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E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation

For productive infection and replication to occur, viruses must control cellular machinery and counteract restriction factors and antiviral proteins. Viruses can accomplish this, in part, via the regulation of cellular gene expression and post-transcriptional and post-translational control. Many vir...

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Autores principales: Oswald, Jessica, Constantine, Mathew, Adegbuyi, Adedolapo, Omorogbe, Esosa, Dellomo, Anna J., Ehrlich, Elana S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535929/
https://www.ncbi.nlm.nih.gov/pubmed/37766341
http://dx.doi.org/10.3390/v15091935
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author Oswald, Jessica
Constantine, Mathew
Adegbuyi, Adedolapo
Omorogbe, Esosa
Dellomo, Anna J.
Ehrlich, Elana S.
author_facet Oswald, Jessica
Constantine, Mathew
Adegbuyi, Adedolapo
Omorogbe, Esosa
Dellomo, Anna J.
Ehrlich, Elana S.
author_sort Oswald, Jessica
collection PubMed
description For productive infection and replication to occur, viruses must control cellular machinery and counteract restriction factors and antiviral proteins. Viruses can accomplish this, in part, via the regulation of cellular gene expression and post-transcriptional and post-translational control. Many viruses co-opt and counteract cellular processes via modulation of the host post-translational modification machinery and encoding or hijacking kinases, SUMO ligases, deubiquitinases, and ubiquitin ligases, in addition to other modifiers. In this review, we focus on three oncoviruses, Epstein–Barr virus (EBV), Kaposi’s sarcoma herpesvirus (KSHV), and human immunodeficiency virus (HIV) and their interactions with the ubiquitin–proteasome system via viral-encoded or cellular E3 ubiquitin ligase activity.
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spelling pubmed-105359292023-09-29 E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation Oswald, Jessica Constantine, Mathew Adegbuyi, Adedolapo Omorogbe, Esosa Dellomo, Anna J. Ehrlich, Elana S. Viruses Review For productive infection and replication to occur, viruses must control cellular machinery and counteract restriction factors and antiviral proteins. Viruses can accomplish this, in part, via the regulation of cellular gene expression and post-transcriptional and post-translational control. Many viruses co-opt and counteract cellular processes via modulation of the host post-translational modification machinery and encoding or hijacking kinases, SUMO ligases, deubiquitinases, and ubiquitin ligases, in addition to other modifiers. In this review, we focus on three oncoviruses, Epstein–Barr virus (EBV), Kaposi’s sarcoma herpesvirus (KSHV), and human immunodeficiency virus (HIV) and their interactions with the ubiquitin–proteasome system via viral-encoded or cellular E3 ubiquitin ligase activity. MDPI 2023-09-15 /pmc/articles/PMC10535929/ /pubmed/37766341 http://dx.doi.org/10.3390/v15091935 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oswald, Jessica
Constantine, Mathew
Adegbuyi, Adedolapo
Omorogbe, Esosa
Dellomo, Anna J.
Ehrlich, Elana S.
E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation
title E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation
title_full E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation
title_fullStr E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation
title_full_unstemmed E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation
title_short E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation
title_sort e3 ubiquitin ligases in gammaherpesviruses and hiv: a review of virus adaptation and exploitation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535929/
https://www.ncbi.nlm.nih.gov/pubmed/37766341
http://dx.doi.org/10.3390/v15091935
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