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Conjugation with Tris Decreases the Risk of Ketoprofen-Induced Mucosal Damage and Reduces Inflammation-Associated Methane Production in a Rat Model of Colitis

We have designed a new compound from the non-steroidal anti-inflammatory drug (NSAID) ketoprofen (Ket) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (Tris) precursors, with the aim to reduce the gastrointestinal (GI) side effects of NSAID therapies. We investigated mucosal reactions in a standard ra...

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Detalles Bibliográficos
Autores principales:	Ugocsai, Melinda, Bársony, Anett, Varga, Réka Anna, Gajda, Ámos, Vida, Noémi, Lajkó, Norbert, Rónaszéki, Benedek, Tóth, Gábor, Boros, Mihály, Érces, Dániel, Varga, Gabriella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535093/ https://www.ncbi.nlm.nih.gov/pubmed/37765297 http://dx.doi.org/10.3390/pharmaceutics15092329

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