Interferons—Implications in the Immune Response to Respiratory Viruses

Interferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that induce or antagonize IFN responses depending on...

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Detalles Bibliográficos
Autores principales: Bergeron, Harrison C., Hansen, Matthew R., Tripp, Ralph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535750/
https://www.ncbi.nlm.nih.gov/pubmed/37764023
http://dx.doi.org/10.3390/microorganisms11092179
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author Bergeron, Harrison C.
Hansen, Matthew R.
Tripp, Ralph A.
author_facet Bergeron, Harrison C.
Hansen, Matthew R.
Tripp, Ralph A.
author_sort Bergeron, Harrison C.
collection PubMed
description Interferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that induce or antagonize IFN responses depending on various factors. In this review, the role and function of type I, II, and III IFN responses to respiratory virus infections are considered. In addition, the role of the viral proteins in modifying anti-viral immunity is noted, as are the specific IFN responses that underly the correlates of immunity and protection from disease.
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spelling pubmed-105357502023-09-29 Interferons—Implications in the Immune Response to Respiratory Viruses Bergeron, Harrison C. Hansen, Matthew R. Tripp, Ralph A. Microorganisms Review Interferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that induce or antagonize IFN responses depending on various factors. In this review, the role and function of type I, II, and III IFN responses to respiratory virus infections are considered. In addition, the role of the viral proteins in modifying anti-viral immunity is noted, as are the specific IFN responses that underly the correlates of immunity and protection from disease. MDPI 2023-08-29 /pmc/articles/PMC10535750/ /pubmed/37764023 http://dx.doi.org/10.3390/microorganisms11092179 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bergeron, Harrison C.
Hansen, Matthew R.
Tripp, Ralph A.
Interferons—Implications in the Immune Response to Respiratory Viruses
title Interferons—Implications in the Immune Response to Respiratory Viruses
title_full Interferons—Implications in the Immune Response to Respiratory Viruses
title_fullStr Interferons—Implications in the Immune Response to Respiratory Viruses
title_full_unstemmed Interferons—Implications in the Immune Response to Respiratory Viruses
title_short Interferons—Implications in the Immune Response to Respiratory Viruses
title_sort interferons—implications in the immune response to respiratory viruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535750/
https://www.ncbi.nlm.nih.gov/pubmed/37764023
http://dx.doi.org/10.3390/microorganisms11092179
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