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Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives
Oxidative stress and hyperlipidemia are important factors for the initiation and progression of various cell degenerative pathological conditions, including cardiovascular and neurological diseases. A series of cinnamic acid-derived acids, such as ferulic acid, sinapic acid, 3,4-dimethoxycinnamic ac...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535275/ https://www.ncbi.nlm.nih.gov/pubmed/37764507 http://dx.doi.org/10.3390/molecules28186732 |
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author | Nouni, Christina Theodosis-Nobelos, Panagiotis Rekka, Eleni A. |
author_facet | Nouni, Christina Theodosis-Nobelos, Panagiotis Rekka, Eleni A. |
author_sort | Nouni, Christina |
collection | PubMed |
description | Oxidative stress and hyperlipidemia are important factors for the initiation and progression of various cell degenerative pathological conditions, including cardiovascular and neurological diseases. A series of cinnamic acid-derived acids, such as ferulic acid, sinapic acid, 3,4-dimethoxycinnamic acid, p-coumaric acid, and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid, were esterified or amidated with various moieties, bearing different biological activities, and evaluated. The antioxidant and radical scavenging abilities of the compounds via inhibition of rat hepatic microsomal membrane lipid peroxidation, as well as their interaction with the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH), were assessed. Further, their hypolipidemic activity in vivo was tested. The majority of the obtained compounds demonstrated considerable radical scavenging and antioxidant action, with a parallel decrease in Triton-induced hyperlipidemia in rats. The (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid derivative with morpholine and 4-methylpiperidine (compounds 4 and 13, respectively) significantly decreased triglycerides and total cholesterol in the plasma of hyperlipidemic rats, with an antioxidant capacity similar to that of the antioxidant Trolox. The compounds were designed to exhibit antioxidant and hypolipidemic pharmacological actions, and this succeeded for the majority of them. Thus, such agents may be of interest in conditions and diseases implicating oxidative stress and dyslipidemia. |
format | Online Article Text |
id | pubmed-10535275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105352752023-09-29 Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives Nouni, Christina Theodosis-Nobelos, Panagiotis Rekka, Eleni A. Molecules Article Oxidative stress and hyperlipidemia are important factors for the initiation and progression of various cell degenerative pathological conditions, including cardiovascular and neurological diseases. A series of cinnamic acid-derived acids, such as ferulic acid, sinapic acid, 3,4-dimethoxycinnamic acid, p-coumaric acid, and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid, were esterified or amidated with various moieties, bearing different biological activities, and evaluated. The antioxidant and radical scavenging abilities of the compounds via inhibition of rat hepatic microsomal membrane lipid peroxidation, as well as their interaction with the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH), were assessed. Further, their hypolipidemic activity in vivo was tested. The majority of the obtained compounds demonstrated considerable radical scavenging and antioxidant action, with a parallel decrease in Triton-induced hyperlipidemia in rats. The (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid derivative with morpholine and 4-methylpiperidine (compounds 4 and 13, respectively) significantly decreased triglycerides and total cholesterol in the plasma of hyperlipidemic rats, with an antioxidant capacity similar to that of the antioxidant Trolox. The compounds were designed to exhibit antioxidant and hypolipidemic pharmacological actions, and this succeeded for the majority of them. Thus, such agents may be of interest in conditions and diseases implicating oxidative stress and dyslipidemia. MDPI 2023-09-21 /pmc/articles/PMC10535275/ /pubmed/37764507 http://dx.doi.org/10.3390/molecules28186732 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nouni, Christina Theodosis-Nobelos, Panagiotis Rekka, Eleni A. Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives |
title | Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives |
title_full | Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives |
title_fullStr | Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives |
title_full_unstemmed | Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives |
title_short | Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives |
title_sort | antioxidant and hypolipidemic activities of cinnamic acid derivatives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535275/ https://www.ncbi.nlm.nih.gov/pubmed/37764507 http://dx.doi.org/10.3390/molecules28186732 |
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