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Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review
Plasmalogens are a unique family of cellular glycerophospholipids that contain a vinyl-ether bond. The synthesis of plasmalogens is initiated in peroxisomes and completed in the endoplasmic reticulum. Plasmalogens are transported to the post-Golgi compartment, including endosomes and plasma membrane...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534842/ https://www.ncbi.nlm.nih.gov/pubmed/37755186 http://dx.doi.org/10.3390/membranes13090764 |
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author | Honsho, Masanori Fujiki, Yukio |
author_facet | Honsho, Masanori Fujiki, Yukio |
author_sort | Honsho, Masanori |
collection | PubMed |
description | Plasmalogens are a unique family of cellular glycerophospholipids that contain a vinyl-ether bond. The synthesis of plasmalogens is initiated in peroxisomes and completed in the endoplasmic reticulum. Plasmalogens are transported to the post-Golgi compartment, including endosomes and plasma membranes, in a manner dependent on ATP, but not vesicular transport. Plasmalogens are preferentially localized in the inner leaflet of the plasma membrane in a manner dependent on P4-type ATPase ATP8B2, that associates with the CDC50 subunit. Plasmalogen biosynthesis is spatiotemporally regulated by a feedback mechanism that senses the amount of plasmalogens in the inner leaflet of the plasma membrane and controls the stability of fatty acyl-CoA reductase 1 (FAR1), the rate-limiting enzyme for plasmalogen biosynthesis. The physiological consequences of such asymmetric localization and homeostasis of plasmalogens are discussed in this review. |
format | Online Article Text |
id | pubmed-10534842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105348422023-09-29 Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review Honsho, Masanori Fujiki, Yukio Membranes (Basel) Review Plasmalogens are a unique family of cellular glycerophospholipids that contain a vinyl-ether bond. The synthesis of plasmalogens is initiated in peroxisomes and completed in the endoplasmic reticulum. Plasmalogens are transported to the post-Golgi compartment, including endosomes and plasma membranes, in a manner dependent on ATP, but not vesicular transport. Plasmalogens are preferentially localized in the inner leaflet of the plasma membrane in a manner dependent on P4-type ATPase ATP8B2, that associates with the CDC50 subunit. Plasmalogen biosynthesis is spatiotemporally regulated by a feedback mechanism that senses the amount of plasmalogens in the inner leaflet of the plasma membrane and controls the stability of fatty acyl-CoA reductase 1 (FAR1), the rate-limiting enzyme for plasmalogen biosynthesis. The physiological consequences of such asymmetric localization and homeostasis of plasmalogens are discussed in this review. MDPI 2023-08-29 /pmc/articles/PMC10534842/ /pubmed/37755186 http://dx.doi.org/10.3390/membranes13090764 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Honsho, Masanori Fujiki, Yukio Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review |
title | Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review |
title_full | Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review |
title_fullStr | Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review |
title_full_unstemmed | Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review |
title_short | Asymmetric Distribution of Plasmalogens and Their Roles—A Mini Review |
title_sort | asymmetric distribution of plasmalogens and their roles—a mini review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534842/ https://www.ncbi.nlm.nih.gov/pubmed/37755186 http://dx.doi.org/10.3390/membranes13090764 |
work_keys_str_mv | AT honshomasanori asymmetricdistributionofplasmalogensandtheirrolesaminireview AT fujikiyukio asymmetricdistributionofplasmalogensandtheirrolesaminireview |