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Comparison of Fused Diffusion-Weighted Imaging Using Unenhanced MRI and Abbreviated Post-Contrast-Enhanced MRI in Patients with Breast Cancer

Background and Objectives: To determine the percentage of breast cancers detectable by fused diffusion-weighted imaging (DWI) using unenhanced magnetic resonance imaging (MRI) and abbreviated post-contrast-enhanced MRI. Materials and Methods: Between October 2016 and October 2017, 194 consecutive wo...

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Autores principales: Lee, Kyeyoung, Jeong, Yeo Jin, Choo, Ki Seok, Nam, Su Bong, Kim, Hyun Yul, Jung, Youn Joo, Lee, Seung Ju, Joo, Ji Hyeon, Kim, Jin You, Kim, Jin Joo, Kim, Jee Yeon, Yun, Mi Sook, Nam, Kyung Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534817/
https://www.ncbi.nlm.nih.gov/pubmed/37763682
http://dx.doi.org/10.3390/medicina59091563
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author Lee, Kyeyoung
Jeong, Yeo Jin
Choo, Ki Seok
Nam, Su Bong
Kim, Hyun Yul
Jung, Youn Joo
Lee, Seung Ju
Joo, Ji Hyeon
Kim, Jin You
Kim, Jin Joo
Kim, Jee Yeon
Yun, Mi Sook
Nam, Kyung Jin
author_facet Lee, Kyeyoung
Jeong, Yeo Jin
Choo, Ki Seok
Nam, Su Bong
Kim, Hyun Yul
Jung, Youn Joo
Lee, Seung Ju
Joo, Ji Hyeon
Kim, Jin You
Kim, Jin Joo
Kim, Jee Yeon
Yun, Mi Sook
Nam, Kyung Jin
author_sort Lee, Kyeyoung
collection PubMed
description Background and Objectives: To determine the percentage of breast cancers detectable by fused diffusion-weighted imaging (DWI) using unenhanced magnetic resonance imaging (MRI) and abbreviated post-contrast-enhanced MRI. Materials and Methods: Between October 2016 and October 2017, 194 consecutive women (mean age, 54.2 years; age range, 28–82 years) with newly diagnosed unilateral breast cancer, who underwent preoperative 3.0 T breast MRI with DWI, were evaluated. Both fused DWI and abbreviated MRI were independently reviewed by two radiologists for the detection of index cancer (which showed the most suspicious findings in both breasts), location, lesion conspicuity, lesion type, and lesion size. Moreover, the relationship between cancer detection and histopathological results of surgical specimens was evaluated. Results: Index cancer detection rates were comparable between fused DWI and abbreviated MRI (radiologist 1: 174/194 [89.7%] vs. 184/194 [94.8%], respectively, p = 0.057; radiologist 2: 174/194 [89.7%] vs. 183/194 [94.3%], respectively, p = 0.092). In both radiologists, abbreviated MRI showed a significantly higher lesion conspicuity than fused DWI (radiologist 1: 9.37 ± 2.24 vs. 8.78 ± 3.03, respectively, p < 0.001; radiologist 2: 9.16 ± 2.32 vs. 8.39 ± 2.93, respectively, p < 0.001). The κ value for the interobserver agreement of index cancer detection was 0.67 on fused DWI and 0.85 on abbreviated MRI. For lesion conspicuity, the intraclass correlation coefficients were 0.72 on fused DWI and 0.82 on abbreviated MRI. Among the histopathological factors, tumor invasiveness was associated with cancer detection on both fused DWI (p = 0.011) and abbreviated MRI (p = 0.004, radiologist 1), lymphovascular invasion on abbreviated MRI (p = 0.032, radiologist 1), and necrosis on fused DWI (p = 0.031, radiologist 2). Conclusions: Index cancer detection was comparable between fused DWI and abbreviated MRI, although abbreviated MRI showed a significantly better lesion conspicuity.
