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Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels
Conventional biomaterial is frequently used in the biomedical sector for various therapies, imaging, treatment, and theranostic functions. However, their properties are fixed to meet certain applications. Smart materials respond in a controllable and reversible way, modifying some of their propertie...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535616/ https://www.ncbi.nlm.nih.gov/pubmed/37765324 http://dx.doi.org/10.3390/pharmaceutics15092356 |
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author | Ganeson, Keisheni Tan Xue May, Cindy Abdullah, Amirul Al Ashraf Ramakrishna, Seeram Vigneswari, Sevakumaran |
author_facet | Ganeson, Keisheni Tan Xue May, Cindy Abdullah, Amirul Al Ashraf Ramakrishna, Seeram Vigneswari, Sevakumaran |
author_sort | Ganeson, Keisheni |
collection | PubMed |
description | Conventional biomaterial is frequently used in the biomedical sector for various therapies, imaging, treatment, and theranostic functions. However, their properties are fixed to meet certain applications. Smart materials respond in a controllable and reversible way, modifying some of their properties because of external stimuli. However, protein-based smart materials allow modular protein domains with different functionalities and responsive behaviours to be easily combined. Wherein, these “smart” behaviours can be tuned by amino acid identity and sequence. This review aims to give an insight into the design of smart materials, mainly protein-based piezoelectric materials, shape-memory materials, and hydrogels, as well as highlight the current progress and challenges of protein-based smart materials in tissue engineering. These materials have demonstrated outstanding regeneration of neural, skin, cartilage, bone, and cardiac tissues with great stimuli-responsive properties, biocompatibility, biodegradability, and biofunctionality. |
format | Online Article Text |
id | pubmed-10535616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105356162023-09-29 Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels Ganeson, Keisheni Tan Xue May, Cindy Abdullah, Amirul Al Ashraf Ramakrishna, Seeram Vigneswari, Sevakumaran Pharmaceutics Review Conventional biomaterial is frequently used in the biomedical sector for various therapies, imaging, treatment, and theranostic functions. However, their properties are fixed to meet certain applications. Smart materials respond in a controllable and reversible way, modifying some of their properties because of external stimuli. However, protein-based smart materials allow modular protein domains with different functionalities and responsive behaviours to be easily combined. Wherein, these “smart” behaviours can be tuned by amino acid identity and sequence. This review aims to give an insight into the design of smart materials, mainly protein-based piezoelectric materials, shape-memory materials, and hydrogels, as well as highlight the current progress and challenges of protein-based smart materials in tissue engineering. These materials have demonstrated outstanding regeneration of neural, skin, cartilage, bone, and cardiac tissues with great stimuli-responsive properties, biocompatibility, biodegradability, and biofunctionality. MDPI 2023-09-20 /pmc/articles/PMC10535616/ /pubmed/37765324 http://dx.doi.org/10.3390/pharmaceutics15092356 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ganeson, Keisheni Tan Xue May, Cindy Abdullah, Amirul Al Ashraf Ramakrishna, Seeram Vigneswari, Sevakumaran Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels |
title | Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels |
title_full | Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels |
title_fullStr | Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels |
title_full_unstemmed | Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels |
title_short | Advantages and Prospective Implications of Smart Materials in Tissue Engineering: Piezoelectric, Shape Memory, and Hydrogels |
title_sort | advantages and prospective implications of smart materials in tissue engineering: piezoelectric, shape memory, and hydrogels |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535616/ https://www.ncbi.nlm.nih.gov/pubmed/37765324 http://dx.doi.org/10.3390/pharmaceutics15092356 |
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