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Drug Discovery Based on Fluorine-Containing Glycomimetics

Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance t...

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Detalles Bibliográficos
Autores principales: Wei, Xingxing, Wang, Pengyu, Liu, Fen, Ye, Xinshan, Xiong, Decai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536126/
https://www.ncbi.nlm.nih.gov/pubmed/37764416
http://dx.doi.org/10.3390/molecules28186641
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author Wei, Xingxing
Wang, Pengyu
Liu, Fen
Ye, Xinshan
Xiong, Decai
author_facet Wei, Xingxing
Wang, Pengyu
Liu, Fen
Ye, Xinshan
Xiong, Decai
author_sort Wei, Xingxing
collection PubMed
description Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance the metabolic stability, bioavailability, and protein-binding affinity of natural carbohydrates. In this review, the fluorination methods used to prepare the fluorinated carbohydrates, the effects of fluorination on the physical, chemical, and biological characteristics of natural sugars, and the biological activities of fluorinated sugars are presented.
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spelling pubmed-105361262023-09-29 Drug Discovery Based on Fluorine-Containing Glycomimetics Wei, Xingxing Wang, Pengyu Liu, Fen Ye, Xinshan Xiong, Decai Molecules Review Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance the metabolic stability, bioavailability, and protein-binding affinity of natural carbohydrates. In this review, the fluorination methods used to prepare the fluorinated carbohydrates, the effects of fluorination on the physical, chemical, and biological characteristics of natural sugars, and the biological activities of fluorinated sugars are presented. MDPI 2023-09-15 /pmc/articles/PMC10536126/ /pubmed/37764416 http://dx.doi.org/10.3390/molecules28186641 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wei, Xingxing
Wang, Pengyu
Liu, Fen
Ye, Xinshan
Xiong, Decai
Drug Discovery Based on Fluorine-Containing Glycomimetics
title Drug Discovery Based on Fluorine-Containing Glycomimetics
title_full Drug Discovery Based on Fluorine-Containing Glycomimetics
title_fullStr Drug Discovery Based on Fluorine-Containing Glycomimetics
title_full_unstemmed Drug Discovery Based on Fluorine-Containing Glycomimetics
title_short Drug Discovery Based on Fluorine-Containing Glycomimetics
title_sort drug discovery based on fluorine-containing glycomimetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536126/
https://www.ncbi.nlm.nih.gov/pubmed/37764416
http://dx.doi.org/10.3390/molecules28186641
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