Cargando…
Impact of first and second/third wave of COVID-19 pandemic on post-acute cardiovascular outcomes in Lombardy
BACKGROUND: COVID-19 has been associated with a higher risk of post-acute complications. Our aim was to analyze and compare post-acute cardiovascular complications of COVID-19 survivors of the first and second/third pandemic waves in Lombardy, in both hospitalized and non-hospitalized COVID-19 patie...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536134/ https://www.ncbi.nlm.nih.gov/pubmed/37781303 http://dx.doi.org/10.3389/fcvm.2023.1244002 |
_version_ | 1785112794350223360 |
---|---|
author | Ojeda-Fernández, Luisa Baviera, Marta Foresta, Andreana Tettamanti, Mauro Zambon, Antonella Macaluso, Giulia Schena, Simone Leoni, Olivia Fortino, Ida Roncaglioni, Maria Carla Parati, Gianfranco |
author_facet | Ojeda-Fernández, Luisa Baviera, Marta Foresta, Andreana Tettamanti, Mauro Zambon, Antonella Macaluso, Giulia Schena, Simone Leoni, Olivia Fortino, Ida Roncaglioni, Maria Carla Parati, Gianfranco |
author_sort | Ojeda-Fernández, Luisa |
collection | PubMed |
description | BACKGROUND: COVID-19 has been associated with a higher risk of post-acute complications. Our aim was to analyze and compare post-acute cardiovascular complications of COVID-19 survivors of the first and second/third pandemic waves in Lombardy, in both hospitalized and non-hospitalized COVID-19 patients. METHODS AND RESULTS: We included adults aged ≥40 years infected during the first and second/third waves of COVID-19 pandemic. The follow-up initiated 30 days after COVID-19 diagnosis and continued up to 9 months. Hazard ratios (HRs) and 95% confidence intervals (CIs) of the post-acute cardiovascular outcomes were calculated against an inverse probability treatment weighted control group. Subgroup analysis were performed by age classes, sex, previous cardiovascular disease and stratified by COVID-19 hospitalization status to explore the impact of COVID-19 severity on outcomes. Compared to the control group, COVID-19 patients had an increased risk of hospitalization for any cardiovascular complications (HR 1st wave 1.53 95% CI: 1.38–1.69; HR 2nd/3rd wave 1.25 95% CI: 1.19–1.31) and for individual cardiovascular outcomes, although HRs were higher in COVID-19 group from the 1st pandemic wave. The results were confirmed in the subgroup analyses. Of note, the risk for any cardiovascular disease was also evident even among individuals who were not hospitalized during the acute phase of the infection. CONCLUSION: Our results provide evidence that COVID-19 is a risk factor for post-acute cardiovascular complications among different pandemic waves regardless of COVID-19 severity, age, sex and a history of cardiovascular diseases. Care strategies of people with COVID-19 should include cardiac monitoring. |
format | Online Article Text |
id | pubmed-10536134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105361342023-09-29 Impact of first and second/third wave of COVID-19 pandemic on post-acute cardiovascular outcomes in Lombardy Ojeda-Fernández, Luisa Baviera, Marta Foresta, Andreana Tettamanti, Mauro Zambon, Antonella Macaluso, Giulia Schena, Simone Leoni, Olivia Fortino, Ida Roncaglioni, Maria Carla Parati, Gianfranco Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: COVID-19 has been associated with a higher risk of post-acute complications. Our aim was to analyze and compare post-acute cardiovascular complications of COVID-19 survivors of the first and second/third pandemic waves in Lombardy, in both hospitalized and non-hospitalized COVID-19 patients. METHODS AND RESULTS: We included adults aged ≥40 years infected during the first and second/third waves of COVID-19 pandemic. The follow-up initiated 30 days after COVID-19 diagnosis and continued up to 9 months. Hazard ratios (HRs) and 95% confidence intervals (CIs) of the