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Drug Discovery Based on Fluorine-Containing Glycomimetics
Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536126/ https://www.ncbi.nlm.nih.gov/pubmed/37764416 http://dx.doi.org/10.3390/molecules28186641 |
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author | Wei, Xingxing Wang, Pengyu Liu, Fen Ye, Xinshan Xiong, Decai |
author_facet | Wei, Xingxing Wang, Pengyu Liu, Fen Ye, Xinshan Xiong, Decai |
author_sort | Wei, Xingxing |
collection | PubMed |
description | Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance the metabolic stability, bioavailability, and protein-binding affinity of natural carbohydrates. In this review, the fluorination methods used to prepare the fluorinated carbohydrates, the effects of fluorination on the physical, chemical, and biological characteristics of natural sugars, and the biological activities of fluorinated sugars are presented. |
format | Online Article Text |
id | pubmed-10536126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105361262023-09-29 Drug Discovery Based on Fluorine-Containing Glycomimetics Wei, Xingxing Wang, Pengyu Liu, Fen Ye, Xinshan Xiong, Decai Molecules Review Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance the metabolic stability, bioavailability, and protein-binding affinity of natural carbohydrates. In this review, the fluorination methods used to prepare the fluorinated carbohydrates, the effects of fluorination on the physical, chemical, and biological characteristics of natural sugars, and the biological activities of fluorinated sugars are presented. MDPI 2023-09-15 /pmc/articles/PMC10536126/ /pubmed/37764416 http://dx.doi.org/10.3390/molecules28186641 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wei, Xingxing Wang, Pengyu Liu, Fen Ye, Xinshan Xiong, Decai Drug Discovery Based on Fluorine-Containing Glycomimetics |
title | Drug Discovery Based on Fluorine-Containing Glycomimetics |
title_full | Drug Discovery Based on Fluorine-Containing Glycomimetics |
title_fullStr | Drug Discovery Based on Fluorine-Containing Glycomimetics |
title_full_unstemmed | Drug Discovery Based on Fluorine-Containing Glycomimetics |
title_short | Drug Discovery Based on Fluorine-Containing Glycomimetics |
title_sort | drug discovery based on fluorine-containing glycomimetics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536126/ https://www.ncbi.nlm.nih.gov/pubmed/37764416 http://dx.doi.org/10.3390/molecules28186641 |
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