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spelling pubmed-105348172023-09-29 Comparison of Fused Diffusion-Weighted Imaging Using Unenhanced MRI and Abbreviated Post-Contrast-Enhanced MRI in Patients with Breast Cancer Lee, Kyeyoung Jeong, Yeo Jin Choo, Ki Seok Nam, Su Bong Kim, Hyun Yul Jung, Youn Joo Lee, Seung Ju Joo, Ji Hyeon Kim, Jin You Kim, Jin Joo Kim, Jee Yeon Yun, Mi Sook Nam, Kyung Jin Medicina (Kaunas) Article Background and Objectives: To determine the percentage of breast cancers detectable by fused diffusion-weighted imaging (DWI) using unenhanced magnetic resonance imaging (MRI) and abbreviated post-contrast-enhanced MRI. Materials and Methods: Between October 2016 and October 2017, 194 consecutive women (mean age, 54.2 years; age range, 28–82 years) with newly diagnosed unilateral breast cancer, who underwent preoperative 3.0 T breast MRI with DWI, were evaluated. Both fused DWI and abbreviated MRI were independently reviewed by two radiologists for the detection of index cancer (which showed the most suspicious findings in both breasts), location, lesion conspicuity, lesion type, and lesion size. Moreover, the relationship between cancer detection and histopathological results of surgical specimens was evaluated. Results: Index cancer detection rates were comparable between fused DWI and abbreviated MRI (radiologist 1: 174/194 [89.7%] vs. 184/194 [94.8%], respectively, p = 0.057; radiologist 2: 174/194 [89.7%] vs. 183/194 [94.3%], respectively, p = 0.092). In both radiologists, abbreviated MRI showed a significantly higher lesion conspicuity than fused DWI (radiologist 1: 9.37 ± 2.24 vs. 8.78 ± 3.03, respectively, p < 0.001; radiologist 2: 9.16 ± 2.32 vs. 8.39 ± 2.93, respectively, p < 0.001). The κ value for the interobserver agreement of index cancer detection was 0.67 on fused DWI and 0.85 on abbreviated MRI. For lesion conspicuity, the intraclass correlation coefficients were 0.72 on fused DWI and 0.82 on abbreviated MRI. Among the histopathological factors, tumor invasiveness was associated with cancer detection on both fused DWI (p = 0.011) and abbreviated MRI (p = 0.004, radiologist 1), lymphovascular invasion on abbreviated MRI (p = 0.032, radiologist 1), and necrosis on fused DWI (p = 0.031, radiologist 2). Conclusions: Index cancer detection was comparable between fused DWI and abbreviated MRI, although abbreviated MRI showed a significantly better lesion conspicuity. MDPI 2023-08-28 /pmc/articles/PMC10534817/ /pubmed/37763682 http://dx.doi.org/10.3390/medicina59091563 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Kyeyoung
Jeong, Yeo Jin
Choo, Ki Seok
Nam, Su Bong
Kim, Hyun Yul
Jung, Youn Joo
Lee, Seung Ju
Joo, Ji Hyeon
Kim, Jin You
Kim, Jin Joo
Kim, Jee Yeon
Yun, Mi Sook
Nam, Kyung Jin
Comparison of Fused Diffusion-Weighted Imaging Using Unenhanced MRI and Abbreviated Post-Contrast-Enhanced MRI in Patients with Breast Cancer
title Comparison of Fused Diffusion-Weighted Imaging Using Unenhanced MRI and Abbreviated Post-Contrast-Enhanced MRI in Patients with Breast Cancer
title_full Comparison of Fused Diffusion-Weighted Imaging Using Unenhanced MRI and Abbreviated Post-Contrast-Enhanced MRI in Patients with Breast Cancer
title_fullStr Comparison of Fused Diffusion-Weighted Imaging Using Unenhanced MRI and Abbreviated Post-Contrast-Enhanced MRI in Patients with Breast Cancer
title_full_unstemmed Comparison of Fused Diffusion-Weighted Imaging Using Unenhanced MRI and Abbreviated Post-Contrast-Enhanced MRI in Patients with Breast Cancer
title_short Comparison of Fused Diffusion-Weighted Imaging Using Unenhanced MRI and Abbreviated Post-Contrast-Enhanced MRI in Patients with Breast Cancer
title_sort comparison of fused diffusion-weighted imaging using unenhanced mri and abbreviated post-contrast-enhanced mri in patients with breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534817/
https://www.ncbi.nlm.nih.gov/pubmed/37763682
http://dx.doi.org/10.3390/medicina59091563
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