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A Novel Magnetic Resonance Imaging-Based Radiomics and Clinical Predictive Model for the Regrowth of Postoperative Residual Tumor in Non-Functioning Pituitary Neuroendocrine Tumor

Background and Objectives: To develop a novel magnetic resonance imaging (MRI)-based radiomics–clinical risk stratification model to predict the regrowth of postoperative residual tumors in patients with non-functioning pituitary neuroendocrine tumors (NF-PitNETs). Materials and Methods: We retrospe...

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Detalles Bibliográficos
Autores principales: Shen, Chaodong, Liu, Xiaoyan, Jin, Jinghao, Han, Cheng, Wu, Lihao, Wu, Zerui, Su, Zhipeng, Chen, Xiaofang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535289/
https://www.ncbi.nlm.nih.gov/pubmed/37763643
http://dx.doi.org/10.3390/medicina59091525
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author Shen, Chaodong
Liu, Xiaoyan
Jin, Jinghao
Han, Cheng
Wu, Lihao
Wu, Zerui
Su, Zhipeng
Chen, Xiaofang
author_facet Shen, Chaodong
Liu, Xiaoyan
Jin, Jinghao
Han, Cheng
Wu, Lihao
Wu, Zerui
Su, Zhipeng
Chen, Xiaofang
author_sort Shen, Chaodong
collection PubMed
description Background and Objectives: To develop a novel magnetic resonance imaging (MRI)-based radiomics–clinical risk stratification model to predict the regrowth of postoperative residual tumors in patients with non-functioning pituitary neuroendocrine tumors (NF-PitNETs). Materials and Methods: We retrospectively enrolled 114 patients diagnosed as NF-PitNET with postoperative residual tumors after the first operation, and the diameter of the tumors was greater than 10 mm. Univariate and multivariate analyses were conducted to identify independent clinical risk factors. We identified the optimal sequence to generate an appropriate radiomic score (Rscore) that combined pre- and postoperative radiomic features. Three models were established by logistic regression analysis that combined clinical risk factors and radiomic features (Model 1), single clinical risk factors (Model 2) and single radiomic features (Model 3). The models’ predictive performances were evaluated using receiver operator characteristic (ROC) curve analysis and area under curve (AUC) values. A nomogram was developed and evaluated using decision curve analysis. Results: Knosp classification and preoperative tumor volume doubling time (TVDT) were high-risk factors (p < 0.05) with odds ratios (ORs) of 2.255 and 0.173. T1WI&T1CE had a higher AUC value (0.954) and generated an Rscore. Ultimately, the AUC of Model 1 {0.929 [95% Confidence interval (CI), 0.865–0.993]} was superior to Model 2 [0.811 (95% CI, 0.704–0.918)] and Model 3 [0.844 (95% CI, 0.748–0.941)] in the training set, which were 0.882 (95% CI, 0.735–1.000), 0.834 (95% CI, 0.676–0.992) and 0.763 (95% CI, 0.569–0.958) in the test set, respectively. Conclusions: We trained a novel radiomics–clinical predictive model for identifying patients with NF-PitNETs at increased risk of postoperative residual tumor regrowth. This model may help optimize individualized and stratified clinical treatment decisions.
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spelling pubmed-105352892023-09-29 A Novel Magnetic Resonance Imaging-Based Radiomics and Clinical Predictive Model for the Regrowth of Postoperative Residual Tumor in Non-Functioning Pituitary Neuroendocrine Tumor Shen, Chaodong Liu, Xiaoyan Jin, Jinghao Han, Cheng Wu, Lihao Wu, Zerui Su, Zhipeng Chen, Xiaofang Medicina (Kaunas) Article Background and Objectives: To develop a novel magnetic resonance imaging (MRI)-based radiomics–clinical risk stratification model to predict the regrowth of postoperative residual tumors in patients with non-functioning pituitary neuroendocrine tumors (NF-PitNETs). Materials and Methods: We retrospectively enrolled 114 patients diagnosed as NF-PitNET with postoperative residual tumors after the first operation, and the diameter of the tumors was greater than 10 mm. Univariate and multivariate analyses were conducted to identify independent clinical risk factors. We identified the optimal sequence to generate an appropriate radiomic score (Rscore) that combined pre- and postoperative radiomic features. Three models were established by logistic regression analysis that combined clinical risk factors and radiomic features (Model 1), single clinical risk factors (Model 2) and single radiomic features (Model 3). The models’ predictive performances were evaluated using receiver operator characteristic (ROC) curve analysis and area under curve (AUC) values. A nomogram was developed and evaluated using decision curve analysis. Results: Knosp classification and preoperative tumor volume doubling time (TVDT) were high-risk factors (p < 0.05) with odds ratios (ORs) of 2.255 and 0.173. T1WI&T1CE had a higher AUC value (0.954) and generated an Rscore. Ultimately, the AUC of Model 1 {0.929 [95% Confidence interval (CI), 0.865–0.993]} was superior to Model 2 [0.811 (95% CI, 0.704–0.918)] and Model 3 [0.844 (95% CI, 0.748–0.941)] in the training set, which were 0.882 (95% CI, 0.735–1.000), 0.834 (95% CI, 0.676–0.992) and 0.763 (95% CI, 0.569–0.958) in the test set, respectively. Conclusions: We trained a novel radiomics–clinical predictive model for identifying patients with NF-PitNETs at increased risk of postoperative residual tumor regrowth. This model may help optimize individualized and stratified clinical treatment decisions. MDPI 2023-08-23 /pmc/articles/PMC10535289/ /pubmed/37763643 http://dx.doi.org/10.3390/medicina59091525 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shen, Chaodong
Liu, Xiaoyan
Jin, Jinghao
Han, Cheng
Wu, Lihao
Wu, Zerui
Su, Zhipeng
Chen, Xiaofang
A Novel Magnetic Resonance Imaging-Based Radiomics and Clinical Predictive Model for the Regrowth of Postoperative Residual Tumor in Non-Functioning Pituitary Neuroendocrine Tumor
title A Novel Magnetic Resonance Imaging-Based Radiomics and Clinical Predictive Model for the Regrowth of Postoperative Residual Tumor in Non-Functioning Pituitary Neuroendocrine Tumor
title_full A Novel Magnetic Resonance Imaging-Based Radiomics and Clinical Predictive Model for the Regrowth of Postoperative Residual Tumor in Non-Functioning Pituitary Neuroendocrine Tumor
title_fullStr A Novel Magnetic Resonance Imaging-Based Radiomics and Clinical Predictive Model for the Regrowth of Postoperative Residual Tumor in Non-Functioning Pituitary Neuroendocrine Tumor
title_full_unstemmed A Novel Magnetic Resonance Imaging-Based Radiomics and Clinical Predictive Model for the Regrowth of Postoperative Residual Tumor in Non-Functioning Pituitary Neuroendocrine Tumor
title_short A Novel Magnetic Resonance Imaging-Based Radiomics and Clinical Predictive Model for the Regrowth of Postoperative Residual Tumor in Non-Functioning Pituitary Neuroendocrine Tumor
title_sort novel magnetic resonance imaging-based radiomics and clinical predictive model for the regrowth of postoperative residual tumor in non-functioning pituitary neuroendocrine tumor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535289/
https://www.ncbi.nlm.nih.gov/pubmed/37763643
http://dx.doi.org/10.3390/medicina59091525
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