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A New Model of Salivary Pacemaker—A Proof of Concept and First Clinical Use
Background and Objectives: Saliva is of utmost importance for maintaining oral health. Management of saliva flow rate deficiency recently includes salivary neuro-electrostimulation. The aim of this paper is to present a new model of salivary pacemaker—the MICROSAL device (MD), an intelligent, miniat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535961/ https://www.ncbi.nlm.nih.gov/pubmed/37763766 http://dx.doi.org/10.3390/medicina59091647 |
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author | Funieru, Cristian Tudose, Dan Ștefan Dobrică, Bogdan Săndulescu, Mihai Popovici, Ion Alexandru Slușanschi, Emil Ioan Croitoru, Sorin Mihai Vrînceanu, Daniela Bănică, Bogdan Nicolescu, Mihnea Ioan |
author_facet | Funieru, Cristian Tudose, Dan Ștefan Dobrică, Bogdan Săndulescu, Mihai Popovici, Ion Alexandru Slușanschi, Emil Ioan Croitoru, Sorin Mihai Vrînceanu, Daniela Bănică, Bogdan Nicolescu, Mihnea Ioan |
author_sort | Funieru, Cristian |
collection | PubMed |
description | Background and Objectives: Saliva is of utmost importance for maintaining oral health. Management of saliva flow rate deficiency recently includes salivary neuro-electrostimulation. The aim of this paper is to present a new model of salivary pacemaker—the MICROSAL device (MD), an intelligent, miniaturized, and implant-supported oral device used for salivary stimulation. Materials and Methods: This report presents the development, calibration, and first clinical tests which involved the MD. The novel features of this device are the pH sensor and the fact that it communicates with the patient’s smartphone, where oral wetness and pH are graphically exposed. Saliva samples were taken before and after the MD was used on a 68-year-old patient suffering from post-irradiation xerostomia, and albumin and total protein were analyzed. Results: The device uses up to 3 V and time intervals of 2 s seconds for stimulation. The total volume of all saliva samples collected during the clinical trial was almost seven times higher after the device was used. Albumin decreased from a maximum of 0.15 g/dL to 0.04 g/dL, and total proteins from 0.65 g/dL to 0.21 g/dL, after salivary stimulation. Conclusions: The MD increased saliva secretion of the patient, and we are confident it will be a good solution for future management of salivary gland hypofunction. |
format | Online Article Text |
id | pubmed-10535961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105359612023-09-29 A New Model of Salivary Pacemaker—A Proof of Concept and First Clinical Use Funieru, Cristian Tudose, Dan Ștefan Dobrică, Bogdan Săndulescu, Mihai Popovici, Ion Alexandru Slușanschi, Emil Ioan Croitoru, Sorin Mihai Vrînceanu, Daniela Bănică, Bogdan Nicolescu, Mihnea Ioan Medicina (Kaunas) Article Background and Objectives: Saliva is of utmost importance for maintaining oral health. Management of saliva flow rate deficiency recently includes salivary neuro-electrostimulation. The aim of this paper is to present a new model of salivary pacemaker—the MICROSAL device (MD), an intelligent, miniaturized, and implant-supported oral device used for salivary stimulation. Materials and Methods: This report presents the development, calibration, and first clinical tests which involved the MD. The novel features of this device are the pH sensor and the fact that it communicates with the patient’s smartphone, where oral wetness and pH are graphically exposed. Saliva samples were taken before and after the MD was used on a 68-year-old patient suffering from post-irradiation xerostomia, and albumin and total protein were analyzed. Results: The device uses up to 3 V and time intervals of 2 s seconds for stimulation. The total volume of all saliva samples collected during the clinical trial was almost seven times higher after the device was used. Albumin decreased from a maximum of 0.15 g/dL to 0.04 g/dL, and total proteins from 0.65 g/dL to 0.21 g/dL, after salivary stimulation. Conclusions: The MD increased saliva secretion of the patient, and we are confident it will be a good solution for future management of salivary gland hypofunction. MDPI 2023-09-12 /pmc/articles/PMC10535961/ /pubmed/37763766 http://dx.doi.org/10.3390/medicina59091647 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Funieru, Cristian Tudose, Dan Ștefan Dobrică, Bogdan Săndulescu, Mihai Popovici, Ion Alexandru Slușanschi, Emil Ioan Croitoru, Sorin Mihai Vrînceanu, Daniela Bănică, Bogdan Nicolescu, Mihnea Ioan A New Model of Salivary Pacemaker—A Proof of Concept and First Clinical Use |
title | A New Model of Salivary Pacemaker—A Proof of Concept and First Clinical Use |
title_full | A New Model of Salivary Pacemaker—A Proof of Concept and First Clinical Use |
title_fullStr | A New Model of Salivary Pacemaker—A Proof of Concept and First Clinical Use |
title_full_unstemmed | A New Model of Salivary Pacemaker—A Proof of Concept and First Clinical Use |
title_short | A New Model of Salivary Pacemaker—A Proof of Concept and First Clinical Use |
title_sort | new model of salivary pacemaker—a proof of concept and first clinical use |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535961/ https://www.ncbi.nlm.nih.gov/pubmed/37763766 http://dx.doi.org/10.3390/medicina59091647 |
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