-coding regulator of POU2F2). We also present a general hypothesis on the role of lncRNAs in MYC-mediated transcriptional regulation. MDPI 2023-09-01 /pmc/articles/PMC10534484/ /pubmed/37755396 http://dx.doi.org/10.3390/pathophysiology30030030 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
García-Caballero, Daniel
Hart, Jonathan R.
Vogt, Peter K.
Long Non-Coding RNAs as “MYC Facilitators”
title Long Non-Coding RNAs as “MYC Facilitators”
title_full Long Non-Coding RNAs as “MYC Facilitators”
title_fullStr Long Non-Coding RNAs as “MYC Facilitators”
title_full_unstemmed Long Non-Coding RNAs as “MYC Facilitators”
title_short Long Non-Coding RNAs as “MYC Facilitators”
title_sort long non-coding rnas as “myc facilitators”
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534484/
https://www.ncbi.nlm.nih.gov/pubmed/37755396
http://dx.doi.org/10.3390/pathophysiology30030030
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