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Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review

Plasmalogens are a unique family of cellular glycerophospholipids that contain a vinyl-ether bond. The synthesis of plasmalogens is initiated in peroxisomes and completed in the endoplasmic reticulum. Plasmalogens are transported to the post-Golgi compartment, including endosomes and plasma membrane...

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Autores principales: Honsho, Masanori, Fujiki, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534842/
https://www.ncbi.nlm.nih.gov/pubmed/37755186
http://dx.doi.org/10.3390/membranes13090764
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author Honsho, Masanori
Fujiki, Yukio
author_facet Honsho, Masanori
Fujiki, Yukio
author_sort Honsho, Masanori
collection PubMed
description Plasmalogens are a unique family of cellular glycerophospholipids that contain a vinyl-ether bond. The synthesis of plasmalogens is initiated in peroxisomes and completed in the endoplasmic reticulum. Plasmalogens are transported to the post-Golgi compartment, including endosomes and plasma membranes, in a manner dependent on ATP, but not vesicular transport. Plasmalogens are preferentially localized in the inner leaflet of the plasma membrane in a manner dependent on P4-type ATPase ATP8B2, that associates with the CDC50 subunit. Plasmalogen biosynthesis is spatiotemporally regulated by a feedback mechanism that senses the amount of plasmalogens in the inner leaflet of the plasma membrane and controls the stability of fatty acyl-CoA reductase 1 (FAR1), the rate-limiting enzyme for plasmalogen biosynthesis. The physiological consequences of such asymmetric localization and homeostasis of plasmalogens are discussed in this review.
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spelling pubmed-105348422023-09-29 Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review Honsho, Masanori Fujiki, Yukio Membranes (Basel) Review Plasmalogens are a unique family of cellular glycerophospholipids that contain a vinyl-ether bond. The synthesis of plasmalogens is initiated in peroxisomes and completed in the endoplasmic reticulum. Plasmalogens are transported to the post-Golgi compartment, including endosomes and plasma membranes, in a manner dependent on ATP, but not vesicular transport. Plasmalogens are preferentially localized in the inner leaflet of the plasma membrane in a manner dependent on P4-type ATPase ATP8B2, that associates with the CDC50 subunit. Plasmalogen biosynthesis is spatiotemporally regulated by a feedback mechanism that senses the amount of plasmalogens in the inner leaflet of the plasma membrane and controls the stability of fatty acyl-CoA reductase 1 (FAR1), the rate-limiting enzyme for plasmalogen biosynthesis. The physiological consequences of such asymmetric localization and homeostasis of plasmalogens are discussed in this review. MDPI 2023-08-29 /pmc/articles/PMC10534842/ /pubmed/37755186 http://dx.doi.org/10.3390/membranes13090764 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Honsho, Masanori
Fujiki, Yukio
Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review
title Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review
title_full Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review
title_fullStr Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review
title_full_unstemmed Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review
title_short Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review
title_sort asymmetric distribution of plasmalogens and their roles—a mini review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534842/
https://www.ncbi.nlm.nih.gov/pubmed/37755186
http://dx.doi.org/10.3390/membranes13090764
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