Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods

Ochratoxins are the secondary metabolites of Penicillium and Aspergillus, among which ochratoxin A (OTA) is the most toxic molecule. OTA is widely found in food and agricultural products. Due to its severe nephrotoxicity, immunotoxicity, neurotoxicity, and teratogenic mutagenesis, it is essential to...

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Detalles Bibliográficos
Autores principales: Ding, Lijuan, Han, Meihua, Wang, Xiangtao, Guo, Yifei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534725/
https://www.ncbi.nlm.nih.gov/pubmed/37755991
http://dx.doi.org/10.3390/toxins15090565
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author Ding, Lijuan
Han, Meihua
Wang, Xiangtao
Guo, Yifei
author_facet Ding, Lijuan
Han, Meihua
Wang, Xiangtao
Guo, Yifei
author_sort Ding, Lijuan
collection PubMed
description Ochratoxins are the secondary metabolites of Penicillium and Aspergillus, among which ochratoxin A (OTA) is the most toxic molecule. OTA is widely found in food and agricultural products. Due to its severe nephrotoxicity, immunotoxicity, neurotoxicity, and teratogenic mutagenesis, it is essential to develop effective, economical, and environmentally friendly methods for OTA decontamination and detoxification. This review mainly summarizes the application of technology in OTA prevention, removal, and detoxification from physical, chemical, and biological aspects, depending on the properties of OTA, and describes the advantages and disadvantages of each method from an objective perspective. Overall, biological methods have the greatest potential to degrade OTA. This review provides some ideas for searching for new strains and degrading enzymes.
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spelling pubmed-105347252023-09-29 Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods Ding, Lijuan Han, Meihua Wang, Xiangtao Guo, Yifei Toxins (Basel) Review Ochratoxins are the secondary metabolites of Penicillium and Aspergillus, among which ochratoxin A (OTA) is the most toxic molecule. OTA is widely found in food and agricultural products. Due to its severe nephrotoxicity, immunotoxicity, neurotoxicity, and teratogenic mutagenesis, it is essential to develop effective, economical, and environmentally friendly methods for OTA decontamination and detoxification. This review mainly summarizes the application of technology in OTA prevention, removal, and detoxification from physical, chemical, and biological aspects, depending on the properties of OTA, and describes the advantages and disadvantages of each method from an objective perspective. Overall, biological methods have the greatest potential to degrade OTA. This review provides some ideas for searching for new strains and degrading enzymes. MDPI 2023-09-08 /pmc/articles/PMC10534725/ /pubmed/37755991 http://dx.doi.org/10.3390/toxins15090565 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ding, Lijuan
Han, Meihua
Wang, Xiangtao
Guo, Yifei
Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods
title Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods
title_full Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods
title_fullStr Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods
title_full_unstemmed Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods
title_short Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods
title_sort ochratoxin a: overview of prevention, removal, and detoxification methods
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534725/
https://www.ncbi.nlm.nih.gov/pubmed/37755991
http://dx.doi.org/10.3390/toxins15090565
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AT hanmeihua ochratoxinaoverviewofpreventionremovalanddetoxificationmethods
AT wangxiangtao ochratoxinaoverviewofpreventionremovalanddetoxificationmethods
AT guoyifei ochratoxinaoverviewofpreventionremovalanddetoxificationmethods

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