Topical Micro-Emulsion of 5-Fluorouracil by a Twin Screw Processor-Based Novel Continuous Manufacturing Process for the Treatment of Skin Cancer: Preparation and In Vitro and In Vivo Evaluations

5-Fluorouracil (5-FU), a BCS class III drug, has low oral bioavailability and is cytotoxic in nature causing severe systemic side effects when administered through the intravenous route. Topical drug delivery could potentially mitigate the systemic side-effects. Microemulsions (MEs) would be an apt...

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Detalles Bibliográficos
Autores principales: Nikam, Ajinkya Nitin, Jacob, Angela, Raychaudhuri, Ruchira, Fernandes, Gasper, Pandey, Abhijeet, Rao, Vinay, Ahmad, Sheikh F., Pannala, Ananth S., Mutalik, Srinivas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534867/
https://www.ncbi.nlm.nih.gov/pubmed/37765146
http://dx.doi.org/10.3390/pharmaceutics15092175

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