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Synthesis and Anti-Breast Cancer Potency of Mono- and Bis-(pyrazolyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine) Derivatives as EGFR/CDK-2 Target Inhibitors

[Image: see text] The target mono- and bis-(6-pyrazolyltriazolo-thiadiazine) derivatives 4a-c and 6a-d were synthesized using a straightforward protocol via reaction of 3-bromoacetylpyrazole 2 with 4-amino-s-triazole-3-thiols 3a-c and bis(4-amino-5-mercapto-s-triazol-3-yl)alkanes 5a-d, respectively....

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Detalles Bibliográficos
Autores principales:	Salem, Mostafa E., Mahrous, Esraa M., Ragab, Eman A., Nafie, Mohamed S., Dawood, Kamal M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536063/ https://www.ncbi.nlm.nih.gov/pubmed/37779952 http://dx.doi.org/10.1021/acsomega.3c05309

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