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Outcomes of Gestational Trophoblastic Disease Management: A Single Centre Review
Background and Objectives: Gestational trophoblastic disease (GTD) is a group of pregnancy-related malignant and premalignant diseases. The aim of this study was to assess the prognostic value of clinical characteristics to predict treatment outcomes in women with GTD. Materials and Methods: In this...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534929/ https://www.ncbi.nlm.nih.gov/pubmed/37763750 http://dx.doi.org/10.3390/medicina59091632 |
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author | Malovrh, Eva Pavla Lukinovič, Nuša Sobočan, Monika Knez, Jure |
author_facet | Malovrh, Eva Pavla Lukinovič, Nuša Sobočan, Monika Knez, Jure |
author_sort | Malovrh, Eva Pavla |
collection | PubMed |
description | Background and Objectives: Gestational trophoblastic disease (GTD) is a group of pregnancy-related malignant and premalignant diseases. The aim of this study was to assess the prognostic value of clinical characteristics to predict treatment outcomes in women with GTD. Materials and Methods: In this retrospective study, 34 patients treated for GTD at the Division of Gynaecology and Perinatology, University Medical Centre Maribor, between 2008 and 2022 were identified. Clinical and pathological characteristics were obtained by analysing patient data records. Results: Within the cohort of 34 patients with GTD, 29 patients (85.3%) had a partial hydatidiform mole (HM) and five patients545 (14.7%) had a complete HM. Two patients with a complete HM developed a postmolar gestational trophoblastic neoplasia (GTN), which represents 5.8% of all cases. Conclusions: GTD is a rare disease that is frequently asymptomatic. The subsequent consequences of GTD, which can lead to malignant transformation, as well life-threatening disease complications, warrant training for early recognition of HMs and timely treatment and surveillance. |
format | Online Article Text |
id | pubmed-10534929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105349292023-09-29 Outcomes of Gestational Trophoblastic Disease Management: A Single Centre Review Malovrh, Eva Pavla Lukinovič, Nuša Sobočan, Monika Knez, Jure Medicina (Kaunas) Article Background and Objectives: Gestational trophoblastic disease (GTD) is a group of pregnancy-related malignant and premalignant diseases. The aim of this study was to assess the prognostic value of clinical characteristics to predict treatment outcomes in women with GTD. Materials and Methods: In this retrospective study, 34 patients treated for GTD at the Division of Gynaecology and Perinatology, University Medical Centre Maribor, between 2008 and 2022 were identified. Clinical and pathological characteristics were obtained by analysing patient data records. Results: Within the cohort of 34 patients with GTD, 29 patients (85.3%) had a partial hydatidiform mole (HM) and five patients545 (14.7%) had a complete HM. Two patients with a complete HM developed a postmolar gestational trophoblastic neoplasia (GTN), which represents 5.8% of all cases. Conclusions: GTD is a rare disease that is frequently asymptomatic. The subsequent consequences of GTD, which can lead to malignant transformation, as well life-threatening disease complications, warrant training for early recognition of HMs and timely treatment and surveillance. MDPI 2023-09-08 /pmc/articles/PMC10534929/ /pubmed/37763750 http://dx.doi.org/10.3390/medicina59091632 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Malovrh, Eva Pavla Lukinovič, Nuša Sobočan, Monika Knez, Jure Outcomes of Gestational Trophoblastic Disease Management: A Single Centre Review |
title | Outcomes of Gestational Trophoblastic Disease Management: A Single Centre Review |
title_full | Outcomes of Gestational Trophoblastic Disease Management: A Single Centre Review |
title_fullStr | Outcomes of Gestational Trophoblastic Disease Management: A Single Centre Review |
title_full_unstemmed | Outcomes of Gestational Trophoblastic Disease Management: A Single Centre Review |
title_short | Outcomes of Gestational Trophoblastic Disease Management: A Single Centre Review |
title_sort | outcomes of gestational trophoblastic disease management: a single centre review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10534929/ https://www.ncbi.nlm.nih.gov/pubmed/37763750 http://dx.doi.org/10.3390/medicina59091632 |
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