Cargando…

Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels

Conventional biomaterial is frequently used in the biomedical sector for various therapies, imaging, treatment, and theranostic functions. However, their properties are fixed to meet certain applications. Smart materials respond in a controllable and reversible way, modifying some of their propertie...

Descripción completa

Detalles Bibliográficos
Autores principales: Ganeson, Keisheni, Tan Xue May, Cindy, Abdullah, Amirul Al Ashraf, Ramakrishna, Seeram, Vigneswari, Sevakumaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535616/
https://www.ncbi.nlm.nih.gov/pubmed/37765324
http://dx.doi.org/10.3390/pharmaceutics15092356
_version_ 1785112672285491200
author Ganeson, Keisheni
Tan Xue May, Cindy
Abdullah, Amirul Al Ashraf
Ramakrishna, Seeram
Vigneswari, Sevakumaran
author_facet Ganeson, Keisheni
Tan Xue May, Cindy
Abdullah, Amirul Al Ashraf
Ramakrishna, Seeram
Vigneswari, Sevakumaran
author_sort Ganeson, Keisheni
collection PubMed
description Conventional biomaterial is frequently used in the biomedical sector for various therapies, imaging, treatment, and theranostic functions. However, their properties are fixed to meet certain applications. Smart materials respond in a controllable and reversible way, modifying some of their properties because of external stimuli. However, protein-based smart materials allow modular protein domains with different functionalities and responsive behaviours to be easily combined. Wherein, these “smart” behaviours can be tuned by amino acid identity and sequence. This review aims to give an insight into the design of smart materials, mainly protein-based piezoelectric materials, shape-memory materials, and hydrogels, as well as highlight the current progress and challenges of protein-based smart materials in tissue engineering. These materials have demonstrated outstanding regeneration of neural, skin, cartilage, bone, and cardiac tissues with great stimuli-responsive properties, biocompatibility, biodegradability, and biofunctionality.
format Online
Article
Text
id pubmed-10535616
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105356162023-09-29 Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels Ganeson, Keisheni Tan Xue May, Cindy Abdullah, Amirul Al Ashraf Ramakrishna, Seeram Vigneswari, Sevakumaran Pharmaceutics Review Conventional biomaterial is frequently used in the biomedical sector for various therapies, imaging, treatment, and theranostic functions. However, their properties are fixed to meet certain applications. Smart materials respond in a controllable and reversible way, modifying some of their properties because of external stimuli. However, protein-based smart materials allow modular protein domains with different functionalities and responsive behaviours to be easily combined. Wherein, these “smart” behaviours can be tuned by amino acid identity and sequence. This review aims to give an insight into the design of smart materials, mainly protein-based piezoelectric materials, shape-memory materials, and hydrogels, as well as highlight the current progress and challenges of protein-based smart materials in tissue engineering. These materials have demonstrated outstanding regeneration of neural, skin, cartilage, bone, and cardiac tissues with great stimuli-responsive properties, biocompatibility, biodegradability, and biofunctionality. MDPI 2023-09-20 /pmc/articles/PMC10535616/ /pubmed/37765324 http://dx.doi.org/10.3390/pharmaceutics15092356 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ganeson, Keisheni
Tan Xue May, Cindy
Abdullah, Amirul Al Ashraf
Ramakrishna, Seeram
Vigneswari, Sevakumaran
Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels
title Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels
title_full Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels
title_fullStr Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels
title_full_unstemmed Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels
title_short Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels
title_sort advantages and prospective implications of smart materials in tissue engineering: piezoelectric, shape memory, and hydrogels
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535616/
https://www.ncbi.nlm.nih.gov/pubmed/37765324
http://dx.doi.org/10.3390/pharmaceutics15092356
work_keys_str_mv AT ganesonkeisheni advantagesandprospectiveimplicationsofsmartmaterialsintissueengineeringpiezoelectricshapememoryandhydrogels
AT tanxuemaycindy advantagesandprospectiveimplicationsofsmartmaterialsintissueengineeringpiezoelectricshapememoryandhydrogels
AT abdullahamirulalashraf advantagesandprospectiveimplicationsofsmartmaterialsintissueengineeringpiezoelectricshapememoryandhydrogels
AT ramakrishnaseeram advantagesandprospectiveimplicationsofsmartmaterialsintissueengineeringpiezoelectricshapememoryandhydrogels
AT vigneswarisevakumaran advantagesandprospectiveimplicationsofsmartmaterialsintissueengineeringpiezoelectricshapememoryandhydrogels