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Biomarkers and Functional Assays of Epithelial Barrier Disruption and Gastrointestinal Dysmotility in Critical Illness—A Narrative Review

Enteral nutrition in critically ill children has been associated with improved clinical outcomes. Gastrointestinal dysfunction often impedes the timely initiation and advancement of enteral nutrition and can contribute to immune dysregulation and systemic inflammation. Therefore, assessing gastroint...

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Detalles Bibliográficos
Autores principales: Martinez, Julianna, Rodriguez Hovnanian, K. Marco, Martinez, Enid E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535972/
https://www.ncbi.nlm.nih.gov/pubmed/37764835
http://dx.doi.org/10.3390/nu15184052
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author Martinez, Julianna
Rodriguez Hovnanian, K. Marco
Martinez, Enid E.
author_facet Martinez, Julianna
Rodriguez Hovnanian, K. Marco
Martinez, Enid E.
author_sort Martinez, Julianna
collection PubMed
description Enteral nutrition in critically ill children has been associated with improved clinical outcomes. Gastrointestinal dysfunction often impedes the timely initiation and advancement of enteral nutrition and can contribute to immune dysregulation and systemic inflammation. Therefore, assessing gastrointestinal function, at a cellular and functional level, is important to provide optimal enteral nutrition therapy and reduce the gastrointestinal tract’s contribution to the inflammatory cascade of critical illness. In this narrative review, we present an overview of biomarker and functional assays for gastrointestinal dysfunction, including epithelial barrier disruption and gastrointestinal dysmotility, that have been considered for critically ill patients.
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spelling pubmed-105359722023-09-29 Biomarkers and Functional Assays of Epithelial Barrier Disruption and Gastrointestinal Dysmotility in Critical Illness—A Narrative Review Martinez, Julianna Rodriguez Hovnanian, K. Marco Martinez, Enid E. Nutrients Review Enteral nutrition in critically ill children has been associated with improved clinical outcomes. Gastrointestinal dysfunction often impedes the timely initiation and advancement of enteral nutrition and can contribute to immune dysregulation and systemic inflammation. Therefore, assessing gastrointestinal function, at a cellular and functional level, is important to provide optimal enteral nutrition therapy and reduce the gastrointestinal tract’s contribution to the inflammatory cascade of critical illness. In this narrative review, we present an overview of biomarker and functional assays for gastrointestinal dysfunction, including epithelial barrier disruption and gastrointestinal dysmotility, that have been considered for critically ill patients. MDPI 2023-09-19 /pmc/articles/PMC10535972/ /pubmed/37764835 http://dx.doi.org/10.3390/nu15184052 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martinez, Julianna
Rodriguez Hovnanian, K. Marco
Martinez, Enid E.
Biomarkers and Functional Assays of Epithelial Barrier Disruption and Gastrointestinal Dysmotility in Critical Illness—A Narrative Review
title Biomarkers and Functional Assays of Epithelial Barrier Disruption and Gastrointestinal Dysmotility in Critical Illness—A Narrative Review
title_full Biomarkers and Functional Assays of Epithelial Barrier Disruption and Gastrointestinal Dysmotility in Critical Illness—A Narrative Review
title_fullStr Biomarkers and Functional Assays of Epithelial Barrier Disruption and Gastrointestinal Dysmotility in Critical Illness—A Narrative Review
title_full_unstemmed Biomarkers and Functional Assays of Epithelial Barrier Disruption and Gastrointestinal Dysmotility in Critical Illness—A Narrative Review
title_short Biomarkers and Functional Assays of Epithelial Barrier Disruption and Gastrointestinal Dysmotility in Critical Illness—A Narrative Review
title_sort biomarkers and functional assays of epithelial barrier disruption and gastrointestinal dysmotility in critical illness—a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535972/
https://www.ncbi.nlm.nih.gov/pubmed/37764835
http://dx.doi.org/10.3390/nu15184052
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