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Wearable Device for Cumulative Chlorobenzene Detection and Accessible Mitigation Strategies
Chronic exposure to low concentrations of volatile organic compounds (VOCs), such as chlorobenzene, is not being monitored in industrializing countries, although VOC exposure is associated with carcinogenic, organ-toxic, and endocrine-disrupting effects. Current VOC-sensing technologies are inaccess...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536231/ https://www.ncbi.nlm.nih.gov/pubmed/37765961 http://dx.doi.org/10.3390/s23187904 |
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author | Mago, Aryan Yang, Yeon-Suk Shim, Jae-Hyuck John, Aijaz Ahmad |
author_facet | Mago, Aryan Yang, Yeon-Suk Shim, Jae-Hyuck John, Aijaz Ahmad |
author_sort | Mago, Aryan |
collection | PubMed |
description | Chronic exposure to low concentrations of volatile organic compounds (VOCs), such as chlorobenzene, is not being monitored in industrializing countries, although VOC exposure is associated with carcinogenic, organ-toxic, and endocrine-disrupting effects. Current VOC-sensing technologies are inaccessible due to high cost, size, and maintenance or are ineffective due to poor sensitivity or reliability. In particular, marginalized individuals face barriers to traditional prescription VOC treatments due to cost, lack of transportation, and limited access to physicians; thus, alternative treatments are needed. Here, we created a novel cumulative wearable color-changing VOC sensor with a paper-based polydiacetylene sensor array for chlorobenzene. With a single smartphone picture, the sensor displays 14 days of logged chlorobenzene exposure data, interpreted by machine-learning (ML) techniques, including principal component analysis. Further, we explored the efficacy of affordable and accessible treatment options to mitigate a VOC’s toxic effects. Vitamin D and sulforaphane are naturally found in cruciferous vegetables, like broccoli, and can be used to treat chlorobenzene-mediated bone degradation. Our platform combines these components into a smartphone app that photographs the sensor’s colorimetric data, analyzes the data via ML techniques, and offers accessible treatments based on exposure data. |
format | Online Article Text |
id | pubmed-10536231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105362312023-09-29 Wearable Device for Cumulative Chlorobenzene Detection and Accessible Mitigation Strategies Mago, Aryan Yang, Yeon-Suk Shim, Jae-Hyuck John, Aijaz Ahmad Sensors (Basel) Article Chronic exposure to low concentrations of volatile organic compounds (VOCs), such as chlorobenzene, is not being monitored in industrializing countries, although VOC exposure is associated with carcinogenic, organ-toxic, and endocrine-disrupting effects. Current VOC-sensing technologies are inaccessible due to high cost, size, and maintenance or are ineffective due to poor sensitivity or reliability. In particular, marginalized individuals face barriers to traditional prescription VOC treatments due to cost, lack of transportation, and limited access to physicians; thus, alternative treatments are needed. Here, we created a novel cumulative wearable color-changing VOC sensor with a paper-based polydiacetylene sensor array for chlorobenzene. With a single smartphone picture, the sensor displays 14 days of logged chlorobenzene exposure data, interpreted by machine-learning (ML) techniques, including principal component analysis. Further, we explored the efficacy of affordable and accessible treatment options to mitigate a VOC’s toxic effects. Vitamin D and sulforaphane are naturally found in cruciferous vegetables, like broccoli, and can be used to treat chlorobenzene-mediated bone degradation. Our platform combines these components into a smartphone app that photographs the sensor’s colorimetric data, analyzes the data via ML techniques, and offers accessible treatments based on exposure data. MDPI 2023-09-15 /pmc/articles/PMC10536231/ /pubmed/37765961 http://dx.doi.org/10.3390/s23187904 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mago, Aryan Yang, Yeon-Suk Shim, Jae-Hyuck John, Aijaz Ahmad Wearable Device for Cumulative Chlorobenzene Detection and Accessible Mitigation Strategies |
title | Wearable Device for Cumulative Chlorobenzene Detection and Accessible Mitigation Strategies |
title_full | Wearable Device for Cumulative Chlorobenzene Detection and Accessible Mitigation Strategies |
title_fullStr | Wearable Device for Cumulative Chlorobenzene Detection and Accessible Mitigation Strategies |
title_full_unstemmed | Wearable Device for Cumulative Chlorobenzene Detection and Accessible Mitigation Strategies |
title_short | Wearable Device for Cumulative Chlorobenzene Detection and Accessible Mitigation Strategies |
title_sort | wearable device for cumulative chlorobenzene detection and accessible mitigation strategies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536231/ https://www.ncbi.nlm.nih.gov/pubmed/37765961 http://dx.doi.org/10.3390/s23187904 |
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