Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world, and alpha-synuclein (α-syn) abnormal aggregate and mitochondrial dysfunction play a crucial role in its pathological development. Recent studies have revealed that proteins can form condensates through liquid–...

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Autores principales: Hou, Kaiying, Liu, Tingting, Li, Jingwen, Xian, Meiyan, Sun, Lin, Wei, Jianshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536155/
https://www.ncbi.nlm.nih.gov/pubmed/37781241
http://dx.doi.org/10.3389/fnins.2023.1250532
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author Hou, Kaiying
Liu, Tingting
Li, Jingwen
Xian, Meiyan
Sun, Lin
Wei, Jianshe
author_facet Hou, Kaiying
Liu, Tingting
Li, Jingwen
Xian, Meiyan
Sun, Lin
Wei, Jianshe
author_sort Hou, Kaiying
collection PubMed
description Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world, and alpha-synuclein (α-syn) abnormal aggregate and mitochondrial dysfunction play a crucial role in its pathological development. Recent studies have revealed that proteins can form condensates through liquid–liquid phase separation (LLPS), and LLPS has been found to be widely present in α-syn aberrant aggregate and mitophagy-related protein physiological processes. This review summarizes the occurrence of α-syn LLPS and its influencing factors, introduces the production and transformation of the related protein LLPS during PINK1-Parkin-mediated mitophagy, hoping to provide new ideas and methods for the study of PD pathology.
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spelling pubmed-105361552023-09-29 Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease Hou, Kaiying Liu, Tingting Li, Jingwen Xian, Meiyan Sun, Lin Wei, Jianshe Front Neurosci Neuroscience Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world, and alpha-synuclein (α-syn) abnormal aggregate and mitochondrial dysfunction play a crucial role in its pathological development. Recent studies have revealed that proteins can form condensates through liquid–liquid phase separation (LLPS), and LLPS has been found to be widely present in α-syn aberrant aggregate and mitophagy-related protein physiological processes. This review summarizes the occurrence of α-syn LLPS and its influencing factors, introduces the production and transformation of the related protein LLPS during PINK1-Parkin-mediated mitophagy, hoping to provide new ideas and methods for the study of PD pathology. Frontiers Media S.A. 2023-09-14 /pmc/articles/PMC10536155/ /pubmed/37781241 http://dx.doi.org/10.3389/fnins.2023.1250532 Text en Copyright © 2023 Hou, Liu, Li, Xian, Sun and Wei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hou, Kaiying
Liu, Tingting
Li, Jingwen
Xian, Meiyan
Sun, Lin
Wei, Jianshe
Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease
title Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease
title_full Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease
title_fullStr Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease
title_full_unstemmed Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease
title_short Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease
title_sort liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in parkinson’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536155/
https://www.ncbi.nlm.nih.gov/pubmed/37781241
http://dx.doi.org/10.3389/fnins.2023.1250532
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