Assigning function to active site residues of Schistosoma mansoni thioredoxin/glutathione reductase from analysis of transient state reductive half-reactions with variant forms of the enzyme

Thioredoxin/glutathione reductase (TGR) from the platyhelminthic parasitic worms has recently been identified as a drug target for the treatment of schistosomiasis. Schistosomes lack catalase, and so are heavily reliant on the regeneration of reduced thioredoxin (Trx) and glutathione (GSH) to reduce...

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Detalles Bibliográficos
Autores principales: Smith, Madison M., Moran, Graham R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535113/
https://www.ncbi.nlm.nih.gov/pubmed/37780207
http://dx.doi.org/10.3389/fmolb.2023.1258333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535113/
https://www.ncbi.nlm.nih.gov/pubmed/37780207
http://dx.doi.org/10.3389/fmolb.2023.1258333

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