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The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances

The development of novel antimicrobial agents to replace antibiotics has become urgent due to the emergence of multidrug-resistant microorganisms. Antimicrobial peptides (AMPs), widely distributed in all kingdoms of life, present strong antimicrobial activity against a variety of bacteria, fungi, pa...

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Autores principales: Li, Hanxiao, Niu, Junhui, Wang, Xiaoli, Niu, Mingfu, Liao, Chengshui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535326/
https://www.ncbi.nlm.nih.gov/pubmed/37765247
http://dx.doi.org/10.3390/pharmaceutics15092278
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author Li, Hanxiao
Niu, Junhui
Wang, Xiaoli
Niu, Mingfu
Liao, Chengshui
author_facet Li, Hanxiao
Niu, Junhui
Wang, Xiaoli
Niu, Mingfu
Liao, Chengshui
author_sort Li, Hanxiao
collection PubMed
description The development of novel antimicrobial agents to replace antibiotics has become urgent due to the emergence of multidrug-resistant microorganisms. Antimicrobial peptides (AMPs), widely distributed in all kingdoms of life, present strong antimicrobial activity against a variety of bacteria, fungi, parasites, and viruses. The potential of AMPs as new alternatives to antibiotics has gradually attracted considerable interest. In addition, AMPs exhibit strong anticancer potential as well as anti-inflammatory and immunomodulatory activity. Many studies have provided evidence that AMPs can recruit and activate immune cells, controlling inflammation. This review highlights the scientific literature focusing on evidence for the anti-inflammatory mechanisms of different AMPs in immune cells, including macrophages, monocytes, lymphocytes, mast cells, dendritic cells, neutrophils, and eosinophils. A variety of immunomodulatory characteristics, including the abilities to activate and differentiate immune cells, change the content and expression of inflammatory mediators, and regulate specific cellular functions and inflammation-related signaling pathways, are summarized and discussed in detail. This comprehensive review contributes to a better understanding of the role of AMPs in the regulation of the immune system and provides a reference for the use of AMPs as novel anti-inflammatory drugs for the treatment of various inflammatory diseases.
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spelling pubmed-105353262023-09-29 The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances Li, Hanxiao Niu, Junhui Wang, Xiaoli Niu, Mingfu Liao, Chengshui Pharmaceutics Review The development of novel antimicrobial agents to replace antibiotics has become urgent due to the emergence of multidrug-resistant microorganisms. Antimicrobial peptides (AMPs), widely distributed in all kingdoms of life, present strong antimicrobial activity against a variety of bacteria, fungi, parasites, and viruses. The potential of AMPs as new alternatives to antibiotics has gradually attracted considerable interest. In addition, AMPs exhibit strong anticancer potential as well as anti-inflammatory and immunomodulatory activity. Many studies have provided evidence that AMPs can recruit and activate immune cells, controlling inflammation. This review highlights the scientific literature focusing on evidence for the anti-inflammatory mechanisms of different AMPs in immune cells, including macrophages, monocytes, lymphocytes, mast cells, dendritic cells, neutrophils, and eosinophils. A variety of immunomodulatory characteristics, including the abilities to activate and differentiate immune cells, change the content and expression of inflammatory mediators, and regulate specific cellular functions and inflammation-related signaling pathways, are summarized and discussed in detail. This comprehensive review contributes to a better understanding of the role of AMPs in the regulation of the immune system and provides a reference for the use of AMPs as novel anti-inflammatory drugs for the treatment of various inflammatory diseases. MDPI 2023-09-04 /pmc/articles/PMC10535326/ /pubmed/37765247 http://dx.doi.org/10.3390/pharmaceutics15092278 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Hanxiao
Niu, Junhui
Wang, Xiaoli
Niu, Mingfu
Liao, Chengshui
The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances
title The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances
title_full The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances
title_fullStr The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances
title_full_unstemmed The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances
title_short The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances
title_sort contribution of antimicrobial peptides to immune cell function: a review of recent advances
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535326/
https://www.ncbi.nlm.nih.gov/pubmed/37765247
http://dx.doi.org/10.3390/pharmaceutics15092278
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