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Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease

Diabetic kidney disease (DKD) is a global health issue that presents a complex pathogenesis and limited treatment options. To provide guidance for precise therapies, it is crucial to accurately identify the pathogenesis of DKD. Several studies have recognized that mitochondrial and endoplasmic retic...

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Autores principales: Liu, Yong, Qiao, Yingjin, Pan, Shaokang, Chen, Jingfang, Mao, Zihui, Ren, Kaidi, Yang, Yang, Feng, Qi, Liu, Dongwei, Liu, Zhangsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535705/
https://www.ncbi.nlm.nih.gov/pubmed/37781026
http://dx.doi.org/10.7150/ijbs.86608
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author Liu, Yong
Qiao, Yingjin
Pan, Shaokang
Chen, Jingfang
Mao, Zihui
Ren, Kaidi
Yang, Yang
Feng, Qi
Liu, Dongwei
Liu, Zhangsuo
author_facet Liu, Yong
Qiao, Yingjin
Pan, Shaokang
Chen, Jingfang
Mao, Zihui
Ren, Kaidi
Yang, Yang
Feng, Qi
Liu, Dongwei
Liu, Zhangsuo
author_sort Liu, Yong
collection PubMed
description Diabetic kidney disease (DKD) is a global health issue that presents a complex pathogenesis and limited treatment options. To provide guidance for precise therapies, it is crucial to accurately identify the pathogenesis of DKD. Several studies have recognized that mitochondrial and endoplasmic reticulum (ER) dysfunction are key drivers of the pathogenesis of DKD. The mitochondria-associated ER membrane (MAM) is a dynamic membrane contact site (MSC) that connects the ER and mitochondria and is essential in maintaining the normal function of the two organelles. MAM is involved in various cellular processes, including lipid synthesis and transport, calcium homeostasis, mitochondrial fusion and fission, and ER stress. Meanwhile, recent studies confirm that MAM plays a significant role in the pathogenesis of DKD by regulating glucose metabolism, lipid metabolism, inflammation, ER stress, mitochondrial fission and fusion, and autophagy. Herein, this review aims to provide a comprehensive summary of the physiological function of MAMs and their impact on the progression of DKD. Subsequently, we discuss the trend of pharmaceutical studies that target MAM resident proteins for treating DKD. Furthermore, we also explore the future development prospects of MAM in DKD research, thereby providing a new perspective for basic studies and clinical treatment of DKD.
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spelling pubmed-105357052023-09-29 Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease Liu, Yong Qiao, Yingjin Pan, Shaokang Chen, Jingfang Mao, Zihui Ren, Kaidi Yang, Yang Feng, Qi Liu, Dongwei Liu, Zhangsuo Int J Biol Sci Review Diabetic kidney disease (DKD) is a global health issue that presents a complex pathogenesis and limited treatment options. To provide guidance for precise therapies, it is crucial to accurately identify the pathogenesis of DKD. Several studies have recognized that mitochondrial and endoplasmic reticulum (ER) dysfunction are key drivers of the pathogenesis of DKD. The mitochondria-associated ER membrane (MAM) is a dynamic membrane contact site (MSC) that connects the ER and mitochondria and is essential in maintaining the normal function of the two organelles. MAM is involved in various cellular processes, including lipid synthesis and transport, calcium homeostasis, mitochondrial fusion and fission, and ER stress. Meanwhile, recent studies confirm that MAM plays a significant role in the pathogenesis of DKD by regulating glucose metabolism, lipid metabolism, inflammation, ER stress, mitochondrial fission and fusion, and autophagy. Herein, this review aims to provide a comprehensive summary of the physiological function of MAMs and their impact on the progression of DKD. Subsequently, we discuss the trend of pharmaceutical studies that target MAM resident proteins for treating DKD. Furthermore, we also explore the future development prospects of MAM in DKD research, thereby providing a new perspective for basic studies and clinical treatment of DKD. Ivyspring International Publisher 2023-08-21 /pmc/articles/PMC10535705/ /pubmed/37781026 http://dx.doi.org/10.7150/ijbs.86608 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Liu, Yong
Qiao, Yingjin
Pan, Shaokang
Chen, Jingfang
Mao, Zihui
Ren, Kaidi
Yang, Yang
Feng, Qi
Liu, Dongwei
Liu, Zhangsuo
Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease
title Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease
title_full Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease
title_fullStr Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease
title_full_unstemmed Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease
title_short Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease
title_sort broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (mam) dysfunction in diabetic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535705/
https://www.ncbi.nlm.nih.gov/pubmed/37781026
http://dx.doi.org/10.7150/ijbs.86608
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