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The Endometrial Microbiota: Challenges and Prospects
Contrary to popular belief, we have known for many years that the endometrium is not a sterile environment and is considered to be a low-biomass milieu compared to the vagina. Numerous trials and studies have attempted to establish a valid sampling method and assess its physiological composition, bu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534531/ https://www.ncbi.nlm.nih.gov/pubmed/37763663 http://dx.doi.org/10.3390/medicina59091540 |
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author | Kaluanga Bwanga, Pauline Tremblay-Lemoine, Pierre-Luc Timmermans, Marie Ravet, Stéphanie Munaut, Carine Nisolle, Michelle Henry, Laurie |
author_facet | Kaluanga Bwanga, Pauline Tremblay-Lemoine, Pierre-Luc Timmermans, Marie Ravet, Stéphanie Munaut, Carine Nisolle, Michelle Henry, Laurie |
author_sort | Kaluanga Bwanga, Pauline |
collection | PubMed |
description | Contrary to popular belief, we have known for many years that the endometrium is not a sterile environment and is considered to be a low-biomass milieu compared to the vagina. Numerous trials and studies have attempted to establish a valid sampling method and assess its physiological composition, but no consensus has been reached. Many factors, such as ethnicity, age and inflammation, can influence the microbiome. Moreover, it possesses a higher alpha-diversity and, therefore, contains more diverse bacteria than the vagina. For instance, Lactobacillus has been shown to be a predominant genus in the vaginal microbiome of healthy women. Consequently, even if a majority of scientists postulate that a predominance of Lactobacillus inside the uterus improves reproductive outcomes, vaginal contamination by these bacteria during sampling cannot be ruled out. Certain pathologies, such as chronic endometritis, have been identified as inflammation perpetrators that hinder the embryo implantation process. This pro-inflammatory climate created by dysbiosis of the endometrial microbiota could induce secondary inflammatory mediators via Toll-like receptors, creating an environment conducive to the development of endometriosis and even promoting carcinogenesis. However, studies to this day have focused on small populations. In addition, there is no clearly defined healthy uterine composition yet. At most, only a few taxa have been identified as pathogenic. As sampling and analysis methods become increasingly precise, we can expect the endometrial microbiota to be incorporated into future diagnostic tools and treatments for women’s health. |
format | Online Article Text |
id | pubmed-10534531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105345312023-09-29 The Endometrial Microbiota: Challenges and Prospects Kaluanga Bwanga, Pauline Tremblay-Lemoine, Pierre-Luc Timmermans, Marie Ravet, Stéphanie Munaut, Carine Nisolle, Michelle Henry, Laurie Medicina (Kaunas) Review Contrary to popular belief, we have known for many years that the endometrium is not a sterile environment and is considered to be a low-biomass milieu compared to the vagina. Numerous trials and studies have attempted to establish a valid sampling method and assess its physiological composition, but no consensus has been reached. Many factors, such as ethnicity, age and inflammation, can influence the microbiome. Moreover, it possesses a higher alpha-diversity and, therefore, contains more diverse bacteria than the vagina. For instance, Lactobacillus has been shown to be a predominant genus in the vaginal microbiome of healthy women. Consequently, even if a majority of scientists postulate that a predominance of Lactobacillus inside the uterus improves reproductive outcomes, vaginal contamination by these bacteria during sampling cannot be ruled out. Certain pathologies, such as chronic endometritis, have been identified as inflammation perpetrators that hinder the embryo implantation process. This pro-inflammatory climate created by dysbiosis of the endometrial microbiota could induce secondary inflammatory mediators via Toll-like receptors, creating an environment conducive to the development of endometriosis and even promoting carcinogenesis. However, studies to this day have focused on small populations. In addition, there is no clearly defined healthy uterine composition yet. At most, only a few taxa have been identified as pathogenic. As sampling and analysis methods become increasingly precise, we can expect the endometrial microbiota to be incorporated into future diagnostic tools and treatments for women’s health. MDPI 2023-08-25 /pmc/articles/PMC10534531/ /pubmed/37763663 http://dx.doi.org/10.3390/medicina59091540 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kaluanga Bwanga, Pauline Tremblay-Lemoine, Pierre-Luc Timmermans, Marie Ravet, Stéphanie Munaut, Carine Nisolle, Michelle Henry, Laurie The Endometrial Microbiota: Challenges and Prospects |
title | The Endometrial Microbiota: Challenges and Prospects |
title_full | The Endometrial Microbiota: Challenges and Prospects |
title_fullStr | The Endometrial Microbiota: Challenges and Prospects |
title_full_unstemmed | The Endometrial Microbiota: Challenges and Prospects |
title_short | The Endometrial Microbiota: Challenges and Prospects |
title_sort | endometrial microbiota: challenges and prospects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534531/ https://www.ncbi.nlm.nih.gov/pubmed/37763663 http://dx.doi.org/10.3390/medicina59091540 |
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