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Cannabis and Other Substance Misuse: Implications and Regulations
Abusing controlled substances, including cannabis and various drugs, can result in severe intoxication and even death. Therefore, a comprehensive postmortem analysis is crucial for understanding the underlying causes of such fatalities. This narrative review discusses the characteristics of commonly...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534492/ https://www.ncbi.nlm.nih.gov/pubmed/37755766 http://dx.doi.org/10.3390/toxics11090756 |
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author | Khairinisa, Miski Aghnia Alfaqeeh, Mohammed Rafif, Syauqi Nawwar Muljono, Fajar Oktavian Colin, Michelle Natasha |
author_facet | Khairinisa, Miski Aghnia Alfaqeeh, Mohammed Rafif, Syauqi Nawwar Muljono, Fajar Oktavian Colin, Michelle Natasha |
author_sort | Khairinisa, Miski Aghnia |
collection | PubMed |
description | Abusing controlled substances, including cannabis and various drugs, can result in severe intoxication and even death. Therefore, a comprehensive postmortem analysis is crucial for understanding the underlying causes of such fatalities. This narrative review discusses the characteristics of commonly abused controlled substances, the methodologies employed in postmortem analysis, lethal dosage levels, mechanisms of toxicity, side effects, and existing regulations. The focus centers on seven prevalent groups of controlled substances, namely cannabis, opioids, amphetamine-type stimulants, cocaine, new psychoactive substances, and hallucinogens. These groups have been linked to an increased risk of fatal overdose. Most substances in these groups exert neurotoxic effects by targeting the central nervous system (CNS). Consequently, strict regulation is essential to mitigate the potential harm posed by these substances. To combat abuse, prescribers must adhere to guidelines to ensure their prescribed medications comply with the outlined regulations. Through an enhanced understanding of controlled substance abuse and its consequences, more effective strategies can be developed to reduce its prevalence and associated mortality. |
format | Online Article Text |
id | pubmed-10534492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105344922023-09-29 Cannabis and Other Substance Misuse: Implications and Regulations Khairinisa, Miski Aghnia Alfaqeeh, Mohammed Rafif, Syauqi Nawwar Muljono, Fajar Oktavian Colin, Michelle Natasha Toxics Review Abusing controlled substances, including cannabis and various drugs, can result in severe intoxication and even death. Therefore, a comprehensive postmortem analysis is crucial for understanding the underlying causes of such fatalities. This narrative review discusses the characteristics of commonly abused controlled substances, the methodologies employed in postmortem analysis, lethal dosage levels, mechanisms of toxicity, side effects, and existing regulations. The focus centers on seven prevalent groups of controlled substances, namely cannabis, opioids, amphetamine-type stimulants, cocaine, new psychoactive substances, and hallucinogens. These groups have been linked to an increased risk of fatal overdose. Most substances in these groups exert neurotoxic effects by targeting the central nervous system (CNS). Consequently, strict regulation is essential to mitigate the potential harm posed by these substances. To combat abuse, prescribers must adhere to guidelines to ensure their prescribed medications comply with the outlined regulations. Through an enhanced understanding of controlled substance abuse and its consequences, more effective strategies can be developed to reduce its prevalence and associated mortality. MDPI 2023-09-06 /pmc/articles/PMC10534492/ /pubmed/37755766 http://dx.doi.org/10.3390/toxics11090756 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Khairinisa, Miski Aghnia Alfaqeeh, Mohammed Rafif, Syauqi Nawwar Muljono, Fajar Oktavian Colin, Michelle Natasha Cannabis and Other Substance Misuse: Implications and Regulations |
title | Cannabis and Other Substance Misuse: Implications and Regulations |
title_full | Cannabis and Other Substance Misuse: Implications and Regulations |
title_fullStr | Cannabis and Other Substance Misuse: Implications and Regulations |
title_full_unstemmed | Cannabis and Other Substance Misuse: Implications and Regulations |
title_short | Cannabis and Other Substance Misuse: Implications and Regulations |
title_sort | cannabis and other substance misuse: implications and regulations |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534492/ https://www.ncbi.nlm.nih.gov/pubmed/37755766 http://dx.doi.org/10.3390/toxics11090756 |
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