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Chemical, Pharmacological, and Theoretical Aspects of Some Transition Metal(II) Complexes Derived from Pyrrole Azine Schiff Base

[Image: see text] Some new transition metal complexes were prepared by reacting metal(II) salts with Schiff base azines, which were prepared via condensation of 5-(diethylamino) salicylaldehyde and hydrazine with pyrrole-2-carbaldehyde. Their structures were confirmed based on CHN, UV–visible, FT-IR...

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Autores principales: Arulmozhi, Sivan, Sasikumar, Gopalakrishnan, Subramani, Annadurai, Mohammed, Mustafa K. A., Ali, Syed J. Askar, Ponnusamy, Sasikumar, Jabir, Majid S., Elgorban, Abdallah M., Zhang, Wanli, Natarajan, Hema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536097/
https://www.ncbi.nlm.nih.gov/pubmed/37779929
http://dx.doi.org/10.1021/acsomega.3c02860
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author Arulmozhi, Sivan
Sasikumar, Gopalakrishnan
Subramani, Annadurai
Mohammed, Mustafa K. A.
Ali, Syed J. Askar
Ponnusamy, Sasikumar
Jabir, Majid S.
Elgorban, Abdallah M.
Zhang, Wanli
Natarajan, Hema
author_facet Arulmozhi, Sivan
Sasikumar, Gopalakrishnan
Subramani, Annadurai
Mohammed, Mustafa K. A.
Ali, Syed J. Askar
Ponnusamy, Sasikumar
Jabir, Majid S.
Elgorban, Abdallah M.
Zhang, Wanli
Natarajan, Hema
author_sort Arulmozhi, Sivan
collection PubMed
description [Image: see text] Some new transition metal complexes were prepared by reacting metal(II) salts with Schiff base azines, which were prepared via condensation of 5-(diethylamino) salicylaldehyde and hydrazine with pyrrole-2-carbaldehyde. Their structures were confirmed based on CHN, UV–visible, FT-IR, and EPR measurements. The complexes were also assessed for their antibacterial, antioxidant, and anticancer properties. Some of these chemicals were said to be extraordinarily effective in this respect. The antibacterial activities of the complexes in vitro demonstrated their potential, although the [Cu(L)(bpy] complex was suggested to exhibit moderate activity against pathogens compared to all other in this series. The cytotoxic activity of the prepared analogues showed better cell viability compared with standard cisplatin. Moreover, there is a good agreement between the experimental and theoretical findings from docking and theoretical investigations done using DFT at the B3LYP level.
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spelling pubmed-105360972023-09-29 Chemical, Pharmacological, and Theoretical Aspects of Some Transition Metal(II) Complexes Derived from Pyrrole Azine Schiff Base Arulmozhi, Sivan Sasikumar, Gopalakrishnan Subramani, Annadurai Mohammed, Mustafa K. A. Ali, Syed J. Askar Ponnusamy, Sasikumar Jabir, Majid S. Elgorban, Abdallah M. Zhang, Wanli Natarajan, Hema ACS Omega [Image: see text] Some new transition metal complexes were prepared by reacting metal(II) salts with Schiff base azines, which were prepared via condensation of 5-(diethylamino) salicylaldehyde and hydrazine with pyrrole-2-carbaldehyde. Their structures were confirmed based on CHN, UV–visible, FT-IR, and EPR measurements. The complexes were also assessed for their antibacterial, antioxidant, and anticancer properties. Some of these chemicals were said to be extraordinarily effective in this respect. The antibacterial activities of the complexes in vitro demonstrated their potential, although the [Cu(L)(bpy] complex was suggested to exhibit moderate activity against pathogens compared to all other in this series. The cytotoxic activity of the prepared analogues showed better cell viability compared with standard cisplatin. Moreover, there is a good agreement between the experimental and theoretical findings from docking and theoretical investigations done using DFT at the B3LYP level. American Chemical Society 2023-09-14 /pmc/articles/PMC10536097/ /pubmed/37779929 http://dx.doi.org/10.1021/acsomega.3c02860 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Arulmozhi, Sivan
Sasikumar, Gopalakrishnan
Subramani, Annadurai
Mohammed, Mustafa K. A.
Ali, Syed J. Askar
Ponnusamy, Sasikumar
Jabir, Majid S.
Elgorban, Abdallah M.
Zhang, Wanli
Natarajan, Hema
Chemical, Pharmacological, and Theoretical Aspects of Some Transition Metal(II) Complexes Derived from Pyrrole Azine Schiff Base
title Chemical, Pharmacological, and Theoretical Aspects of Some Transition Metal(II) Complexes Derived from Pyrrole Azine Schiff Base
title_full Chemical, Pharmacological, and Theoretical Aspects of Some Transition Metal(II) Complexes Derived from Pyrrole Azine Schiff Base
title_fullStr Chemical, Pharmacological, and Theoretical Aspects of Some Transition Metal(II) Complexes Derived from Pyrrole Azine Schiff Base
title_full_unstemmed Chemical, Pharmacological, and Theoretical Aspects of Some Transition Metal(II) Complexes Derived from Pyrrole Azine Schiff Base
title_short Chemical, Pharmacological, and Theoretical Aspects of Some Transition Metal(II) Complexes Derived from Pyrrole Azine Schiff Base
title_sort chemical, pharmacological, and theoretical aspects of some transition metal(ii) complexes derived from pyrrole azine schiff base
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536097/
https://www.ncbi.nlm.nih.gov/pubmed/37779929
http://dx.doi.org/10.1021/acsomega.3c02860
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