Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world, and alpha-synuclein (α-syn) abnormal aggregate and mitochondrial dysfunction play a crucial role in its pathological development. Recent studies have revealed that proteins can form condensates through liquid–...

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Detalles Bibliográficos
Autores principales: Hou, Kaiying, Liu, Tingting, Li, Jingwen, Xian, Meiyan, Sun, Lin, Wei, Jianshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536155/
https://www.ncbi.nlm.nih.gov/pubmed/37781241
http://dx.doi.org/10.3389/fnins.2023.1250532
Descripción
Sumario:Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world, and alpha-synuclein (α-syn) abnormal aggregate and mitochondrial dysfunction play a crucial role in its pathological development. Recent studies have revealed that proteins can form condensates through liquid–liquid phase separation (LLPS), and LLPS has been found to be widely present in α-syn aberrant aggregate and mitophagy-related protein physiological processes. This review summarizes the occurrence of α-syn LLPS and its influencing factors, introduces the production and transformation of the related protein LLPS during PINK1-Parkin-mediated mitophagy, hoping to provide new ideas and methods for the study of PD pathology.

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