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Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy
As a metabolic disorder, obesity can cause secondary kidney damage, which is called obesity-related glomerulopathy (ORG). As the incidence of obesity increases worldwide, so does the incidence of end-stage renal disease (ESRD) caused by ORGs. However, there is still a lack of effective strategies to...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535317/ https://www.ncbi.nlm.nih.gov/pubmed/37765062 http://dx.doi.org/10.3390/ph16091256 |
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author | Ye, Muyao Yang, Ming Dai, Wenni Li, Hao Zhou, Xun Chen, Yinyin He, Liyu |
author_facet | Ye, Muyao Yang, Ming Dai, Wenni Li, Hao Zhou, Xun Chen, Yinyin He, Liyu |
author_sort | Ye, Muyao |
collection | PubMed |
description | As a metabolic disorder, obesity can cause secondary kidney damage, which is called obesity-related glomerulopathy (ORG). As the incidence of obesity increases worldwide, so does the incidence of end-stage renal disease (ESRD) caused by ORGs. However, there is still a lack of effective strategies to prevent and delay the occurrence and development of ORG. Therefore, a deeper understanding and elaboration of the pathogenesis of ORG is conducive to the development of therapeutic drugs for ORG. Here, we review the characteristics of pathological lesions of ORG and describe the roles of lipid metabolism disorders and mitochondrial oxidative stress in the development of ORG. Finally, we summarize the current available drugs or compounds for the treatment of ORG and suggested that ameliorating renal lipid metabolism and mitochondrial function may be potential therapeutic targets for ORG. |
format | Online Article Text |
id | pubmed-10535317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105353172023-09-29 Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy Ye, Muyao Yang, Ming Dai, Wenni Li, Hao Zhou, Xun Chen, Yinyin He, Liyu Pharmaceuticals (Basel) Review As a metabolic disorder, obesity can cause secondary kidney damage, which is called obesity-related glomerulopathy (ORG). As the incidence of obesity increases worldwide, so does the incidence of end-stage renal disease (ESRD) caused by ORGs. However, there is still a lack of effective strategies to prevent and delay the occurrence and development of ORG. Therefore, a deeper understanding and elaboration of the pathogenesis of ORG is conducive to the development of therapeutic drugs for ORG. Here, we review the characteristics of pathological lesions of ORG and describe the roles of lipid metabolism disorders and mitochondrial oxidative stress in the development of ORG. Finally, we summarize the current available drugs or compounds for the treatment of ORG and suggested that ameliorating renal lipid metabolism and mitochondrial function may be potential therapeutic targets for ORG. MDPI 2023-09-05 /pmc/articles/PMC10535317/ /pubmed/37765062 http://dx.doi.org/10.3390/ph16091256 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ye, Muyao Yang, Ming Dai, Wenni Li, Hao Zhou, Xun Chen, Yinyin He, Liyu Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy |
title | Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy |
title_full | Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy |
title_fullStr | Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy |
title_full_unstemmed | Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy |
title_short | Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy |
title_sort | targeting renal proximal tubule cells in obesity-related glomerulopathy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535317/ https://www.ncbi.nlm.nih.gov/pubmed/37765062 http://dx.doi.org/10.3390/ph16091256 |
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