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Disseminated Mycobacterium genavense Infection Mimicking Sarcoidosis: A Case Report and Review of Literature on Japanese Patients
Sarcoidosis is a systemic inflammatory disease characterized by noncaseating epithelioid cell granulomas. However, certain infections can exhibit similar histological findings. We present a case of a 69-year-old man who was initially diagnosed with sarcoidosis and later was confirmed, through 16S rR...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535052/ https://www.ncbi.nlm.nih.gov/pubmed/37763989 http://dx.doi.org/10.3390/microorganisms11092145 |
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author | Ogata, Ryo Kido, Takashi Takeda, Kazuaki Nemoto, Kazuki Heima, Riko Takao, Mami Miyashita, Ritsuko Ozasa, Mutsumi Tokito, Takatomo Okuno, Daisuke Ito, Yuya Yura, Hirokazu Koga, Tomohiro Hashimoto, Kunio Takemoto, Shinnosuke Takazono, Takahiro Ishimoto, Hiroshi Sakamoto, Noriho Fukuda, Kazumasa Sasaki, Yuka Obase, Yasushi Ishimatsu, Yuji Yatera, Kazuhiro Izumikawa, Koichi Mukae, Hiroshi |
author_facet | Ogata, Ryo Kido, Takashi Takeda, Kazuaki Nemoto, Kazuki Heima, Riko Takao, Mami Miyashita, Ritsuko Ozasa, Mutsumi Tokito, Takatomo Okuno, Daisuke Ito, Yuya Yura, Hirokazu Koga, Tomohiro Hashimoto, Kunio Takemoto, Shinnosuke Takazono, Takahiro Ishimoto, Hiroshi Sakamoto, Noriho Fukuda, Kazumasa Sasaki, Yuka Obase, Yasushi Ishimatsu, Yuji Yatera, Kazuhiro Izumikawa, Koichi Mukae, Hiroshi |
author_sort | Ogata, Ryo |
collection | PubMed |
description | Sarcoidosis is a systemic inflammatory disease characterized by noncaseating epithelioid cell granulomas. However, certain infections can exhibit similar histological findings. We present a case of a 69-year-old man who was initially diagnosed with sarcoidosis and later was confirmed, through 16S rRNA sequencing, to have disseminated Mycobacterium genavense infection. Acid-fast bacteria were detected in the bone marrow biopsy using Ziehl–Neelsen staining, but routine clinical tests did not provide a definitive diagnosis. The patient tested negative for HIV, anti-interferon-gamma antibodies, and genetic immunodeficiency disorders. He was treated with multiple drugs, including aminoglycosides and macrolides, but showed no improvement in fever and pancytopenia. However, these clinical signs responded favorably to steroid therapy. We reviewed 17 Japanese cases of M. genavense infection. All cases were in males; 7/17 (41%) were HIV-negative; and 12/17 (71%) had a decreased CD4 count. Genetic analysis confirmed M. genavense isolation, and macrolides were used universally. Mycobacterium genavense infection is challenging to identify and mimics other systemic inflammatory diseases such as sarcoidosis. There are no standard treatment protocols. Our case report and Japanese case review contribute to understanding this rare disease. |
format | Online Article Text |
id | pubmed-10535052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105350522023-09-29 Disseminated Mycobacterium genavense Infection Mimicking Sarcoidosis: A Case Report and Review of Literature on Japanese Patients Ogata, Ryo Kido, Takashi Takeda, Kazuaki Nemoto, Kazuki Heima, Riko Takao, Mami Miyashita, Ritsuko Ozasa, Mutsumi Tokito, Takatomo Okuno, Daisuke Ito, Yuya Yura, Hirokazu Koga, Tomohiro Hashimoto, Kunio Takemoto, Shinnosuke Takazono, Takahiro Ishimoto, Hiroshi Sakamoto, Noriho Fukuda, Kazumasa Sasaki, Yuka Obase, Yasushi Ishimatsu, Yuji Yatera, Kazuhiro Izumikawa, Koichi Mukae, Hiroshi Microorganisms Case Report Sarcoidosis is a systemic inflammatory disease characterized by noncaseating epithelioid cell granulomas. However, certain infections can exhibit similar histological findings. We present a case of a 69-year-old man who was initially diagnosed with sarcoidosis and later was confirmed, through 16S rRNA sequencing, to have disseminated Mycobacterium genavense infection. Acid-fast bacteria were detected in the bone marrow biopsy using Ziehl–Neelsen staining, but routine clinical tests did not provide a definitive diagnosis. The patient tested negative for HIV, anti-interferon-gamma antibodies, and genetic immunodeficiency disorders. He was treated with multiple drugs, including aminoglycosides and macrolides, but showed no improvement in fever and pancytopenia. However, these clinical signs responded favorably to steroid therapy. We reviewed 17 Japanese cases of M. genavense infection. All cases were in males; 7/17 (41%) were HIV-negative; and 12/17 (71%) had a decreased CD4 count. Genetic analysis confirmed M. genavense isolation, and macrolides were used universally. Mycobacterium genavense infection is challenging to identify and mimics other systemic inflammatory diseases such as sarcoidosis. There are no standard treatment protocols. Our case report and Japanese case review contribute to understanding this rare disease. MDPI 2023-08-24 /pmc/articles/PMC10535052/ /pubmed/37763989 http://dx.doi.org/10.3390/microorganisms11092145 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Ogata, Ryo Kido, Takashi Takeda, Kazuaki Nemoto, Kazuki Heima, Riko Takao, Mami Miyashita, Ritsuko Ozasa, Mutsumi Tokito, Takatomo Okuno, Daisuke Ito, Yuya Yura, Hirokazu Koga, Tomohiro Hashimoto, Kunio Takemoto, Shinnosuke Takazono, Takahiro Ishimoto, Hiroshi Sakamoto, Noriho Fukuda, Kazumasa Sasaki, Yuka Obase, Yasushi Ishimatsu, Yuji Yatera, Kazuhiro Izumikawa, Koichi Mukae, Hiroshi Disseminated Mycobacterium genavense Infection Mimicking Sarcoidosis: A Case Report and Review of Literature on Japanese Patients |
title | Disseminated Mycobacterium genavense Infection Mimicking Sarcoidosis: A Case Report and Review of Literature on Japanese Patients |
title_full | Disseminated Mycobacterium genavense Infection Mimicking Sarcoidosis: A Case Report and Review of Literature on Japanese Patients |
title_fullStr | Disseminated Mycobacterium genavense Infection Mimicking Sarcoidosis: A Case Report and Review of Literature on Japanese Patients |
title_full_unstemmed | Disseminated Mycobacterium genavense Infection Mimicking Sarcoidosis: A Case Report and Review of Literature on Japanese Patients |
title_short | Disseminated Mycobacterium genavense Infection Mimicking Sarcoidosis: A Case Report and Review of Literature on Japanese Patients |
title_sort | disseminated mycobacterium genavense infection mimicking sarcoidosis: a case report and review of literature on japanese patients |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535052/ https://www.ncbi.nlm.nih.gov/pubmed/37763989 http://dx.doi.org/10.3390/microorganisms11092145 |
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