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Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review

Background and Objectives: Ejaculatory dysfunction (EjD) is a common male sexual disorder that includes premature ejaculation, delayed ejaculation, retrograde ejaculation, and anejaculation. Although psychological and pharmacological treatments are available, traditional, complementary, and alternat...

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Autores principales: Leisegang, Kristian, Opuwari, Chinyerum Sylvia, Moichela, Faith, Finelli, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535559/
https://www.ncbi.nlm.nih.gov/pubmed/37763726
http://dx.doi.org/10.3390/medicina59091607
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author Leisegang, Kristian
Opuwari, Chinyerum Sylvia
Moichela, Faith
Finelli, Renata
author_facet Leisegang, Kristian
Opuwari, Chinyerum Sylvia
Moichela, Faith
Finelli, Renata
author_sort Leisegang, Kristian
collection PubMed
description Background and Objectives: Ejaculatory dysfunction (EjD) is a common male sexual disorder that includes premature ejaculation, delayed ejaculation, retrograde ejaculation, and anejaculation. Although psychological and pharmacological treatments are available, traditional, complementary, and alternative medicine (TCAM) is reportedly used. However, the clinical evidence for TCAM in EjD remains unclear. Therefore, this study aims to systematically review human clinical trials investigating the use of TCAM to treat EjD. Materials and Methods: A systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted by searching Scopus and PubMed databases. Controlled clinical trials investigating a cohort of male patients diagnosed primarily with EjD and undergoing any TCAM intervention compared to any comparison group were included. Quality of the studies was assessed using the Cochrane Risk of Bias tool for randomized controlled trials. Results: Following article screening, 22 articles were included. Of these, 21 investigated TCAM in premature ejaculation, and only 1 investigated TCAM in retrograde ejaculation. Different TCAM categories included studies that investigated lifestyle, exercise and/or physical activities (n = 7); herbal medicine supplements (n = 5); topical herbal applications (n = 4); acupuncture or electroacupuncture (n = 3); vitamin, mineral and/or nutraceutical supplements (n = 1); hyaluronic acid penile injection (n = 1); and music therapy (n = 1). Only 31.8% (n = 7) of the included studies were found to have a low risk of bias. The available studies were widely heterogenous in the TCAM intervention investigated and comparison groups used. However, the included studies generally showed improved outcomes intra-group and when compared to placebo. Conclusions: Different TCAM interventions may have an important role particularly in the management of PE. However, more studies using standardized interventions are needed.
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spelling pubmed-105355592023-09-29 Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review Leisegang, Kristian Opuwari, Chinyerum Sylvia Moichela, Faith Finelli, Renata Medicina (Kaunas) Systematic Review Background and Objectives: Ejaculatory dysfunction (EjD) is a common male sexual disorder that includes premature ejaculation, delayed ejaculation, retrograde ejaculation, and anejaculation. Although psychological and pharmacological treatments are available, traditional, complementary, and alternative medicine (TCAM) is reportedly used. However, the clinical evidence for TCAM in EjD remains unclear. Therefore, this study aims to systematically review human clinical trials investigating the use of TCAM to treat EjD. Materials and Methods: A systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted by searching Scopus and PubMed databases. Controlled clinical trials investigating a cohort of male patients diagnosed primarily with EjD and undergoing any TCAM intervention compared to any comparison group were included. Quality of the studies was assessed using the Cochrane Risk of Bias tool for randomized controlled trials. Results: Following article screening, 22 articles were included. Of these, 21 investigated TCAM in premature ejaculation, and only 1 investigated TCAM in retrograde ejaculation. Different TCAM categories included studies that investigated lifestyle, exercise and/or physical activities (n = 7); herbal medicine supplements (n = 5); topical herbal applications (n = 4); acupuncture or electroacupuncture (n = 3); vitamin, mineral and/or nutraceutical supplements (n = 1); hyaluronic acid penile injection (n = 1); and music therapy (n = 1). Only 31.8% (n = 7) of the included studies were found to have a low risk of bias. The available studies were widely heterogenous in the TCAM intervention investigated and comparison groups used. However, the included studies generally showed improved outcomes intra-group and when compared to placebo. Conclusions: Different TCAM interventions may have an important role particularly in the management of PE. However, more studies using standardized interventions are needed. MDPI 2023-09-06 /pmc/articles/PMC10535559/ /pubmed/37763726 http://dx.doi.org/10.3390/medicina59091607 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Leisegang, Kristian
Opuwari, Chinyerum Sylvia
Moichela, Faith
Finelli, Renata
Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review
title Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review
title_full Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review
title_fullStr Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review
title_full_unstemmed Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review
title_short Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review
title_sort traditional, complementary and alternative medicines in the treatment of ejaculatory disorders: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535559/
https://www.ncbi.nlm.nih.gov/pubmed/37763726
http://dx.doi.org/10.3390/medicina59091607
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