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Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital

Antimicrobial resistance (AMR) presents a growing threat to global healthcare. This descriptive epidemiological study investigates the prevalence and characteristics of Enterobacterales with AMR factors in a tertiary teaching hospital in Italy over the course of the year 2021. In 2021, the prevalenc...

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Autores principales: De Vita, Erica, De Angelis, Luigi, Arzilli, Guglielmo, Baglivo, Francesco, Barnini, Simona, Vecchione, Alessandra, Baggiani, Angelo, Rizzo, Caterina, Porretta, Andrea Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535761/
https://www.ncbi.nlm.nih.gov/pubmed/37764948
http://dx.doi.org/10.3390/pathogens12091140
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author De Vita, Erica
De Angelis, Luigi
Arzilli, Guglielmo
Baglivo, Francesco
Barnini, Simona
Vecchione, Alessandra
Baggiani, Angelo
Rizzo, Caterina
Porretta, Andrea Davide
author_facet De Vita, Erica
De Angelis, Luigi
Arzilli, Guglielmo
Baglivo, Francesco
Barnini, Simona
Vecchione, Alessandra
Baggiani, Angelo
Rizzo, Caterina
Porretta, Andrea Davide
author_sort De Vita, Erica
collection PubMed
description Antimicrobial resistance (AMR) presents a growing threat to global healthcare. This descriptive epidemiological study investigates the prevalence and characteristics of Enterobacterales with AMR factors in a tertiary teaching hospital in Italy over the course of the year 2021. In 2021, the prevalence of colonisation by Enterobacterales with AMR factors in patients was 1.08%. During the observation period, a total of 8834 rectal swabs were performed, with 1453 testing positive. A total of 5639 rectal swabs were performed according to a hospital procedure for the active screening of MDRO colonisation at the time of admission. Of these, 679 were positive for microorganisms under surveillance, and 74 patients were colonised with Enterobacterales, predominantly Klebsiella pneumoniae and Escherichia coli. Antibiotic resistance factors were observed in 61 of these 74 patients (82.43%) of these patients, with NDM and KPC being the most frequent resistance factors. A statistically significant trend in positive swabs was observed across different ward categories (surgery, ICUs, and medical wards). Regarding specific trends, the rate of positive admission screening in medical and surgical wards was higher than in ICU wards. The results highlight the ease with which Enterobacterales develops resistance across different ward categories. The findings underscore the need for adjusted screening protocols and tailored infection prevention strategies in various care settings.
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spelling pubmed-105357612023-09-29 Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital De Vita, Erica De Angelis, Luigi Arzilli, Guglielmo Baglivo, Francesco Barnini, Simona Vecchione, Alessandra Baggiani, Angelo Rizzo, Caterina Porretta, Andrea Davide Pathogens Article Antimicrobial resistance (AMR) presents a growing threat to global healthcare. This descriptive epidemiological study investigates the prevalence and characteristics of Enterobacterales with AMR factors in a tertiary teaching hospital in Italy over the course of the year 2021. In 2021, the prevalence of colonisation by Enterobacterales with AMR factors in patients was 1.08%. During the observation period, a total of 8834 rectal swabs were performed, with 1453 testing positive. A total of 5639 rectal swabs were performed according to a hospital procedure for the active screening of MDRO colonisation at the time of admission. Of these, 679 were positive for microorganisms under surveillance, and 74 patients were colonised with Enterobacterales, predominantly Klebsiella pneumoniae and Escherichia coli. Antibiotic resistance factors were observed in 61 of these 74 patients (82.43%) of these patients, with NDM and KPC being the most frequent resistance factors. A statistically significant trend in positive swabs was observed across different ward categories (surgery, ICUs, and medical wards). Regarding specific trends, the rate of positive admission screening in medical and surgical wards was higher than in ICU wards. The results highlight the ease with which Enterobacterales develops resistance across different ward categories. The findings underscore the need for adjusted screening protocols and tailored infection prevention strategies in various care settings. MDPI 2023-09-06 /pmc/articles/PMC10535761/ /pubmed/37764948 http://dx.doi.org/10.3390/pathogens12091140 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
De Vita, Erica
De Angelis, Luigi
Arzilli, Guglielmo
Baglivo, Francesco
Barnini, Simona
Vecchione, Alessandra
Baggiani, Angelo
Rizzo, Caterina
Porretta, Andrea Davide
Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital
title Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital
title_full Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital
title_fullStr Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital
title_full_unstemmed Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital
title_short Investigating Resistance to Carbapenems in Enterobacterales: A Descriptive Epidemiological Study of 2021 Screening in an Italian Teaching Hospital
title_sort investigating resistance to carbapenems in enterobacterales: a descriptive epidemiological study of 2021 screening in an italian teaching hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535761/
https://www.ncbi.nlm.nih.gov/pubmed/37764948
http://dx.doi.org/10.3390/pathogens12091140
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