Cargando…

Can Pharmaceutical Excipients Threaten the Aquatic Environment? A Risk Assessment Based on the Microtox(®) Biotest

The ecotoxicological impact of pharmaceuticals has received considerable attention, primarily focusing on active pharmaceutical ingredients (APIs) while largely neglecting the potential hazards posed by pharmaceutical excipients. Therefore, we analyzed the ecotoxicity of 16 commonly used pharmaceuti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Turek, Marika, Różycka-Sokołowska, Ewa, Koprowski, Marek, Marciniak, Bernard, Bałczewski, Piotr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535389/ https://www.ncbi.nlm.nih.gov/pubmed/37764366 http://dx.doi.org/10.3390/molecules28186590

Ejemplares similares

Role of Hydrogen Bonds in Formation of Co-amorphous Valsartan/Nicotinamide Compositions of High Solubility and Durability with Anti-hypertension and Anti-COVID-19 Potential
por: Turek, Marika, et al.
Publicado: (2021)

The hetero-Friedel-Crafts-Bradsher Cyclizations with Formation of Ring Carbon-Heteroatom (P, S) Bonds, Leading to Organic Functional Materials
por: Skalik, Joanna, et al.
Publicado: (2020)

Organosulfur Materials with High Photo- and Photo-Oxidation Stability: 10-Anthryl Sulfoxides and Sulfones and Their Photophysical Properties Dependent on the Sulfur Oxidation State
por: Bałczewski, Piotr, et al.
Publicado: (2021)

Highly Substituted 10-RO-(hetero)acenes—Electric Properties of Vacuum-Deposited Molecular Films
por: Marciniak, Bernard, et al.
Publicado: (2023)

Synthesis of 1-indanones with a broad range of biological activity
por: Turek, Marika, et al.
Publicado: (2017)

Comprehensive Review on Synthesis, Properties, and Applications of Phosphorus (P(III), P(IV), P(V)) Substituted Acenes with More Than Two Fused Benzene Rings
por: Koprowski, Marek, et al.
Publicado: (2022)

O,S-Acetals in a New Modification of oxo-Friedel–Crafts–Bradsher Cyclization—Synthesis of Fluorescent (Hetero)acenes and Mechanistic Considerations
por: Owsianik, Krzysztof, et al.
Publicado: (2023)

Handbook of pharmaceutical excipients.
Publicado: (2003)

Possibilities of alternative generation II biotests at Artemia
por: Dvořák, Petr, et al.
Publicado: (2009)

Biotests in Cyanobacterial Toxicity Assessment—Efficient Enough or Not?
por: Davidović, Petar, et al.
Publicado: (2023)

Studies on the laccase-mediated decolorization, kinetic, and microtoxicity of some synthetic azo dyes
por: Forootanfar, Hamid, et al.
Publicado: (2016)

Pharmaceutical excipients and the information on drug labels
por: Balbani, Aracy Pereira Silveira, et al.
Publicado: (2015)

Biotests and Biosensors for Ecotoxicology of Metal Oxide Nanoparticles: A Minireview
por: Kahru, Anne, et al.
Publicado: (2008)

High-Throughput Phototactic Ecotoxicity Biotests with Nauplii of Artemia franciscana
por: Bai, Yutao, et al.
Publicado: (2022)

Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds
por: Jaszczak-Wilke, Ewa, et al.
Publicado: (2021)

COVID-19 pharmaceuticals in aquatic matrices: The threatening effects over cyanobacteria and microalgae
por: Marques, Raizza Zorman, et al.
Publicado: (2023)

The use of natural and synthetic phospholipids as pharmaceutical excipients*
por: van Hoogevest, Peter, et al.
Publicado: (2014)

Citric Acid: A Multifunctional Pharmaceutical Excipient
por: Lambros, Maria, et al.
Publicado: (2022)

Laccase-catalyzed decolorization and detoxification of Acid Blue 92: statistical optimization, microtoxicity, kinetics, and energetics
por: Rezaei, Shahla, et al.
Publicado: (2015)

Chitin and Chitosan as Direct Compression Excipients in Pharmaceutical Applications
por: Badwan, Adnan A., et al.
Publicado: (2015)

Pharmaceutical Excipients and Drug Metabolism: A Mini-Review
por: Patel, Rahul, et al.
Publicado: (2020)

Comparison of Prioritisation Schemes for Human Pharmaceuticals in the Aquatic Environment
por: Letsinger, Sarah, et al.
Publicado: (2018)

Comparison of Microtox and Xenoassay Light as a Near Real Time River Monitoring Assay for Heavy Metals
por: Halmi, M. I. E., et al.
Publicado: (2014)

Assessment of Individual and Combined Toxicities of Four Non-Essential Metals (As, Cd, Hg and Pb) in the Microtox Assay
por: Ishaque, Ali B., et al.
Publicado: (2006)

Biodegradation of Microtoxic Phenylpropanoids (Phenylpropanoic Acid and Ibuprofen) by Bacteria and the Relevance for Their Removal from Wastewater Treatment Plants
por: Wittich, Regina-Michaela, et al.
Publicado: (2023)

Modification of Biotesting-Based Fermented Dairy Product Design for Curd and Curd Products
por: Zobkova, Zinaida S., et al.
Publicado: (2022)

Significance of pharmaceutical excipients in prescribed medicines: a case report
por: Maharaj, Sandeep, et al.
Publicado: (2014)

Recently Investigated Natural Gums and Mucilages as Pharmaceutical Excipients: An Overview
por: Choudhary, Pritam Dinesh, et al.
Publicado: (2014)

Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
por: Kim, Hyeon, et al.
Publicado: (2018)

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications
por: Santos, Ana, et al.
Publicado: (2019)

Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates?
por: Kovacs, Tamas, et al.
Publicado: (2022)

Review of Applications of Cyclodextrins as Taste-Masking Excipients for Pharmaceutical Purposes
por: Adamkiewicz, Lena, et al.
Publicado: (2023)

Pharmaceutical Compounds in Aquatic Environments—Occurrence, Fate and Bioremediation Prospective
por: Fernandes, Joana P., et al.
Publicado: (2021)

Sex-Dependence in the Effect of Pharmaceutical Excipients: Polyoxyethylated Solubilising Excipients Increase Oral Drug Bioavailability in Male but Not Female Rats
por: Mai, Yang, et al.
Publicado: (2019)

Acute toxicity assessment of nine organic UV filters using a set of biotests
por: Marcin, Stec, et al.
Publicado: (2023)

A selective removal of the secondary hydroxy group from ortho-dithioacetal-substituted diarylmethanols
por: Czarnecka, Anna, et al.
Publicado: (2018)

Application of montmorillonite in bentonite as a pharmaceutical excipient in drug delivery systems
por: Park, Ju-Hwan, et al.
Publicado: (2016)

Mucilage of Coccinia grandis as an Efficient Natural Polymer-Based Pharmaceutical Excipient †
por: Ilango, Kumbakonam Balachandran, et al.
Publicado: (2022)

Toxicity of Graphene Shells, Graphene Oxide, and Graphene Oxide Paper Evaluated with Escherichia coli Biotests
por: Efremova, Ludmila V., et al.
Publicado: (2015)

Development of Composite, Reinforced, Highly Drug-Loaded Pharmaceutical Printlets Manufactured by Selective Laser Sintering—In Search of Relevant Excipients for Pharmaceutical 3D Printing
por: Kulinowski, Piotr, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u5d8he21g963853b5k19sja2m6