post-acute cardiovascular outcomes were calculated against an inverse probability treatment weighted control group. Subgroup analysis were performed by age classes, sex, previous cardiovascular disease and stratified by COVID-19 hospitalization status to explore the impact of COVID-19 severity on outcomes. Compared to the control group, COVID-19 patients had an increased risk of hospitalization for any cardiovascular complications (HR 1st wave 1.53 95% CI: 1.38–1.69; HR 2nd/3rd wave 1.25 95% CI: 1.19–1.31) and for individual cardiovascular outcomes, although HRs were higher in COVID-19 group from the 1st pandemic wave. The results were confirmed in the subgroup analyses. Of note, the risk for any cardiovascular disease was also evident even among individuals who were not hospitalized during the acute phase of the infection. CONCLUSION: Our results provide evidence that COVID-19 is a risk factor for post-acute cardiovascular complications among different pandemic waves regardless of COVID-19 severity, age, sex and a history of cardiovascular diseases. Care strategies of people with COVID-19 should include cardiac monitoring. Frontiers Media S.A. 2023-09-12 /pmc/articles/PMC10536134/ /pubmed/37781303 http://dx.doi.org/10.3389/fcvm.2023.1244002 Text en © 2023 Ojeda-Fernández, Baviera, Foresta, Tettamanti, Zambon, Macaluso, Schena, Leoni, Fortino, Roncaglioni and Parati. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Ojeda-Fernández, Luisa Baviera, Marta Foresta, Andreana Tettamanti, Mauro Zambon, Antonella Macaluso, Giulia Schena, Simone Leoni, Olivia Fortino, Ida Roncaglioni, Maria Carla Parati, Gianfranco Impact of first and second/third wave of COVID-19 pandemic on post-acute cardiovascular outcomes in Lombardy |
title | Impact of first and second/third wave of COVID-19 pandemic on post-acute cardiovascular outcomes in Lombardy |
title_full | Impact of first and second/third wave of COVID-19 pandemic on post-acute cardiovascular outcomes in Lombardy |
title_fullStr | Impact of first and second/third wave of COVID-19 pandemic on post-acute cardiovascular outcomes in Lombardy |
title_full_unstemmed | Impact of first and second/third wave of COVID-19 pandemic on post-acute cardiovascular outcomes in Lombardy |
title_short | Impact of first and second/third wave of COVID-19 pandemic on post-acute cardiovascular outcomes in Lombardy |
title_sort | impact of first and second/third wave of covid-19 pandemic on post-acute cardiovascular outcomes in lombardy |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536134/ https://www.ncbi.nlm.nih.gov/pubmed/37781303 http://dx.doi.org/10.3389/fcvm.2023.1244002 |
work_keys_str_mv | AT ojedafernandezluisa impactoffirstandsecondthirdwaveofcovid19pandemiconpostacutecardiovascularoutcomesinlombardy AT bavieramarta impactoffirstandsecondthirdwaveofcovid19pandemiconpostacutecardiovascularoutcomesinlombardy AT forestaandreana impactoffirstandsecondthirdwaveofcovid19pandemiconpostacutecardiovascularoutcomesinlombardy AT tettamantimauro impactoffirstandsecondthirdwaveofcovid19pandemiconpostacutecardiovascularoutcomesinlombardy AT zambonantonella impactoffirstandsecondthirdwaveofcovid19pandemiconpostacutecardiovascularoutcomesinlombardy AT macalusogiulia impactoffirstandsecondthirdwaveofcovid19pandemiconpostacutecardiovascularoutcomesinlombardy AT schenasimone impactoffirstandsecondthirdwaveofcovid19pandemiconpostacutecardiovascularoutcomesinlombardy AT leoniolivia impactoffirstandsecondthirdwaveofcovid19pandemiconpostacutecardiovascularoutcomesinlombardy AT fortinoida impactoffirstandsecondthirdwaveofcovid19pandemiconpostacutecardiovascularoutcomesinlombardy AT roncaglionimariacarla impactoffirstandsecondthirdwaveofcovid19pandemiconpostacutecardiovascularoutcomesinlombardy AT paratigianfranco impactoffirstandsecondthirdwaveofcovid19pandemiconpostacutecardiovascularoutcomesinlombardy |